Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling
The collagen-binding motif (CBM) peptide, a cleavage product of osteopontin (OPN), stimulated intracellular calcium increase in human neutrophils. CBM peptide-stimulated calcium was inhibited by pertussis toxin (PTX), suggesting the influence of PTX-sensitive G-proteins. In addition CBM peptide stim...
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| Veröffentlicht in: | FEBS letters 2008-10, Vol.582 (23-24), p.3379-3384 |
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| creator | Kim, Mi-Kyoung Kim, Sang Doo Lee, Ha Young Lee, Sun Young Shim, Jae Woong Yun, Jeanho Kim, Jong-Min Min, Do Sik Yoo, Young Hyun Bae, Yoe-Sik |
| description | The collagen-binding motif (CBM) peptide, a cleavage product of osteopontin (OPN), stimulated intracellular calcium increase in human neutrophils. CBM peptide-stimulated calcium was inhibited by pertussis toxin (PTX), suggesting the influence of PTX-sensitive G-proteins. In addition CBM peptide stimulated the chemotactic migration of human neutrophils and human monocytes. CBM peptide-induced neutrophil chemotaxis was completely inhibited by PTX, once again indicating the influence of Gi proteins. CBM peptide was also found to induce mitogen activated protein kinase activation. CBM peptide-induced neutrophil chemotaxis was mediated by p38 kinase as well as an extracellular signal-regulated protein kinase. Taken together, the results suggest that a cleavage product of OPN, CBM peptide, initiates immune responses by inducing neutrophil trafficking via certain PTX-sensitive cell surface receptors. |
| doi_str_mv | 10.1016/j.febslet.2008.09.023 |
| format | Article |
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CBM peptide-stimulated calcium was inhibited by pertussis toxin (PTX), suggesting the influence of PTX-sensitive G-proteins. In addition CBM peptide stimulated the chemotactic migration of human neutrophils and human monocytes. CBM peptide-induced neutrophil chemotaxis was completely inhibited by PTX, once again indicating the influence of Gi proteins. CBM peptide was also found to induce mitogen activated protein kinase activation. CBM peptide-induced neutrophil chemotaxis was mediated by p38 kinase as well as an extracellular signal-regulated protein kinase. Taken together, the results suggest that a cleavage product of OPN, CBM peptide, initiates immune responses by inducing neutrophil trafficking via certain PTX-sensitive cell surface receptors.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2008.09.023</identifier><identifier>PMID: 18804464</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>[Ca2+]i ; Amino Acid Motifs ; CBM ; CBM peptide ; Cells, Cultured ; Chemotaxis ; Collagen - metabolism ; collagen-binding motif ; ERK ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Extracellular signal-regulated protein kinase ; FBS ; fetal bovine serum ; GTP-Binding Proteins - antagonists & inhibitors ; GTP-Binding Proteins - metabolism ; Humans ; intracellular calcium concentration ; MAPK ; mitogen activated protein kinase ; Neutrophil ; Neutrophils - drug effects ; Neutrophils - immunology ; OPN ; osteopontin ; Osteopontin - metabolism ; Osteopontin - pharmacology ; Peptide Fragments - metabolism ; Peptide Fragments - pharmacology ; pertussis toxin ; Pertussis Toxin - pharmacology ; Pertussis toxin-sensitive G-protein ; PTX</subject><ispartof>FEBS letters, 2008-10, Vol.582 (23-24), p.3379-3384</ispartof><rights>2008 Federation of European Biochemical Societies</rights><rights>FEBS Letters 582 (2008) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5256-e59cc1fd38030f12a57570507f5e1cbd11c8303602426f60f85b9dfd574f41613</citedby><cites>FETCH-LOGICAL-c5256-e59cc1fd38030f12a57570507f5e1cbd11c8303602426f60f85b9dfd574f41613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2008.09.023$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.febslet.2008.09.023$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,1433,3550,27924,27925,45574,45575,45995,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18804464$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Mi-Kyoung</creatorcontrib><creatorcontrib>Kim, Sang Doo</creatorcontrib><creatorcontrib>Lee, Ha Young</creatorcontrib><creatorcontrib>Lee, Sun Young</creatorcontrib><creatorcontrib>Shim, Jae Woong</creatorcontrib><creatorcontrib>Yun, Jeanho</creatorcontrib><creatorcontrib>Kim, Jong-Min</creatorcontrib><creatorcontrib>Min, Do Sik</creatorcontrib><creatorcontrib>Yoo, Young Hyun</creatorcontrib><creatorcontrib>Bae, Yoe-Sik</creatorcontrib><title>Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>The collagen-binding motif (CBM) peptide, a cleavage product of osteopontin (OPN), stimulated intracellular calcium increase in human neutrophils. CBM peptide-stimulated calcium was inhibited by pertussis toxin (PTX), suggesting the influence of PTX-sensitive G-proteins. In addition CBM peptide stimulated the chemotactic migration of human neutrophils and human monocytes. CBM peptide-induced neutrophil chemotaxis was completely inhibited by PTX, once again indicating the influence of Gi proteins. CBM peptide was also found to induce mitogen activated protein kinase activation. CBM peptide-induced neutrophil chemotaxis was mediated by p38 kinase as well as an extracellular signal-regulated protein kinase. Taken together, the results suggest that a cleavage product of OPN, CBM peptide, initiates immune responses by inducing neutrophil trafficking via certain PTX-sensitive cell surface receptors.</description><subject>[Ca2+]i</subject><subject>Amino Acid Motifs</subject><subject>CBM</subject><subject>CBM peptide</subject><subject>Cells, Cultured</subject><subject>Chemotaxis</subject><subject>Collagen - metabolism</subject><subject>collagen-binding motif</subject><subject>ERK</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Extracellular signal-regulated protein kinase</subject><subject>FBS</subject><subject>fetal bovine serum</subject><subject>GTP-Binding Proteins - antagonists & inhibitors</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Humans</subject><subject>intracellular calcium concentration</subject><subject>MAPK</subject><subject>mitogen activated protein kinase</subject><subject>Neutrophil</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - immunology</subject><subject>OPN</subject><subject>osteopontin</subject><subject>Osteopontin - metabolism</subject><subject>Osteopontin - pharmacology</subject><subject>Peptide Fragments - metabolism</subject><subject>Peptide Fragments - pharmacology</subject><subject>pertussis toxin</subject><subject>Pertussis Toxin - pharmacology</subject><subject>Pertussis toxin-sensitive G-protein</subject><subject>PTX</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks1u1DAUhSMEokPhEUBesWrCdRInzgrRUX-QKrEA1pZjX894lNghdob2fXhQHM1ILMvKuta5n4_OcZa9p1BQoM2nQ2GwDwPGogTgBXQFlNWLbEN5W-VV3fCX2QaA1jlru-oiexPCAdLMafc6u6CcQ1039Sb7s_XDIHfo8t46bd2OjD5aQyacotV4RSRRA8pjkpBp9npRkXhDfIjoJ--idVckRDsug4wYyH4ZpSMOlzj7aW8HovaYgPLRBnK0MmHnuISQpugfrcsDumCjPSK5W_ER092I2iaYJsHunBySp7fZKyOHgO_O52X28_bmx_Y-f_h293X75SFXrGRNjqxTihpdcajA0FKylrXAoDUMqeo1pYpXUDVQ1mVjGjCc9Z02mrW1qWlDq8vs44mbrPxaMEQx2qAwBeTQL0E0XVtz3jbPCksKVZcCTkJ2EqrZhzCjEdNsRzk_CQpi7VEcxLlHsfYooBOpx7T34fzA0qc8_m2di0uC-5Pgtx3w6f-o4vbmuvy-for1TwAHSPmsHj-fUJiiPVqcRVAWnUo1zKii0N4-4_YvpsbK1Q</recordid><startdate>20081015</startdate><enddate>20081015</enddate><creator>Kim, Mi-Kyoung</creator><creator>Kim, Sang Doo</creator><creator>Lee, Ha Young</creator><creator>Lee, Sun Young</creator><creator>Shim, Jae Woong</creator><creator>Yun, Jeanho</creator><creator>Kim, Jong-Min</creator><creator>Min, Do Sik</creator><creator>Yoo, Young Hyun</creator><creator>Bae, Yoe-Sik</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T5</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081015</creationdate><title>Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling</title><author>Kim, Mi-Kyoung ; Kim, Sang Doo ; Lee, Ha Young ; Lee, Sun Young ; Shim, Jae Woong ; Yun, Jeanho ; Kim, Jong-Min ; Min, Do Sik ; Yoo, Young Hyun ; Bae, Yoe-Sik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5256-e59cc1fd38030f12a57570507f5e1cbd11c8303602426f60f85b9dfd574f41613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>[Ca2+]i</topic><topic>Amino Acid Motifs</topic><topic>CBM</topic><topic>CBM peptide</topic><topic>Cells, Cultured</topic><topic>Chemotaxis</topic><topic>Collagen - metabolism</topic><topic>collagen-binding motif</topic><topic>ERK</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Extracellular signal-regulated protein kinase</topic><topic>FBS</topic><topic>fetal bovine serum</topic><topic>GTP-Binding Proteins - antagonists & inhibitors</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Humans</topic><topic>intracellular calcium concentration</topic><topic>MAPK</topic><topic>mitogen activated protein kinase</topic><topic>Neutrophil</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - immunology</topic><topic>OPN</topic><topic>osteopontin</topic><topic>Osteopontin - metabolism</topic><topic>Osteopontin - pharmacology</topic><topic>Peptide Fragments - metabolism</topic><topic>Peptide Fragments - pharmacology</topic><topic>pertussis toxin</topic><topic>Pertussis Toxin - pharmacology</topic><topic>Pertussis toxin-sensitive G-protein</topic><topic>PTX</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Mi-Kyoung</creatorcontrib><creatorcontrib>Kim, Sang Doo</creatorcontrib><creatorcontrib>Lee, Ha Young</creatorcontrib><creatorcontrib>Lee, Sun Young</creatorcontrib><creatorcontrib>Shim, Jae Woong</creatorcontrib><creatorcontrib>Yun, Jeanho</creatorcontrib><creatorcontrib>Kim, Jong-Min</creatorcontrib><creatorcontrib>Min, Do Sik</creatorcontrib><creatorcontrib>Yoo, Young Hyun</creatorcontrib><creatorcontrib>Bae, Yoe-Sik</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Mi-Kyoung</au><au>Kim, Sang Doo</au><au>Lee, Ha Young</au><au>Lee, Sun Young</au><au>Shim, Jae Woong</au><au>Yun, Jeanho</au><au>Kim, Jong-Min</au><au>Min, Do Sik</au><au>Yoo, Young Hyun</au><au>Bae, Yoe-Sik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2008-10-15</date><risdate>2008</risdate><volume>582</volume><issue>23-24</issue><spage>3379</spage><epage>3384</epage><pages>3379-3384</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>The collagen-binding motif (CBM) peptide, a cleavage product of osteopontin (OPN), stimulated intracellular calcium increase in human neutrophils. CBM peptide-stimulated calcium was inhibited by pertussis toxin (PTX), suggesting the influence of PTX-sensitive G-proteins. In addition CBM peptide stimulated the chemotactic migration of human neutrophils and human monocytes. CBM peptide-induced neutrophil chemotaxis was completely inhibited by PTX, once again indicating the influence of Gi proteins. CBM peptide was also found to induce mitogen activated protein kinase activation. CBM peptide-induced neutrophil chemotaxis was mediated by p38 kinase as well as an extracellular signal-regulated protein kinase. Taken together, the results suggest that a cleavage product of OPN, CBM peptide, initiates immune responses by inducing neutrophil trafficking via certain PTX-sensitive cell surface receptors.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>18804464</pmid><doi>10.1016/j.febslet.2008.09.023</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | [Ca2+]i Amino Acid Motifs CBM CBM peptide Cells, Cultured Chemotaxis Collagen - metabolism collagen-binding motif ERK Extracellular Signal-Regulated MAP Kinases - metabolism Extracellular signal-regulated protein kinase FBS fetal bovine serum GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - metabolism Humans intracellular calcium concentration MAPK mitogen activated protein kinase Neutrophil Neutrophils - drug effects Neutrophils - immunology OPN osteopontin Osteopontin - metabolism Osteopontin - pharmacology Peptide Fragments - metabolism Peptide Fragments - pharmacology pertussis toxin Pertussis Toxin - pharmacology Pertussis toxin-sensitive G-protein PTX |
| title | Collagen-binding motif peptide, a cleavage product of osteopontin, stimulates human neutrophil chemotaxis via pertussis toxin-sensitive G protein-mediated signaling |
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