Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits
In this study, polymorphism in the bovine LEPR gene exon 4 was detected by PCR-SSCP and DNA sequencing methods in 653 individuals from five Chinese cattle breeds. Two haplotypes (M and N), three observed genotypes (MM, MN, and NN), and five single nucleotide polymorphisms (SNPs) (NC_007301:g.26767T&...
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| Veröffentlicht in: | Biochemical genetics 2008-12, Vol.46 (11-12), p.828-834 |
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| creator | Guo, Yikun Chen, Hong Lan, Xianyong Zhang, Bao Pan, Chuanying Zhang, Liangzhi Zhang, Cunfang Zhao, Miao |
| description | In this study, polymorphism in the bovine LEPR gene exon 4 was detected by PCR-SSCP and DNA sequencing methods in 653 individuals from five Chinese cattle breeds. Two haplotypes (M and N), three observed genotypes (MM, MN, and NN), and five single nucleotide polymorphisms (SNPs) (NC_007301:g.26767T>C, NC_007301:g.26805C>T, NC_007301:g.27050A>G, NC_007301:g.27063G>A, NC_007301:g.27079G>A) were detected. The frequencies of haplotypes M and N in the five breeds were 0.661-0.747 and 0.253-0.339, respectively. The SNP locus was in Hardy-Weinberg equilibrium in Nanyang, Jiaxian red, Angus, and Jinnan cattle (P > 0.05) and was in Hardy-Weinberg disequilibrium in Qinchuan cattle (P < 0.05). Polymorphism of the LEPR gene was shown to be associated with growth traits in the Nanyang breed. The SNP in the bovine LEPR gene had significant effects on body height, body length, body weight, heart girth, and average daily gain at 6 and 12 months old (P < 0.01 or P < 0.05). Therefore, these results suggest that the LEPR gene is a strong candidate gene that affects growth traits in cattle. |
| doi_str_mv | 10.1007/s10528-008-9197-z |
| format | Article |
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Two haplotypes (M and N), three observed genotypes (MM, MN, and NN), and five single nucleotide polymorphisms (SNPs) (NC_007301:g.26767T>C, NC_007301:g.26805C>T, NC_007301:g.27050A>G, NC_007301:g.27063G>A, NC_007301:g.27079G>A) were detected. The frequencies of haplotypes M and N in the five breeds were 0.661-0.747 and 0.253-0.339, respectively. The SNP locus was in Hardy-Weinberg equilibrium in Nanyang, Jiaxian red, Angus, and Jinnan cattle (P > 0.05) and was in Hardy-Weinberg disequilibrium in Qinchuan cattle (P < 0.05). Polymorphism of the LEPR gene was shown to be associated with growth traits in the Nanyang breed. The SNP in the bovine LEPR gene had significant effects on body height, body length, body weight, heart girth, and average daily gain at 6 and 12 months old (P < 0.01 or P < 0.05). Therefore, these results suggest that the LEPR gene is a strong candidate gene that affects growth traits in cattle.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1007/s10528-008-9197-z</identifier><identifier>PMID: 18807168</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Animals ; Base Sequence ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Body Composition - genetics ; Body height ; Body weight ; Breeding ; Cattle ; Cattle - genetics ; Cattle - growth & development ; Exons ; Genotypes ; Haplotypes ; Human Genetics ; Medical Microbiology ; Molecular Sequence Data ; Polymorphism, Single Nucleotide ; Receptors, Leptin - genetics ; Sequence Analysis, DNA ; Zoology</subject><ispartof>Biochemical genetics, 2008-12, Vol.46 (11-12), p.828-834</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-9069fc308bd0f254454e6b5d341e74ef0e4d1a5a703ee210d1e37914ede6342d3</citedby><cites>FETCH-LOGICAL-c393t-9069fc308bd0f254454e6b5d341e74ef0e4d1a5a703ee210d1e37914ede6342d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10528-008-9197-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10528-008-9197-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18807168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guo, Yikun</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Lan, Xianyong</creatorcontrib><creatorcontrib>Zhang, Bao</creatorcontrib><creatorcontrib>Pan, Chuanying</creatorcontrib><creatorcontrib>Zhang, Liangzhi</creatorcontrib><creatorcontrib>Zhang, Cunfang</creatorcontrib><creatorcontrib>Zhao, Miao</creatorcontrib><title>Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><addtitle>Biochem Genet</addtitle><description>In this study, polymorphism in the bovine LEPR gene exon 4 was detected by PCR-SSCP and DNA sequencing methods in 653 individuals from five Chinese cattle breeds. Two haplotypes (M and N), three observed genotypes (MM, MN, and NN), and five single nucleotide polymorphisms (SNPs) (NC_007301:g.26767T>C, NC_007301:g.26805C>T, NC_007301:g.27050A>G, NC_007301:g.27063G>A, NC_007301:g.27079G>A) were detected. The frequencies of haplotypes M and N in the five breeds were 0.661-0.747 and 0.253-0.339, respectively. The SNP locus was in Hardy-Weinberg equilibrium in Nanyang, Jiaxian red, Angus, and Jinnan cattle (P > 0.05) and was in Hardy-Weinberg disequilibrium in Qinchuan cattle (P < 0.05). Polymorphism of the LEPR gene was shown to be associated with growth traits in the Nanyang breed. The SNP in the bovine LEPR gene had significant effects on body height, body length, body weight, heart girth, and average daily gain at 6 and 12 months old (P < 0.01 or P < 0.05). Therefore, these results suggest that the LEPR gene is a strong candidate gene that affects growth traits in cattle.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Composition - genetics</subject><subject>Body height</subject><subject>Body weight</subject><subject>Breeding</subject><subject>Cattle</subject><subject>Cattle - genetics</subject><subject>Cattle - growth & development</subject><subject>Exons</subject><subject>Genotypes</subject><subject>Haplotypes</subject><subject>Human Genetics</subject><subject>Medical Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Receptors, Leptin - genetics</subject><subject>Sequence Analysis, DNA</subject><subject>Zoology</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9kE1vEzEQhi0EomnhB3ABiwO3hRl_rNfHUpWAiEpF07Pl7M42rpJ1sTet6K-vo41UiQOnseXnfcd6GHuH8BkBzJeMoEVTATSVRWuqxxdshtrISllhXrIZANSVsKI5Ysc535arBaVesyNsGjBYNzP28yLe04ZfXVxmHns-rol_jfdhIL44v_zN51ROfuj4ck0h8dOcYxv8GOLAH8K45vMUH8pYJh_G_Ia96v0m09vDPGHX386XZ9-rxa_5j7PTRdVKK8fKQm37VkKz6qAXWimtqF7pTioko6gHUh167Q1IIoHQIUljUVFHtVSikyfs09R7l-KfHeXRbUNuabPxA8VddrU1eq-hgB__AW_jLg3lb05INFIDigLhBLUp5pyod3cpbH366xDcXrObNLui2e01u8eSeX8o3q221D0nDl4LICYgl6fhhtLz5v-1fphCvY_O36SQ3fWVAJSAWpumNvIJXfKPMA</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Guo, Yikun</creator><creator>Chen, Hong</creator><creator>Lan, Xianyong</creator><creator>Zhang, Bao</creator><creator>Pan, Chuanying</creator><creator>Zhang, Liangzhi</creator><creator>Zhang, Cunfang</creator><creator>Zhao, Miao</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits</title><author>Guo, Yikun ; Chen, Hong ; Lan, Xianyong ; Zhang, Bao ; Pan, Chuanying ; Zhang, Liangzhi ; Zhang, Cunfang ; Zhao, Miao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-9069fc308bd0f254454e6b5d341e74ef0e4d1a5a703ee210d1e37914ede6342d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Composition - genetics</topic><topic>Body height</topic><topic>Body weight</topic><topic>Breeding</topic><topic>Cattle</topic><topic>Cattle - genetics</topic><topic>Cattle - growth & development</topic><topic>Exons</topic><topic>Genotypes</topic><topic>Haplotypes</topic><topic>Human Genetics</topic><topic>Medical Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Receptors, Leptin - genetics</topic><topic>Sequence Analysis, DNA</topic><topic>Zoology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guo, Yikun</creatorcontrib><creatorcontrib>Chen, Hong</creatorcontrib><creatorcontrib>Lan, Xianyong</creatorcontrib><creatorcontrib>Zhang, Bao</creatorcontrib><creatorcontrib>Pan, Chuanying</creatorcontrib><creatorcontrib>Zhang, Liangzhi</creatorcontrib><creatorcontrib>Zhang, Cunfang</creatorcontrib><creatorcontrib>Zhao, Miao</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guo, Yikun</au><au>Chen, Hong</au><au>Lan, Xianyong</au><au>Zhang, Bao</au><au>Pan, Chuanying</au><au>Zhang, Liangzhi</au><au>Zhang, Cunfang</au><au>Zhao, Miao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits</atitle><jtitle>Biochemical genetics</jtitle><stitle>Biochem Genet</stitle><addtitle>Biochem Genet</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>46</volume><issue>11-12</issue><spage>828</spage><epage>834</epage><pages>828-834</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><abstract>In this study, polymorphism in the bovine LEPR gene exon 4 was detected by PCR-SSCP and DNA sequencing methods in 653 individuals from five Chinese cattle breeds. Two haplotypes (M and N), three observed genotypes (MM, MN, and NN), and five single nucleotide polymorphisms (SNPs) (NC_007301:g.26767T>C, NC_007301:g.26805C>T, NC_007301:g.27050A>G, NC_007301:g.27063G>A, NC_007301:g.27079G>A) were detected. The frequencies of haplotypes M and N in the five breeds were 0.661-0.747 and 0.253-0.339, respectively. The SNP locus was in Hardy-Weinberg equilibrium in Nanyang, Jiaxian red, Angus, and Jinnan cattle (P > 0.05) and was in Hardy-Weinberg disequilibrium in Qinchuan cattle (P < 0.05). Polymorphism of the LEPR gene was shown to be associated with growth traits in the Nanyang breed. The SNP in the bovine LEPR gene had significant effects on body height, body length, body weight, heart girth, and average daily gain at 6 and 12 months old (P < 0.01 or P < 0.05). Therefore, these results suggest that the LEPR gene is a strong candidate gene that affects growth traits in cattle.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><pmid>18807168</pmid><doi>10.1007/s10528-008-9197-z</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Base Sequence Biochemistry Biomedical and Life Sciences Biomedicine Body Composition - genetics Body height Body weight Breeding Cattle Cattle - genetics Cattle - growth & development Exons Genotypes Haplotypes Human Genetics Medical Microbiology Molecular Sequence Data Polymorphism, Single Nucleotide Receptors, Leptin - genetics Sequence Analysis, DNA Zoology |
| title | Novel SNPs of the Bovine LEPR Gene and Their Association with Growth Traits |
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