Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls
To determine the presence and distribution of cerebrovascular Aβ production we investigated amyloid β precursor protein (AβPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, A...
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| Veröffentlicht in: | Brain research 1999-05, Vol.828 (1), p.179-183 |
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| creator | Natté, Remco de Boer, Willem I. Maat-Schieman, Marion L.C. Baelde, Hans J. Vinters, Harry V. Roos, Raymund A.C. van Duinen, Sjoerd G. |
| description | To determine the presence and distribution of cerebrovascular Aβ production we investigated amyloid β precursor protein (AβPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AβPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AβPP-mRNA. AβPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AβPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Aβ to cerebrovascular amyloidosis. |
| doi_str_mv | 10.1016/S0006-8993(99)01361-X |
| format | Article |
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In all subjects, AβPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AβPP-mRNA. AβPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AβPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Aβ to cerebrovascular amyloidosis.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(99)01361-X</identifier><identifier>PMID: 10320740</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - genetics ; Alzheimer Disease - metabolism ; Alzheimer's disease ; Amyloid beta-Protein Precursor - genetics ; Amyloid β precursor protein ; Biological and medical sciences ; Brain - blood supply ; Brain - metabolism ; Cerebral amyloid angiopathy ; Cerebral Amyloid Angiopathy - genetics ; Cerebral Amyloid Angiopathy - metabolism ; Cerebral Angiography ; Cerebral Arteries - chemistry ; Cerebral Arteries - physiology ; Cerebral Hemorrhage - genetics ; Cerebral Hemorrhage - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Gene Expression ; HCHWA-D ; Humans ; In Situ Hybridization ; Medical sciences ; Middle Aged ; Neurology ; RNA, Messenger - analysis</subject><ispartof>Brain research, 1999-05, Vol.828 (1), p.179-183</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-5a6c69e0b8c497f486f9354f565cd1e41148b4d840668dcccf012764866bd66a3</citedby><cites>FETCH-LOGICAL-c421t-5a6c69e0b8c497f486f9354f565cd1e41148b4d840668dcccf012764866bd66a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0006-8993(99)01361-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1803162$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10320740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Natté, Remco</creatorcontrib><creatorcontrib>de Boer, Willem I.</creatorcontrib><creatorcontrib>Maat-Schieman, Marion L.C.</creatorcontrib><creatorcontrib>Baelde, Hans J.</creatorcontrib><creatorcontrib>Vinters, Harry V.</creatorcontrib><creatorcontrib>Roos, Raymund A.C.</creatorcontrib><creatorcontrib>van Duinen, Sjoerd G.</creatorcontrib><title>Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>To determine the presence and distribution of cerebrovascular Aβ production we investigated amyloid β precursor protein (AβPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AβPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AβPP-mRNA. AβPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AβPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Aβ to cerebrovascular amyloidosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's disease</subject><subject>Amyloid beta-Protein Precursor - genetics</subject><subject>Amyloid β precursor protein</subject><subject>Biological and medical sciences</subject><subject>Brain - blood supply</subject><subject>Brain - metabolism</subject><subject>Cerebral amyloid angiopathy</subject><subject>Cerebral Amyloid Angiopathy - genetics</subject><subject>Cerebral Amyloid Angiopathy - metabolism</subject><subject>Cerebral Angiography</subject><subject>Cerebral Arteries - chemistry</subject><subject>Cerebral Arteries - physiology</subject><subject>Cerebral Hemorrhage - genetics</subject><subject>Cerebral Hemorrhage - metabolism</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Gene Expression</subject><subject>HCHWA-D</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>RNA, Messenger - analysis</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQQK0K1C6FTyjKAVVwSPHEziQ-VauKFqSKSgWk3izHnrRGzqa1k0J_iw_hm_B2V8Ctp5nRvBmPnhk7AH4EHPD9F845lq1S4q1S7zgIhPJqhy2gbaoSK8mfscVfZI-9SOl7LoVQfJftARcVbyRfsIvl8BBG74rfv4rbSHaOaYw5Gyfyq3K4_LwsfCroZ-6lRK6YbuI4X9-M81RYitRFE4r7dSsUP0wI6SV73puQ6NU27rNvpx--nnwszy_OPp0sz0srK5jK2qBFRbxrrVRNL1vslahlX2NtHZAEkG0nXSs5YuustT2HqsHMYecQjdhnh5u9-dS7mdKkB58shWBWNM5Jo2okqhqeBKGpFCCKDNYb0MYxpUi9vo1-MPFBA9dr5fpRuV771ErpR-X6Ks-93j4wdwO5_6Y2jjPwZguYZE3oo1lZn_5xLReAVcaONxhlbfeeok7W08qS8_lfJu1G_8QlfwCh4p38</recordid><startdate>19990515</startdate><enddate>19990515</enddate><creator>Natté, Remco</creator><creator>de Boer, Willem I.</creator><creator>Maat-Schieman, Marion L.C.</creator><creator>Baelde, Hans J.</creator><creator>Vinters, Harry V.</creator><creator>Roos, Raymund A.C.</creator><creator>van Duinen, Sjoerd G.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19990515</creationdate><title>Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls</title><author>Natté, Remco ; de Boer, Willem I. ; Maat-Schieman, Marion L.C. ; Baelde, Hans J. ; Vinters, Harry V. ; Roos, Raymund A.C. ; van Duinen, Sjoerd G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-5a6c69e0b8c497f486f9354f565cd1e41148b4d840668dcccf012764866bd66a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's disease</topic><topic>Amyloid beta-Protein Precursor - genetics</topic><topic>Amyloid β precursor protein</topic><topic>Biological and medical sciences</topic><topic>Brain - blood supply</topic><topic>Brain - metabolism</topic><topic>Cerebral amyloid angiopathy</topic><topic>Cerebral Amyloid Angiopathy - genetics</topic><topic>Cerebral Amyloid Angiopathy - metabolism</topic><topic>Cerebral Angiography</topic><topic>Cerebral Arteries - chemistry</topic><topic>Cerebral Arteries - physiology</topic><topic>Cerebral Hemorrhage - genetics</topic><topic>Cerebral Hemorrhage - metabolism</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Gene Expression</topic><topic>HCHWA-D</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>RNA, Messenger - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natté, Remco</creatorcontrib><creatorcontrib>de Boer, Willem I.</creatorcontrib><creatorcontrib>Maat-Schieman, Marion L.C.</creatorcontrib><creatorcontrib>Baelde, Hans J.</creatorcontrib><creatorcontrib>Vinters, Harry V.</creatorcontrib><creatorcontrib>Roos, Raymund A.C.</creatorcontrib><creatorcontrib>van Duinen, Sjoerd G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natté, Remco</au><au>de Boer, Willem I.</au><au>Maat-Schieman, Marion L.C.</au><au>Baelde, Hans J.</au><au>Vinters, Harry V.</au><au>Roos, Raymund A.C.</au><au>van Duinen, Sjoerd G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1999-05-15</date><risdate>1999</risdate><volume>828</volume><issue>1</issue><spage>179</spage><epage>183</epage><pages>179-183</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>To determine the presence and distribution of cerebrovascular Aβ production we investigated amyloid β precursor protein (AβPP)-mRNA expression by RNA in situ hybridization in patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type, Alzheimer disease and controls. In all subjects, AβPP-mRNA was expressed in endothelial cells, smooth muscle cells, adventitial cells and brain pericytes and/or perivascular cells. Meningeal cells also expressed AβPP-mRNA. AβPP was detected in endothelial cells, smooth muscle cells and adventitial cells. The demonstration of AβPP-mRNA at all vascular sites where amyloid formation can occur supports an important contribution of locally derived Aβ to cerebrovascular amyloidosis.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>10320740</pmid><doi>10.1016/S0006-8993(99)01361-X</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Protein Precursor - genetics Amyloid β precursor protein Biological and medical sciences Brain - blood supply Brain - metabolism Cerebral amyloid angiopathy Cerebral Amyloid Angiopathy - genetics Cerebral Amyloid Angiopathy - metabolism Cerebral Angiography Cerebral Arteries - chemistry Cerebral Arteries - physiology Cerebral Hemorrhage - genetics Cerebral Hemorrhage - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Gene Expression HCHWA-D Humans In Situ Hybridization Medical sciences Middle Aged Neurology RNA, Messenger - analysis |
| title | Amyloid β precursor protein-mRNA is expressed throughout cerebral vessel walls |
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