Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE
By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. This synthesis varied during cell NGF-differentiation: the mRNA level decreased during the first 4 days of NGF treatment (NGF 4 days) and then increased during the 3 following...
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| Veröffentlicht in: | Neuroscience letters 1999-04, Vol.265 (2), p.147-150 |
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| container_title | Neuroscience letters |
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| creator | SOULIE, C MITCHELL, V DUPONT-WALLOIS, L CHARTIER-HARLIN, M.-C BEAUVILLAIN, J.-C DELACOURTE, A CAILLET-BOUDIN, M.-L |
| description | By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. This synthesis varied during cell NGF-differentiation: the mRNA level decreased during the first 4 days of NGF treatment (NGF 4 days) and then increased during the 3 following days (NGF 7 days). Furthermore, a treatment of 4-day NGF differentiated cells with exogenous apoE during 3 additional days induced a clear decrease in apoE mRNA synthesis when compared with control cells. This effect was more or less pronounced according to the apoE tested variants: apoE4 was more efficient to decrease the apoE mRNA synthesis as compared with the control cells than apoE3 which was itself more efficient than apoE2. These results suggest that apoE mRNA synthesis in human neuronal-type cells could be regulated by different mechanisms such as those induced by NGF- and apoE-treatments. |
| doi_str_mv | 10.1016/S0304-3940(99)00167-6 |
| format | Article |
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This synthesis varied during cell NGF-differentiation: the mRNA level decreased during the first 4 days of NGF treatment (NGF 4 days) and then increased during the 3 following days (NGF 7 days). Furthermore, a treatment of 4-day NGF differentiated cells with exogenous apoE during 3 additional days induced a clear decrease in apoE mRNA synthesis when compared with control cells. This effect was more or less pronounced according to the apoE tested variants: apoE4 was more efficient to decrease the apoE mRNA synthesis as compared with the control cells than apoE3 which was itself more efficient than apoE2. These results suggest that apoE mRNA synthesis in human neuronal-type cells could be regulated by different mechanisms such as those induced by NGF- and apoE-treatments.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(99)00167-6</identifier><identifier>PMID: 10327190</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>Apolipoproteins E - genetics ; Apolipoproteins E - pharmacology ; Biological and medical sciences ; Cell Differentiation - physiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Isolated neuron and nerve. Neuroglia ; Isomerism ; Nerve Growth Factors - pharmacology ; Neurons - drug effects ; Neurons - metabolism ; Neurons - pathology ; RNA, Messenger - biosynthesis ; Tumor Cells, Cultured - drug effects ; Tumor Cells, Cultured - metabolism ; Tumor Cells, Cultured - pathology ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 1999-04, Vol.265 (2), p.147-150</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-d6d65ddef34b39c3d3478d40c8fc34747e2a1499753e901f14111e4878005e0d3</citedby><cites>FETCH-LOGICAL-c365t-d6d65ddef34b39c3d3478d40c8fc34747e2a1499753e901f14111e4878005e0d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1777544$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10327190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SOULIE, C</creatorcontrib><creatorcontrib>MITCHELL, V</creatorcontrib><creatorcontrib>DUPONT-WALLOIS, L</creatorcontrib><creatorcontrib>CHARTIER-HARLIN, M.-C</creatorcontrib><creatorcontrib>BEAUVILLAIN, J.-C</creatorcontrib><creatorcontrib>DELACOURTE, A</creatorcontrib><creatorcontrib>CAILLET-BOUDIN, M.-L</creatorcontrib><title>Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. This synthesis varied during cell NGF-differentiation: the mRNA level decreased during the first 4 days of NGF treatment (NGF 4 days) and then increased during the 3 following days (NGF 7 days). Furthermore, a treatment of 4-day NGF differentiated cells with exogenous apoE during 3 additional days induced a clear decrease in apoE mRNA synthesis when compared with control cells. This effect was more or less pronounced according to the apoE tested variants: apoE4 was more efficient to decrease the apoE mRNA synthesis as compared with the control cells than apoE3 which was itself more efficient than apoE2. These results suggest that apoE mRNA synthesis in human neuronal-type cells could be regulated by different mechanisms such as those induced by NGF- and apoE-treatments.</description><subject>Apolipoproteins E - genetics</subject><subject>Apolipoproteins E - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Differentiation - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Isomerism</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - metabolism</subject><subject>Tumor Cells, Cultured - pathology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUhi0EokPhEUBeINQuAnZ8i5ejaqCIqkgEFl1ZHvukE5TYqZ2A5gl4bZKZEbBj5SPr-89FH0IvKXlLCZXvasIIL5jm5ELrSzJ_qUI-QitaqbJQWpWP0eoPcoae5fydECKo4E_RGSWsVFSTFfpV78O4g9xmHBtsh9i1QxxSHKENeIMv1kPcXOL-y-0ab_d4N_U24ABTisF2xbgfANef8C2ur4v6Dos77KDrMrbB43bMOMH91NmxjWFJB0g_AN-n-HPc4ca6MaYDucx4jp40tsvw4vSeo2_vN1-vroubzx8-Xq1vCsekGAsvvRTeQ8P4lmnHPOOq8py4qnFzyRWUlnKtlWCgCW0op5QCr1Q13w7Es3P05th3vvFhgjyavs3L0jZAnLKRc5RoSf4LUsW0rEoxg-IIuhRzTtCYIbW9TXtDiVlUmYMqs3gwWpuDKiPn3KvTgGnbg_8ndXQzA69PgM3Odk2ywbX5L6eUEpyz32gvmf8</recordid><startdate>19990416</startdate><enddate>19990416</enddate><creator>SOULIE, C</creator><creator>MITCHELL, V</creator><creator>DUPONT-WALLOIS, L</creator><creator>CHARTIER-HARLIN, M.-C</creator><creator>BEAUVILLAIN, J.-C</creator><creator>DELACOURTE, A</creator><creator>CAILLET-BOUDIN, M.-L</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990416</creationdate><title>Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE</title><author>SOULIE, C ; MITCHELL, V ; DUPONT-WALLOIS, L ; CHARTIER-HARLIN, M.-C ; BEAUVILLAIN, J.-C ; DELACOURTE, A ; CAILLET-BOUDIN, M.-L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-d6d65ddef34b39c3d3478d40c8fc34747e2a1499753e901f14111e4878005e0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Apolipoproteins E - genetics</topic><topic>Apolipoproteins E - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Differentiation - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Isomerism</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Tumor Cells, Cultured - drug effects</topic><topic>Tumor Cells, Cultured - metabolism</topic><topic>Tumor Cells, Cultured - pathology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SOULIE, C</creatorcontrib><creatorcontrib>MITCHELL, V</creatorcontrib><creatorcontrib>DUPONT-WALLOIS, L</creatorcontrib><creatorcontrib>CHARTIER-HARLIN, M.-C</creatorcontrib><creatorcontrib>BEAUVILLAIN, J.-C</creatorcontrib><creatorcontrib>DELACOURTE, A</creatorcontrib><creatorcontrib>CAILLET-BOUDIN, M.-L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SOULIE, C</au><au>MITCHELL, V</au><au>DUPONT-WALLOIS, L</au><au>CHARTIER-HARLIN, M.-C</au><au>BEAUVILLAIN, J.-C</au><au>DELACOURTE, A</au><au>CAILLET-BOUDIN, M.-L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1999-04-16</date><risdate>1999</risdate><volume>265</volume><issue>2</issue><spage>147</spage><epage>150</epage><pages>147-150</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>By in situ hybridization, we show the ability of human neuroblastoma SY 5Y cells to synthesize apolipoprotein E (apoE) mRNA. This synthesis varied during cell NGF-differentiation: the mRNA level decreased during the first 4 days of NGF treatment (NGF 4 days) and then increased during the 3 following days (NGF 7 days). Furthermore, a treatment of 4-day NGF differentiated cells with exogenous apoE during 3 additional days induced a clear decrease in apoE mRNA synthesis when compared with control cells. This effect was more or less pronounced according to the apoE tested variants: apoE4 was more efficient to decrease the apoE mRNA synthesis as compared with the control cells than apoE3 which was itself more efficient than apoE2. These results suggest that apoE mRNA synthesis in human neuronal-type cells could be regulated by different mechanisms such as those induced by NGF- and apoE-treatments.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>10327190</pmid><doi>10.1016/S0304-3940(99)00167-6</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1999-04, Vol.265 (2), p.147-150 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Apolipoproteins E - genetics Apolipoproteins E - pharmacology Biological and medical sciences Cell Differentiation - physiology Fundamental and applied biological sciences. Psychology Humans Isolated neuron and nerve. Neuroglia Isomerism Nerve Growth Factors - pharmacology Neurons - drug effects Neurons - metabolism Neurons - pathology RNA, Messenger - biosynthesis Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Cells, Cultured - pathology Vertebrates: nervous system and sense organs |
| title | Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE |
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