Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects

Folic acid administration to women in the periconceptional period reduces the occurrence of neural tube defects (NTDs) in their offspring. A polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), 677C→12;T, is the first genetic risk factor for NTDs in man identified at the mo...

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Veröffentlicht in:	American journal of medical genetics 1999-05, Vol.84 (2), p.151-157
Hauptverfasser:	Christensen, Benedicte, Arbour, Laura, Tran, Pamela, Leclerc, Daniel, Sabbaghian, Nelly, Platt, Robert, Gilfix, Brian M., Rosenblatt, David S., Gravel, Roy A., Forbes, Patricia, Rozen, Rima
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics Adolescent Adult Biological and medical sciences Child Child, Preschool Erythrocytes - metabolism Female folate Folic Acid - blood Genotype homocysteine Homocysteine - blood Humans Infant Male Malformations of the nervous system Medical sciences methionine synthase methylenetetrahydrofolate reductase Methylenetetrahydrofolate Reductase (NADPH2) Middle Aged neural tube defects Neural Tube Defects - genetics Neurology Oxidoreductases Acting on CH-NH Group Donors - genetics Polymorphism, Genetic Polymorphism, Restriction Fragment Length Prevalence Risk Vitamin B 12 - blood
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