Inactivating mutations and overexpression of BCL10 , a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

Mucosa-associated lymphoid tissue (MALT) lymphomas most frequently involve the gastrointestinal tract and are the most common subset of extranodal non-Hodgkin lymphoma 1 (NHL). Here we describe overexpression of BCL10 , a novel apoptotic signalling gene that encodes an amino-terminal caspase recruit...

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Veröffentlicht in:	Nature genetics 1999-05, Vol.22 (1), p.63-68
Hauptverfasser:	Weisenburger, Dennis D, Vesely, Michael, Rakestraw, Karen M, Nowotny, Hadwiga, Rosenthal, André, Callet-Bauchu, Evelyne, Sanger, Warren G, Schlegelberger, Brigitte, Beckmann, Georg, Morris, Stephan W, Naeve, Clayton W, Yan, Minhong, Siebert, Reiner, Hinzmann, Bernd, Zhang, Quangeng, Salles, Gilles, Dixit, Vishva M, Xue, Liquan, Cui, Xiaoli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Agriculture Amino Acid Sequence Animal Genetics and Genomics B-Cell CLL-Lymphoma 10 Protein Binding Sites Biological and medical sciences Biomedical and Life Sciences Biomedicine Blotting, Northern Cancer Research Caspases - metabolism Cell Death - genetics Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 14 - genetics DNA - chemistry DNA - genetics Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene Function Human Genetics Humans In Situ Hybridization, Fluorescence letter Lymphoma, B-Cell, Marginal Zone - genetics Male Molecular and cellular biology Molecular Sequence Data Mutation Neoplasm Proteins - chemistry Neoplasm Proteins - genetics Neoplasm Proteins - metabolism NF-kappa B - metabolism Protein Structure, Tertiary Sequence Alignment Sequence Analysis, DNA Sequence Homology, Amino Acid Tissue Distribution Translocation, Genetic Tumor Cells, Cultured
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