Perturbation of RET signaling in the embryonic kidney

We have used a RET‐Ig fusion protein to disrupt signaling in the rat embryonic kidney development pathway. Treatment of embryonic kidney organ cultures with RET‐Ig results in a decrease in branching of the ureteric bud and a down regulation in expression of the Wnt‐11, Wnt‐4, and ld genes. These dat...

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Veröffentlicht in:	Developmental genetics 1999, Vol.24 (3-4), p.263-272
Hauptverfasser:	Ehrenfels, Christian W., Carmillo, Paul J., Orozco, Olivia, Cate, Richard L., Sanicola, Michele
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins - genetics DNA Primers - genetics Drosophila Proteins Fetal Proteins - genetics Gene Expression Regulation, Developmental GFRα-1 Glial Cell Line-Derived Neurotrophic Factor Receptors Glycoproteins - genetics Hedgehog Proteins Humans Immunohistochemistry In Situ Hybridization Kidney - embryology Kidney - metabolism kidney development Membrane Proteins - genetics Microfilament Proteins Nuclear Proteins - genetics organ culture Organ Culture Techniques Patched Receptors Proteins - genetics Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-ret Rats Receptor Protein-Tyrosine Kinases - genetics Receptors, Cell Surface Recombinant Fusion Proteins - genetics RET Signal Transduction Trans-Activators Transforming Growth Factor beta Wnt Proteins Wnt4 Protein
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