Single-domain antibodies as building blocks for novel therapeutics

Antibodies are large and complex molecules, with two identical parts that bind independently of each other onto the antigen and the third part of the molecule that dictates the effector function(s). To improve the therapeutic value of antibodies, protein-engineering endeavors reduced the size of the...

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Veröffentlicht in:	Current opinion in pharmacology 2008-10, Vol.8 (5), p.600-608
Hauptverfasser:	Saerens, Dirk, Ghassabeh, Gholamreza Hassanzadeh, Muyldermans, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - chemistry Antibodies - genetics Antibodies - therapeutic use Antibodies, Blocking - chemistry Antibodies, Blocking - genetics Antibodies, Blocking - therapeutic use Humans Internal Medicine Medical Education Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - therapeutic use
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