Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation

Cre-mediated excision of exon 11 of the breast-tumour suppressor gene Brca1 in mouse mammary epithelial cells causes increased apoptosis and abnormal ductal development. Mammary tumour formation occurs after long latency and is associated with genetic instability characterized by aneuploidy, chromos...

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Veröffentlicht in:	Nature genetics 1999-05, Vol.22 (1), p.37-43
Hauptverfasser:	Deng, Chu-Xia, Xu, Xiaoling, Wagner, Kay-Uwe, Larson, Denise, Weaver, Zoë, Li, Cuiling, Ried, Thomas, Hennighausen, Lothar, Wynshaw-Boris, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Alleles Animal Genetics and Genomics Animals Apoptosis - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine BRCA1 Protein - genetics Cancer Research Cell Line Epithelial Cells - metabolism Epithelial Cells - pathology Female Gene Function Genes, p53 - genetics Gynecology. Andrology. Obstetrics Human Genetics Mammary gland diseases Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Animal - pathology Mammary Neoplasms, Animal - genetics Mammary Neoplasms, Animal - pathology Medical sciences Mice Mice, Inbred Strains Mutation Translocation, Genetic Tumors
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