Cytoplasmic acidification is not an effector mechanism of VP16 or DEX-induced apoptosis in CEM T leukaemia cells

The role of intracellular acidification in the execution phase of apoptosis is not well understood. Here we examine the effect of Bcl-2 over-expression on intracellular acidification occurring during apoptosis. We found, that in CEM cells, neither DEX nor VP16-induced apoptosis lead to a significant...

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Veröffentlicht in:	Journal of cell science 1999-06, Vol.112 ( Pt 11) (11), p.1755-1760
Hauptverfasser:	Benson, R S, Dive, C, Watson, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antineoplastic Agents, Hormonal - metabolism Antineoplastic Agents, Hormonal - pharmacology Apoptosis Cytoplasm - physiology Dexamethasone - metabolism Dexamethasone - pharmacology Etoposide - metabolism Etoposide - pharmacology Humans Hydrogen-Ion Concentration Nucleic Acid Synthesis Inhibitors - metabolism Nucleic Acid Synthesis Inhibitors - pharmacology Proto-Oncogene Proteins c-bcl-2 - metabolism Tumor Cells, Cultured
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