Hyper IgE syndrome: an update on clinical aspects and the role of signal transducer and activator of transcription 3

PURPOSE OF REVIEWHyper IgE syndrome (HIES) is a primary immunodeficiency characterized by eczema, recurrent skin and lung infections, elevated serum IgE, and connective tissue and skeletal abnormalities. We present newly recognized aspects of the clinical phenotype and discuss recent genetic and imm...

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