Anaplastic carcinoma of the thyroid
Background: Anaplastic thyroid carcinoma, albeit rare, is one of the most aggressive human tumors, with a dismal prognosis. Methods: Twenty-eight patients with anaplastic thyroid carcinoma were identified during the past 30 years to evaluate its clinicopathologic features and to document our experie...
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| Veröffentlicht in: | The American journal of surgery 1999-04, Vol.177 (4), p.337-339 |
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| creator | Lo, Chung-yau Lam, King-yin Wan, Koon-yat |
| description | Background: Anaplastic thyroid carcinoma, albeit rare, is one of the most aggressive human tumors, with a dismal prognosis.
Methods: Twenty-eight patients with anaplastic thyroid carcinoma were identified during the past 30 years to evaluate its clinicopathologic features and to document our experience in management. Potential risk factors for survival time were analyzed.
Results: The usual presentation was that of a rapidly enlarging neck mass. Distant metastases were present in 50% of patients on presentation. Palliative resection was performed in 16 patients. The median survival was 38 days, and the 2-year survival rate was 4%. Among factors analyzed, patients selected for surgical resection, absence of distant metastases at presentation, young age, and tumor size |
| doi_str_mv | 10.1016/S0002-9610(99)00052-5 |
| format | Article |
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Methods: Twenty-eight patients with anaplastic thyroid carcinoma were identified during the past 30 years to evaluate its clinicopathologic features and to document our experience in management. Potential risk factors for survival time were analyzed.
Results: The usual presentation was that of a rapidly enlarging neck mass. Distant metastases were present in 50% of patients on presentation. Palliative resection was performed in 16 patients. The median survival was 38 days, and the 2-year survival rate was 4%. Among factors analyzed, patients selected for surgical resection, absence of distant metastases at presentation, young age, and tumor size <6 cm were associated with an increased survival time. Concomitant well-differentiated thyroid carcinoma and p53 overexpression were present in 12 of the 22 and 13 of the 19 specimens, respectively.
Conclusions: Patients with anaplastic carcinoma of thyroid have a dismal prognosis heralding imminent death. Surgical ablation followed by adjuvant therapy can provide palliation for selected patients only.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(99)00052-5</identifier><identifier>PMID: 10326855</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Ablation ; Aged ; Airway management ; Autopsies ; Biological and medical sciences ; Biopsy ; Carcinoma - epidemiology ; Carcinoma - pathology ; Carcinoma - surgery ; Chemotherapy ; Diagnosis, Differential ; Endocrinopathies ; Female ; Histology ; Humans ; Intubation ; Male ; Malignant tumors ; Medical prognosis ; Medical sciences ; Metastases ; Metastasis ; Middle Aged ; Mortality ; Neoplasm Staging ; Ostomy ; Palliation ; Patients ; Prognosis ; Radiation therapy ; Retrospective Studies ; Risk Factors ; Surgery ; Surgical Procedures, Operative ; Survival ; Survival Analysis ; Thyroid ; Thyroid cancer ; Thyroid carcinoma ; Thyroid diseases ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroid. Thyroid axis (diseases) ; Tracheotomy ; Tumors</subject><ispartof>The American journal of surgery, 1999-04, Vol.177 (4), p.337-339</ispartof><rights>1999 Excerpta Medica Inc.</rights><rights>1999 INIST-CNRS</rights><rights>1999. Excerpta Medica Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-c88ce0cf7a8f42dc7dac6db428575de8cc5f0deef9efdc6f5fbe1ff50e3d24ca3</citedby><cites>FETCH-LOGICAL-c470t-c88ce0cf7a8f42dc7dac6db428575de8cc5f0deef9efdc6f5fbe1ff50e3d24ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2847440777?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1781689$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10326855$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lo, Chung-yau</creatorcontrib><creatorcontrib>Lam, King-yin</creatorcontrib><creatorcontrib>Wan, Koon-yat</creatorcontrib><title>Anaplastic carcinoma of the thyroid</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Background: Anaplastic thyroid carcinoma, albeit rare, is one of the most aggressive human tumors, with a dismal prognosis.
Methods: Twenty-eight patients with anaplastic thyroid carcinoma were identified during the past 30 years to evaluate its clinicopathologic features and to document our experience in management. Potential risk factors for survival time were analyzed.
Results: The usual presentation was that of a rapidly enlarging neck mass. Distant metastases were present in 50% of patients on presentation. Palliative resection was performed in 16 patients. The median survival was 38 days, and the 2-year survival rate was 4%. Among factors analyzed, patients selected for surgical resection, absence of distant metastases at presentation, young age, and tumor size <6 cm were associated with an increased survival time. Concomitant well-differentiated thyroid carcinoma and p53 overexpression were present in 12 of the 22 and 13 of the 19 specimens, respectively.
Conclusions: Patients with anaplastic carcinoma of thyroid have a dismal prognosis heralding imminent death. Surgical ablation followed by adjuvant therapy can provide palliation for selected patients only.</description><subject>Ablation</subject><subject>Aged</subject><subject>Airway management</subject><subject>Autopsies</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Carcinoma - epidemiology</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Chemotherapy</subject><subject>Diagnosis, Differential</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Histology</subject><subject>Humans</subject><subject>Intubation</subject><subject>Male</subject><subject>Malignant tumors</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasm Staging</subject><subject>Ostomy</subject><subject>Palliation</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical Procedures, Operative</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid carcinoma</subject><subject>Thyroid diseases</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroid. Thyroid axis (diseases)</subject><subject>Tracheotomy</subject><subject>Tumors</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkE1LxDAQhoMouq7-BGVhRfRQTdqmSU4ii1-w4EE9h-xkgpFuuyat4L83-4GKFw_D8MIzL8NDyBGjF4yy6vKJUppnqmL0TKnzFHie8S0yYFKojElZbJPBN7JH9mN8S5Gxstgle4wWeSU5H5DxdWMWtYmdhxGYAL5p52bUulH3imk-Q-vtAdlxpo54uNlD8nJ78zy5z6aPdw-T62kGpaBdBlICUnDCSFfmFoQ1UNlZmUsuuEUJwB21iE6hs1A57mbInOMUC5uXYIohOV33LkL73mPs9NxHwLo2DbZ91JUSvBAVT-D4D_jW9qFJv-lclqIsqRAiUXxNQWhjDOj0Ivi5CZ-aUb10qFcO9VKQVkqvHOpl-_GmvZ_N0f66WktLwMkGMBFM7YJpwMcfTkhWSZWwqzWGydmHx6AjeGwArQ8Inbat_-eTL805jSU</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Lo, Chung-yau</creator><creator>Lam, King-yin</creator><creator>Wan, Koon-yat</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Anaplastic carcinoma of the thyroid</title><author>Lo, Chung-yau ; Lam, King-yin ; Wan, Koon-yat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-c88ce0cf7a8f42dc7dac6db428575de8cc5f0deef9efdc6f5fbe1ff50e3d24ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Ablation</topic><topic>Aged</topic><topic>Airway management</topic><topic>Autopsies</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Carcinoma - epidemiology</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Chemotherapy</topic><topic>Diagnosis, Differential</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Histology</topic><topic>Humans</topic><topic>Intubation</topic><topic>Male</topic><topic>Malignant tumors</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasm Staging</topic><topic>Ostomy</topic><topic>Palliation</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgical Procedures, Operative</topic><topic>Survival</topic><topic>Survival Analysis</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid carcinoma</topic><topic>Thyroid diseases</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroid. Thyroid axis (diseases)</topic><topic>Tracheotomy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lo, Chung-yau</creatorcontrib><creatorcontrib>Lam, King-yin</creatorcontrib><creatorcontrib>Wan, Koon-yat</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lo, Chung-yau</au><au>Lam, King-yin</au><au>Wan, Koon-yat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaplastic carcinoma of the thyroid</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>177</volume><issue>4</issue><spage>337</spage><epage>339</epage><pages>337-339</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>Background: Anaplastic thyroid carcinoma, albeit rare, is one of the most aggressive human tumors, with a dismal prognosis.
Methods: Twenty-eight patients with anaplastic thyroid carcinoma were identified during the past 30 years to evaluate its clinicopathologic features and to document our experience in management. Potential risk factors for survival time were analyzed.
Results: The usual presentation was that of a rapidly enlarging neck mass. Distant metastases were present in 50% of patients on presentation. Palliative resection was performed in 16 patients. The median survival was 38 days, and the 2-year survival rate was 4%. Among factors analyzed, patients selected for surgical resection, absence of distant metastases at presentation, young age, and tumor size <6 cm were associated with an increased survival time. Concomitant well-differentiated thyroid carcinoma and p53 overexpression were present in 12 of the 22 and 13 of the 19 specimens, respectively.
Conclusions: Patients with anaplastic carcinoma of thyroid have a dismal prognosis heralding imminent death. Surgical ablation followed by adjuvant therapy can provide palliation for selected patients only.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10326855</pmid><doi>10.1016/S0002-9610(99)00052-5</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1999-04, Vol.177 (4), p.337-339 |
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| subjects | Ablation Aged Airway management Autopsies Biological and medical sciences Biopsy Carcinoma - epidemiology Carcinoma - pathology Carcinoma - surgery Chemotherapy Diagnosis, Differential Endocrinopathies Female Histology Humans Intubation Male Malignant tumors Medical prognosis Medical sciences Metastases Metastasis Middle Aged Mortality Neoplasm Staging Ostomy Palliation Patients Prognosis Radiation therapy Retrospective Studies Risk Factors Surgery Surgical Procedures, Operative Survival Survival Analysis Thyroid Thyroid cancer Thyroid carcinoma Thyroid diseases Thyroid Neoplasms - epidemiology Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroid. Thyroid axis (diseases) Tracheotomy Tumors |
| title | Anaplastic carcinoma of the thyroid |
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