(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population
Alleles of the CAG and the GGC repeat in the first exon of the human androgen receptor (AR) gene have been shown to be associated with the risk of (advanced) prostate cancer. These studies had been carried out in the United States. We have analysed these polymorphisms in a French–German collection o...
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| Veröffentlicht in: | European journal of human genetics : EJHG 1999-04, Vol.7 (3), p.357-362 |
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| creator | Correa-Cerro, Lina Wöhr, Gudrun Häussler, Jürgen Berthon, Philippe Drelon, Eric Mangin, Philippe Fournier, Georges Cussenot, Oliver Kraus, Petra Just, Walter Paiss, Thomas Cantú, José María Vogel, Walther |
| description | Alleles of the CAG and the GGC repeat in the first exon of the human androgen receptor (AR) gene have been shown to be associated with the risk of (advanced) prostate cancer. These studies had been carried out in the United States. We have analysed these polymorphisms in a French–German collection of 105 controls, 132 sporadic cases, and a sample of prostate cancer families comprising 85 affected and 46 not affected family members. The allele distributions were very similar in all four groups and chi square statistics on contingency tables did not detect any significant differences. The relative risk (odds ratio, OR) were calculated using logistic regression and did not reach significance despite sufficient numbers of patients and controls. Typical results were OR = 1.007; 95% Confidence Interval (CI) 0.97–1.1,
P
= 0.87 for CAG as continuous variable and OR = 1.2 (95% CI 0.7–2.0),
P
= 0.47 for CAG classes < 22 and > = 22 repeats. Similar results were obtained for subgroups defined by age or Gleason score. We conclude that these polymorphisms can not be used as predictive parameters for prostate cancer in the French or German population. |
| doi_str_mv | 10.1038/sj.ejhg.5200298 |
| format | Article |
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P
= 0.87 for CAG as continuous variable and OR = 1.2 (95% CI 0.7–2.0),
P
= 0.47 for CAG classes < 22 and > = 22 repeats. Similar results were obtained for subgroups defined by age or Gleason score. We conclude that these polymorphisms can not be used as predictive parameters for prostate cancer in the French or German population.</description><identifier>ISSN: 1018-4813</identifier><identifier>EISSN: 1476-5438</identifier><identifier>DOI: 10.1038/sj.ejhg.5200298</identifier><identifier>PMID: 10234512</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Aged, 80 and over ; Alleles ; Bioinformatics ; Biomedical and Life Sciences ; Biomedicine ; Cytogenetics ; France ; Gene Expression ; Germany ; Human Genetics ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms - genetics ; Receptors, Androgen - genetics ; Trinucleotide Repeats</subject><ispartof>European journal of human genetics : EJHG, 1999-04, Vol.7 (3), p.357-362</ispartof><rights>Macmillan Publishers Limited 1999</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-d456b7aec54899c7a6c6089b6f07561cd7eb695c259f7733262b975ebcd5fc5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejhg.5200298$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejhg.5200298$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10234512$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Correa-Cerro, Lina</creatorcontrib><creatorcontrib>Wöhr, Gudrun</creatorcontrib><creatorcontrib>Häussler, Jürgen</creatorcontrib><creatorcontrib>Berthon, Philippe</creatorcontrib><creatorcontrib>Drelon, Eric</creatorcontrib><creatorcontrib>Mangin, Philippe</creatorcontrib><creatorcontrib>Fournier, Georges</creatorcontrib><creatorcontrib>Cussenot, Oliver</creatorcontrib><creatorcontrib>Kraus, Petra</creatorcontrib><creatorcontrib>Just, Walter</creatorcontrib><creatorcontrib>Paiss, Thomas</creatorcontrib><creatorcontrib>Cantú, José María</creatorcontrib><creatorcontrib>Vogel, Walther</creatorcontrib><title>(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population</title><title>European journal of human genetics : EJHG</title><addtitle>Eur J Hum Genet</addtitle><addtitle>Eur J Hum Genet</addtitle><description>Alleles of the CAG and the GGC repeat in the first exon of the human androgen receptor (AR) gene have been shown to be associated with the risk of (advanced) prostate cancer. These studies had been carried out in the United States. We have analysed these polymorphisms in a French–German collection of 105 controls, 132 sporadic cases, and a sample of prostate cancer families comprising 85 affected and 46 not affected family members. The allele distributions were very similar in all four groups and chi square statistics on contingency tables did not detect any significant differences. The relative risk (odds ratio, OR) were calculated using logistic regression and did not reach significance despite sufficient numbers of patients and controls. Typical results were OR = 1.007; 95% Confidence Interval (CI) 0.97–1.1,
P
= 0.87 for CAG as continuous variable and OR = 1.2 (95% CI 0.7–2.0),
P
= 0.47 for CAG classes < 22 and > = 22 repeats. Similar results were obtained for subgroups defined by age or Gleason score. We conclude that these polymorphisms can not be used as predictive parameters for prostate cancer in the French or German population.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Bioinformatics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cytogenetics</subject><subject>France</subject><subject>Gene Expression</subject><subject>Germany</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Receptors, Androgen - genetics</subject><subject>Trinucleotide Repeats</subject><issn>1018-4813</issn><issn>1476-5438</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFv3CAYhlHVqkmunbtFTFUy-AK2ATOeTo1bKWqWdEYYfz7bugMHsKJuWfoL8g_zS4J1N2TpBJ_eh0d8L0LfKFlTUlQ3YVzD2O_WLCckl9UHdE5LwTNWFtXHdCe0ysqKFmfoIoSRkBQK-hmdUZIXJaP5Ofp3td3U13a72WBtW1zXv7GHCXQMeLA49oD7-aDtEnq3A5tSA1N0HqcBsPaArYtYh-DMoCO0-GmIPZ68CzGN2GhrwC8ujW89WNO_Pr_U4Bfn5KZ5r-Pg7Bf0qdP7AF9P5wr9uf3xsP2Z3d3Xv7abu8wUUsSsLRlvhAbDykpKIzQ3nFSy4R0RjFPTCmi4ZCZnshOiKHKeN1IwaEzLOsN0sULfj970v8cZQlSHIRjY77UFNwfFpShLwmQCb46gSYsED52a_HDQ_q-iRC3NqzCqpXl1aj69uDyp5-YA7Tv-WHUCyBEIKbI78Gp0s7dp3f863wB4ApIM</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Correa-Cerro, Lina</creator><creator>Wöhr, Gudrun</creator><creator>Häussler, Jürgen</creator><creator>Berthon, Philippe</creator><creator>Drelon, Eric</creator><creator>Mangin, Philippe</creator><creator>Fournier, Georges</creator><creator>Cussenot, Oliver</creator><creator>Kraus, Petra</creator><creator>Just, Walter</creator><creator>Paiss, Thomas</creator><creator>Cantú, José María</creator><creator>Vogel, Walther</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population</title><author>Correa-Cerro, Lina ; Wöhr, Gudrun ; Häussler, Jürgen ; Berthon, Philippe ; Drelon, Eric ; Mangin, Philippe ; Fournier, Georges ; Cussenot, Oliver ; Kraus, Petra ; Just, Walter ; Paiss, Thomas ; Cantú, José María ; Vogel, Walther</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-d456b7aec54899c7a6c6089b6f07561cd7eb695c259f7733262b975ebcd5fc5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Bioinformatics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cytogenetics</topic><topic>France</topic><topic>Gene Expression</topic><topic>Germany</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Receptors, Androgen - genetics</topic><topic>Trinucleotide Repeats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Correa-Cerro, Lina</creatorcontrib><creatorcontrib>Wöhr, Gudrun</creatorcontrib><creatorcontrib>Häussler, Jürgen</creatorcontrib><creatorcontrib>Berthon, Philippe</creatorcontrib><creatorcontrib>Drelon, Eric</creatorcontrib><creatorcontrib>Mangin, Philippe</creatorcontrib><creatorcontrib>Fournier, Georges</creatorcontrib><creatorcontrib>Cussenot, Oliver</creatorcontrib><creatorcontrib>Kraus, Petra</creatorcontrib><creatorcontrib>Just, Walter</creatorcontrib><creatorcontrib>Paiss, Thomas</creatorcontrib><creatorcontrib>Cantú, José María</creatorcontrib><creatorcontrib>Vogel, Walther</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of human genetics : EJHG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Correa-Cerro, Lina</au><au>Wöhr, Gudrun</au><au>Häussler, Jürgen</au><au>Berthon, Philippe</au><au>Drelon, Eric</au><au>Mangin, Philippe</au><au>Fournier, Georges</au><au>Cussenot, Oliver</au><au>Kraus, Petra</au><au>Just, Walter</au><au>Paiss, Thomas</au><au>Cantú, José María</au><au>Vogel, Walther</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>(CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population</atitle><jtitle>European journal of human genetics : EJHG</jtitle><stitle>Eur J Hum Genet</stitle><addtitle>Eur J Hum Genet</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>7</volume><issue>3</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>1018-4813</issn><eissn>1476-5438</eissn><abstract>Alleles of the CAG and the GGC repeat in the first exon of the human androgen receptor (AR) gene have been shown to be associated with the risk of (advanced) prostate cancer. These studies had been carried out in the United States. We have analysed these polymorphisms in a French–German collection of 105 controls, 132 sporadic cases, and a sample of prostate cancer families comprising 85 affected and 46 not affected family members. The allele distributions were very similar in all four groups and chi square statistics on contingency tables did not detect any significant differences. The relative risk (odds ratio, OR) were calculated using logistic regression and did not reach significance despite sufficient numbers of patients and controls. Typical results were OR = 1.007; 95% Confidence Interval (CI) 0.97–1.1,
P
= 0.87 for CAG as continuous variable and OR = 1.2 (95% CI 0.7–2.0),
P
= 0.47 for CAG classes < 22 and > = 22 repeats. Similar results were obtained for subgroups defined by age or Gleason score. We conclude that these polymorphisms can not be used as predictive parameters for prostate cancer in the French or German population.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>10234512</pmid><doi>10.1038/sj.ejhg.5200298</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Aged Aged, 80 and over Alleles Bioinformatics Biomedical and Life Sciences Biomedicine Cytogenetics France Gene Expression Germany Human Genetics Humans Male Middle Aged Prostatic Neoplasms - genetics Receptors, Androgen - genetics Trinucleotide Repeats |
| title | (CAG)nCAA and GGN repeats in the human androgen receptor gene are not associated with prostate cancer in a French–German population |
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