Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes)
This study compared the effect of standard topical antibiotic management versus a biological skin substitute wound closure for mid-partial thickness burns of the face. Adult patients with mid-dermal facial burns produced by flash flames or flame exposure were studied using a randomized prospective s...
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| Veröffentlicht in: | Burns 1999-05, Vol.25 (3), p.256-261 |
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| creator | Demling, Robert H DeSanti, Leslie |
| description | This study compared the effect of standard topical antibiotic management versus a biological skin substitute wound closure for mid-partial thickness burns of the face. Adult patients with mid-dermal facial burns produced by flash flames or flame exposure were studied using a randomized prospective study design. Total daily burn care time, pain (0–10 scale) and healing time were monitored. Immediately after partial thickness debridement, the entire face burn, including ears, was closed with a bioengineered skin substitute coated with fibronectin (TransCyte) or treated by the open technique using bacitracin ointment applied 2–3 times daily. 21 patients were studied, with 10 patients in the skin substitute group. We found a significant decrease in wound care time 0.35±0.1 versus 1.9±0.5 h, decrease in pain of 2±1 versus 4±2 and re-epithelialization time 7±2 versus 13±4 days in the skin substitute group compared to topical antibiotics. We can conclude that a bioengineered skin substitute significantly improves the management and healing rate of partial thickness facial burns, compared to the standard open topical ointment technique. |
| doi_str_mv | 10.1016/S0305-4179(98)00165-X |
| format | Article |
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Adult patients with mid-dermal facial burns produced by flash flames or flame exposure were studied using a randomized prospective study design. Total daily burn care time, pain (0–10 scale) and healing time were monitored. Immediately after partial thickness debridement, the entire face burn, including ears, was closed with a bioengineered skin substitute coated with fibronectin (TransCyte) or treated by the open technique using bacitracin ointment applied 2–3 times daily. 21 patients were studied, with 10 patients in the skin substitute group. We found a significant decrease in wound care time 0.35±0.1 versus 1.9±0.5 h, decrease in pain of 2±1 versus 4±2 and re-epithelialization time 7±2 versus 13±4 days in the skin substitute group compared to topical antibiotics. We can conclude that a bioengineered skin substitute significantly improves the management and healing rate of partial thickness facial burns, compared to the standard open topical ointment technique.</description><identifier>ISSN: 0305-4179</identifier><identifier>EISSN: 1879-1409</identifier><identifier>DOI: 10.1016/S0305-4179(98)00165-X</identifier><identifier>PMID: 10323611</identifier><identifier>CODEN: BURND8</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Topical ; Adult ; Anti-Infective Agents, Local - administration & dosage ; Bacitracin - administration & dosage ; Biocompatible Materials - therapeutic use ; Bioengineered skin substitute ; Biological and medical sciences ; Burns - drug therapy ; Burns - pathology ; Burns - surgery ; Diseases of the skin. Cosmetics ; Face ; Facial Injuries - drug therapy ; Facial Injuries - surgery ; Female ; Graft Survival ; Humans ; Injury Severity Score ; Male ; Medical sciences ; Partial thickness burn ; Prospective Studies ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Skin Transplantation - methods ; Skin, Artificial ; Treatment Outcome ; Wound Healing</subject><ispartof>Burns, 1999-05, Vol.25 (3), p.256-261</ispartof><rights>1999 Elsevier Science Ltd</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-57a6281e0e1091ec7f4c2472f348e5e363dd02d1f59de684ed65986e9e7201b83</citedby><cites>FETCH-LOGICAL-c485t-57a6281e0e1091ec7f4c2472f348e5e363dd02d1f59de684ed65986e9e7201b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030541799800165X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1762207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10323611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Demling, Robert H</creatorcontrib><creatorcontrib>DeSanti, Leslie</creatorcontrib><title>Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes)</title><title>Burns</title><addtitle>Burns</addtitle><description>This study compared the effect of standard topical antibiotic management versus a biological skin substitute wound closure for mid-partial thickness burns of the face. Adult patients with mid-dermal facial burns produced by flash flames or flame exposure were studied using a randomized prospective study design. Total daily burn care time, pain (0–10 scale) and healing time were monitored. Immediately after partial thickness debridement, the entire face burn, including ears, was closed with a bioengineered skin substitute coated with fibronectin (TransCyte) or treated by the open technique using bacitracin ointment applied 2–3 times daily. 21 patients were studied, with 10 patients in the skin substitute group. We found a significant decrease in wound care time 0.35±0.1 versus 1.9±0.5 h, decrease in pain of 2±1 versus 4±2 and re-epithelialization time 7±2 versus 13±4 days in the skin substitute group compared to topical antibiotics. We can conclude that a bioengineered skin substitute significantly improves the management and healing rate of partial thickness facial burns, compared to the standard open topical ointment technique.</description><subject>Administration, Topical</subject><subject>Adult</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Bacitracin - administration & dosage</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Bioengineered skin substitute</subject><subject>Biological and medical sciences</subject><subject>Burns - drug therapy</subject><subject>Burns - pathology</subject><subject>Burns - surgery</subject><subject>Diseases of the skin. Cosmetics</subject><subject>Face</subject><subject>Facial Injuries - drug therapy</subject><subject>Facial Injuries - surgery</subject><subject>Female</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Partial thickness burn</subject><subject>Prospective Studies</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Skin Transplantation - methods</subject><subject>Skin, Artificial</subject><subject>Treatment Outcome</subject><subject>Wound Healing</subject><issn>0305-4179</issn><issn>1879-1409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq2qiC6Fn1CUQ4XaQ8BO4q9TVVV8SUUcAKk3y7EnrenG3nocJP493u6qcMMXj14_M2M9hJww-pZRJt59oz3l7cCkPtPqnNaItzcHZMWU1C0bqD4kqyfkiLxA_Enr4Yo-J0eM9l0vGFuR8sVGewszxNKkqdnYXIJdN-UuuPsIiM1k3TYYlxyxOXNprkjAFLd0SZvg6qONJYwhleCw1r6pdQvxNkSADL7B-xAbXEYsoSwF8PwleTbZNcKr_X1Mfnx4__3qU3v99ePnq8vr1g2Kl5ZLKzrFgAKjmoGT0-C6QXZTPyjg0Ivee9p5NnHtQagBvOBaCdAgO8pG1R-TN7u5m5weFsBi5oAO1msbIS1ohJYDr6oqyHegywkxw2Q2Ocw2_zaMmq1u86jbbF0arcyjbnNT-17vFyzjDP6frp3fCpzuAYvV1JRtdAH_clJ0HZUVu9hhUG38CpANugDRgQ8ZXDE-hf_85A9RPp3E</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>Demling, Robert H</creator><creator>DeSanti, Leslie</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990501</creationdate><title>Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes)</title><author>Demling, Robert H ; DeSanti, Leslie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-57a6281e0e1091ec7f4c2472f348e5e363dd02d1f59de684ed65986e9e7201b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Administration, Topical</topic><topic>Adult</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Bacitracin - administration & dosage</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Bioengineered skin substitute</topic><topic>Biological and medical sciences</topic><topic>Burns - drug therapy</topic><topic>Burns - pathology</topic><topic>Burns - surgery</topic><topic>Diseases of the skin. Cosmetics</topic><topic>Face</topic><topic>Facial Injuries - drug therapy</topic><topic>Facial Injuries - surgery</topic><topic>Female</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Partial thickness burn</topic><topic>Prospective Studies</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Skin Transplantation - methods</topic><topic>Skin, Artificial</topic><topic>Treatment Outcome</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Demling, Robert H</creatorcontrib><creatorcontrib>DeSanti, Leslie</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Burns</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Demling, Robert H</au><au>DeSanti, Leslie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes)</atitle><jtitle>Burns</jtitle><addtitle>Burns</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>25</volume><issue>3</issue><spage>256</spage><epage>261</epage><pages>256-261</pages><issn>0305-4179</issn><eissn>1879-1409</eissn><coden>BURND8</coden><abstract>This study compared the effect of standard topical antibiotic management versus a biological skin substitute wound closure for mid-partial thickness burns of the face. Adult patients with mid-dermal facial burns produced by flash flames or flame exposure were studied using a randomized prospective study design. Total daily burn care time, pain (0–10 scale) and healing time were monitored. Immediately after partial thickness debridement, the entire face burn, including ears, was closed with a bioengineered skin substitute coated with fibronectin (TransCyte) or treated by the open technique using bacitracin ointment applied 2–3 times daily. 21 patients were studied, with 10 patients in the skin substitute group. We found a significant decrease in wound care time 0.35±0.1 versus 1.9±0.5 h, decrease in pain of 2±1 versus 4±2 and re-epithelialization time 7±2 versus 13±4 days in the skin substitute group compared to topical antibiotics. We can conclude that a bioengineered skin substitute significantly improves the management and healing rate of partial thickness facial burns, compared to the standard open topical ointment technique.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>10323611</pmid><doi>10.1016/S0305-4179(98)00165-X</doi><tpages>6</tpages></addata></record> |
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| subjects | Administration, Topical Adult Anti-Infective Agents, Local - administration & dosage Bacitracin - administration & dosage Biocompatible Materials - therapeutic use Bioengineered skin substitute Biological and medical sciences Burns - drug therapy Burns - pathology Burns - surgery Diseases of the skin. Cosmetics Face Facial Injuries - drug therapy Facial Injuries - surgery Female Graft Survival Humans Injury Severity Score Male Medical sciences Partial thickness burn Prospective Studies Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Skin Transplantation - methods Skin, Artificial Treatment Outcome Wound Healing |
| title | Management of partial thickness facial burns (comparison of topical antibiotics and bio-engineered skin substitutes) |
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