The WD repeat: a common architecture for diverse functions
Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption...
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| Veröffentlicht in: | Trends in Biochemical Sciences 1999-05, Vol.24 (5), p.181-185 |
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| container_title | Trends in Biochemical Sciences |
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| creator | Smith, Temple F Gaitatzes, Chrysanthe Saxena, Kumkum Neer, Eva J |
| description | Our knowledge of the large family of proteins that contain the WD repeat continues to accumulate. The WD-repeat proteins are found in all eukaryotes and are implicated in a wide variety of crucial functions. The solution of the three-dimensional structure of one WD-repeat protein and the assumption that the structure will be common to all members of this family has allowed subfamilies of WD-repeat proteins to be defined on the basis of probable surface similarity. Proteins that have very similar surfaces are likely to have common binding partners and similar functions. |
| doi_str_mv | 10.1016/S0968-0004(99)01384-5 |
| format | Article |
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| ispartof | Trends in Biochemical Sciences, 1999-05, Vol.24 (5), p.181-185 |
| issn | 0968-0004 1362-4326 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Arabidopsis - chemistry Caenorhabditis elegans - chemistry Fungal Proteins - chemistry G. Protein GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism Protein Conformation Proteins - chemistry Proteins - metabolism Repetitive Sequences, Amino Acid WD repeat WD repeat proteins β propeller |
| title | The WD repeat: a common architecture for diverse functions |
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