Solid‐state chemical stability of proteins and peptides

Peptide and protein drugs are often formulated in the solid‐state to provide stabilization during storage. However, reactions can occur in the solid‐state, leading to degradation and inactivation of these agents. This review summarizes the major chemical reactions affecting proteins and peptides in...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1999-05, Vol.88 (5), p.489-500
Hauptverfasser:	Lai, M.C., Topp, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences General pharmacology Hydrogen-Ion Concentration Medical sciences Oxidation-Reduction Peptides - chemistry Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Proteins - chemistry Temperature
Online-Zugang:	Volltext
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