Prospective monitoring of BCR‐ABL1 transcript levels in patients with Philadelphia chromosome‐positive acute lymphoblastic leukaemia undergoing imatinib‐combined chemotherapy

Summary The clinical significance of minimal residual disease (MRD) is uncertain in patients with Philadelphia chromosome‐positive acute lymphoblastic leukaemia (Ph+ ALL) treated with imatinib‐combined chemotherapy. Here we report the results of prospective MRD monitoring in 100 adult patients. Thre...

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Veröffentlicht in:	British journal of haematology 2008-11, Vol.143 (4), p.503-510
Hauptverfasser:	Yanada, Masamitsu, Sugiura, Isamu, Takeuchi, Jin, Akiyama, Hideki, Maruta, Atsuo, Ueda, Yasunori, Usui, Noriko, Yagasaki, Fumiharu, Yujiri, Toshiaki, Takeuchi, Makoto, Nishii, Kazuhiro, Kimura, Yukihiko, Miyawaki, Shuichi, Narimatsu, Hiroto, Miyazaki, Yasushi, Ohtake, Shigeki, Jinnai, Itsuro, Matsuo, Keitaro, Naoe, Tomoki, Ohno, Ryuzo
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lymphoblastic leukaemia Adolescent Adult Antineoplastic Combined Chemotherapy Protocols - therapeutic use BCR‐ABL1 Benzamides Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Disease-Free Survival Female Fusion Proteins, bcr-abl - analysis Fusion Proteins, bcr-abl - genetics Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation Humans imatinib Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged minimal residual disease Neoplasm, Residual Philadelphia chromosome Piperazines - administration & dosage Prognosis Prospective Studies Pyrimidines - administration & dosage Recurrence Reverse Transcriptase Polymerase Chain Reaction - methods Treatment Outcome Young Adult
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