Selective, Covalent Modification of β -Tubulin Residue Cys-239 by T138067, an Antitumor Agent with in vivo Efficacy against Multidrug-Resistant Tumors

Microtubules are linear polymers of α - and β -tubulin heterodimers and are the major constituents of mitotic spindles, which are essential for the separation of chromosomes during mitosis. Here we describe a synthetic compound, 2-fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene (T138067), whi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1999-05, Vol.96 (10), p.5686-5691
Hauptverfasser:	Shan, Bei, Medina, Julio C., Santha, Edit, Frankmoelle, Walter P., Ting-C. Chou, Learned, Robert M., Narbut, Mathew R., Stott, Dean, Wu, Pengguang, Jaen, Juan C., Rosen, Terry, Pieter B. M. W. M. Timmermans, Beckmann, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Animals Antineoplastic Agents - pharmacology Apoptosis - drug effects b-tubulin Biological Sciences Cell Cycle - drug effects Cell growth Cell lines Cellular biology Cysteine - chemistry Cytoskeleton - drug effects Diploidy Drug resistance Drug Resistance, Multiple Heterologous transplantation Humans Isotypes Leukemia, Lymphoid - drug therapy Medical research Mice Mice, Nude Microtubules Microtubules - metabolism Molecular Structure Neoplasm Transplantation Paclitaxel - pharmacology Polymerization Protein Binding Sulfonamides - chemical synthesis Sulfonamides - pharmacology Tubulin - chemistry Tumor cell line Tumor Cells, Cultured Tumors Vinblastine - pharmacology
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