Epidermal growth factor receptor function is necessary for normal craniofacial development and palate closure

Craniofacial malformations are among the most frequent congenital birth defects in humans; cleft palate, that is inadequate fusion of the palatal shelves, occurs with an annual incidence of 1 in 700 to 1 in 1,000 live births among individuals of European descent 1 . The secondary palate arises as bi...

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Veröffentlicht in:	Nature genetics 1999-05, Vol.22 (1), p.69-73
Hauptverfasser:	Miettinen, Päivi J, Chin, Jennie R, Shum, Lillian, Slavkin, Harold C, Shuler, Charles F, Derynck, Rik, Werb, Zena
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Animals, Newborn Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Classical genetics, quantitative genetics, hybrids Cleft Palate - genetics Cleft Palate - pathology Craniofacial Abnormalities - genetics Craniofacial Abnormalities - pathology Culture Techniques Female Fundamental and applied biological sciences. Psychology Gelatinases - drug effects Gelatinases - secretion Gene Function Genetics of eukaryotes. Biological and molecular evolution Human Genetics letter Mandible - drug effects Mandible - embryology Mandible - growth & development Maxillofacial Development - physiology Metalloendopeptidases - drug effects Metalloendopeptidases - secretion Mice Mutation Palate - embryology Palate - growth & development Pregnancy Protease Inhibitors - pharmacology Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - physiology Skull - embryology Skull - growth & development Vertebrata
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