Palmitoyl-protein thioesterase, an enzyme implicated in neurodegeneration, is localized in neurons and is developmentally regulated in rat brain

Palmitoyl-protein thioesterase (PPT) is an enzyme involved in cleavage of palmitate residues from acylated proteins. Mutations in PPT gene cause a severe neurodegenerative disorder, infantile neuronal ceroid-lipofuscinosis (INCL), characterized by loss of cortical neurons. In order to clarify the ro...

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Veröffentlicht in:	Neuroscience letters 1999-04, Vol.265 (1), p.53-56
Hauptverfasser:	Suopanki, Jaana, Tyynelä, Jaana, Baumann, Marc, Haltia, Matti
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Brain development Development. Senescence. Regeneration. Transplantation Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - physiology Immunohistochemistry Infantile neuronal ceroid-lipofuscinosis Nerve Degeneration Neurons - chemistry Palmitoyl-protein thioesterase Rats Reverse Transcriptase Polymerase Chain Reaction RT-PCR, protein expression Thiolester Hydrolases - analysis Thiolester Hydrolases - genetics Vertebrates: nervous system and sense organs
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