Prostaglandin E2 Inhibits Eosinophil Trafficking through E-Prostanoid 2 Receptors

The accumulation of eosinophils in lung tissue is a hallmark of asthma, and it is believed that eosinophils play a crucial pathogenic role in allergic inflammation. Prostaglandin (PG) E(2) exerts anti-inflammatory and bronchoprotective mechanisms in asthma, but the underlying mechanisms have remaine...

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Veröffentlicht in:	The Journal of immunology (1950) 2008-11, Vol.181 (10), p.7273-7283
Hauptverfasser:	Sturm, Eva M, Schratl, Petra, Schuligoi, Rufina, Konya, Viktoria, Sturm, Gunter J, Lippe, Irmgard Th, Peskar, Bernhard A, Heinemann, Akos
Format:	Artikel
Sprache:	eng
Schlagworte:	Alprostadil - analogs & derivatives Alprostadil - pharmacology Animals Cells, Cultured Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology Dinoprostone - immunology Dinoprostone - metabolism Enzyme Inhibitors - pharmacology Eosinophils - drug effects Eosinophils - immunology Eosinophils - metabolism Guinea Pigs Humans Immunohistochemistry Mice Phosphatidylinositol 3-Kinases - immunology Phosphatidylinositol 3-Kinases - metabolism Protein Kinase C - immunology Protein Kinase C - metabolism Receptors, Prostaglandin E - immunology Receptors, Prostaglandin E - metabolism Receptors, Prostaglandin E, EP2 Subtype
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