Phosphoproteomics, oncogenic signaling and cancer research
The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as...
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| Veröffentlicht in: | Proteomics (Weinheim) 2008-11, Vol.8 (21), p.4370-4382 |
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| container_title | Proteomics (Weinheim) |
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| creator | Chong, Poh-Kuan Lee, Huiyin Kong, Jacklyn Wai-Fun Loh, Marie Chiew-Shia Wong, Chee-Hong Lim, Yoon-Pin |
| description | The past 5 years have seen an explosion of phosphoproteomics methods development. In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. Such a phenomenon is already happening as exemplified by its use in promoting the understanding of the molecular etiology of cancer and target-directed therapeutics. |
| doi_str_mv | 10.1002/pmic.200800051 |
| format | Article |
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In this review, using epidermal growth-factor signaling as a model, we will discuss how phosphoproteomics, along with bioinformatics and computational modeling, have impacted key aspects of oncogenic signaling such as in the temporal fine mapping of phosphorylation events, and the identification of novel tyrosine kinase substrates and phosphorylation sites. We submit that the next decade will see considerable exploitation of phosphoproteomics in cancer research. 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Lee, Huiyin ; Kong, Jacklyn Wai-Fun ; Loh, Marie Chiew-Shia ; Wong, Chee-Hong ; Lim, Yoon-Pin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4051-b59960a9a787b1483bbc3914687a010fbbe3aaa44c63a25d976547bd204cdde13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Cancer</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Computational Biology</topic><topic>Computer Simulation</topic><topic>Epidermal Growth Factor - genetics</topic><topic>Epidermal Growth Factor - physiology</topic><topic>Epidermal growth factor receptor</topic><topic>Humans</topic><topic>Neoplasms - genetics</topic><topic>Neoplasms - metabolism</topic><topic>Oncogenes - physiology</topic><topic>Phosphoproteins - physiology</topic><topic>Phosphoproteomics</topic><topic>Phosphorylation</topic><topic>Proteomics - methods</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Receptor, Epidermal Growth Factor - physiology</topic><topic>Signal Transduction</topic><topic>Tyrosine kinase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chong, Poh-Kuan</creatorcontrib><creatorcontrib>Lee, Huiyin</creatorcontrib><creatorcontrib>Kong, Jacklyn Wai-Fun</creatorcontrib><creatorcontrib>Loh, Marie Chiew-Shia</creatorcontrib><creatorcontrib>Wong, Chee-Hong</creatorcontrib><creatorcontrib>Lim, Yoon-Pin</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Proteomics (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chong, Poh-Kuan</au><au>Lee, Huiyin</au><au>Kong, Jacklyn Wai-Fun</au><au>Loh, Marie Chiew-Shia</au><au>Wong, Chee-Hong</au><au>Lim, Yoon-Pin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phosphoproteomics, oncogenic signaling and cancer research</atitle><jtitle>Proteomics (Weinheim)</jtitle><addtitle>Proteomics</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>8</volume><issue>21</issue><spage>4370</spage><epage>4382</epage><pages>4370-4382</pages><issn>1615-9853</issn><eissn>1615-9861</eissn><abstract>The past 5 years have seen an explosion of phosphoproteomics methods development. 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| subjects | Animals Cancer Cell Transformation, Neoplastic - metabolism Computational Biology Computer Simulation Epidermal Growth Factor - genetics Epidermal Growth Factor - physiology Epidermal growth factor receptor Humans Neoplasms - genetics Neoplasms - metabolism Oncogenes - physiology Phosphoproteins - physiology Phosphoproteomics Phosphorylation Proteomics - methods Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Signal Transduction Tyrosine kinase |
| title | Phosphoproteomics, oncogenic signaling and cancer research |
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