Benzotriazonine as a new core structure for the design of CCK-receptor antagonists
The search for heterocyclic scaffolds for the design of non‐peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4‐N‐benzyl‐2,3,4,5,6,7‐hexahydro‐1H‐1,4,7‐benzotriazonin‐2,6‐dione with a 9‐membered core structure as a new low mass lead compound that exhibits subm...
Gespeichert in:
| Veröffentlicht in: | Journal of peptide science 1999-03, Vol.5 (3), p.155-158 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 158 |
|---|---|
| container_issue | 3 |
| container_start_page | 155 |
| container_title | Journal of peptide science |
| container_volume | 5 |
| creator | Escherich, Achim Escrieut, Chantal Fourmy, Daniel Moroder, Luis |
| description | The search for heterocyclic scaffolds for the design of non‐peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4‐N‐benzyl‐2,3,4,5,6,7‐hexahydro‐1H‐1,4,7‐benzotriazonin‐2,6‐dione with a 9‐membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK‐A receptor with a 54‐fold selectivity over the CCK‐B/gastrin receptor. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/(SICI)1099-1387(199903)5:3<155::AID-PSC195>3.0.CO;2-E |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69743991</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21157128</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4345-2bf8e035c482a58a6995f7f6a179064242efe54cb9f689c830ec06b6ce7ceb983</originalsourceid><addsrcrecordid>eNqFkdtu1DAQQCMEohf4BZQn1D5k8SW24-UilbAtC6VbUdA-jhx3XAK7ydZOVNqvx1FWFRIInjyaGZ8ZzUmS15RMKCHsxcHFvJwfUqJ1RnmhDqjWmvBDMeWvqBDT6dH8XXZ-UVIt3vAJmZSLlyybPUh27388HGIlMiap2kn2QvhOSKwJ-TjZoYQzLoTeTT6_xeau7Xxt7tqmbjA1ITVpgzepbT2mofO97foYudan3TdMLzHUV03aurQsP2YeLW66WDJNZ64iIXThSfLImVXAp9t3P_l6PPtSvs9OFyfz8ug0sznP416VK5BwYfOCGVEYGXdzyklDlSYyZzlDhyK3lXay0LbgBC2RlbSoLFa64PvJ85G78e11j6GDdR0srlamwbYPILXKudb0v42MUqEoG4jbTa1vQ_DoYOPrtfG3QAkMVgAGKzDcGIYbw2gFBHCIVgCiFRitxAyBcgEMZpH7bLtAX63x8jfqqCE2LMeGm3qFt39M_ffQv87cZiI5G8nRDP68Jxv_A6TiSsDy7AQ-FGe8OF9-gmP-C6vXtto</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21157128</pqid></control><display><type>article</type><title>Benzotriazonine as a new core structure for the design of CCK-receptor antagonists</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Escherich, Achim ; Escrieut, Chantal ; Fourmy, Daniel ; Moroder, Luis</creator><creatorcontrib>Escherich, Achim ; Escrieut, Chantal ; Fourmy, Daniel ; Moroder, Luis</creatorcontrib><description>The search for heterocyclic scaffolds for the design of non‐peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4‐N‐benzyl‐2,3,4,5,6,7‐hexahydro‐1H‐1,4,7‐benzotriazonin‐2,6‐dione with a 9‐membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK‐A receptor with a 54‐fold selectivity over the CCK‐B/gastrin receptor. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.</description><identifier>ISSN: 1075-2617</identifier><identifier>EISSN: 1099-1387</identifier><identifier>DOI: 10.1002/(SICI)1099-1387(199903)5:3<155::AID-PSC195>3.0.CO;2-E</identifier><identifier>PMID: 10323559</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; benzotriazonine ; CCK ; CCK-receptor antagonists ; CHO Cells - metabolism ; Chromatography, High Pressure Liquid ; Cricetinae ; Crystallization ; Drug Design ; gastrin ; peptide hormone ; Receptor, Cholecystokinin A ; Receptor, Cholecystokinin B ; Receptors, Cholecystokinin - antagonists & inhibitors ; Receptors, Cholecystokinin - metabolism ; Structure-Activity Relationship ; Triazines - chemical synthesis ; Triazines - chemistry ; Triazines - metabolism</subject><ispartof>Journal of peptide science, 1999-03, Vol.5 (3), p.155-158</ispartof><rights>Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4345-2bf8e035c482a58a6995f7f6a179064242efe54cb9f689c830ec06b6ce7ceb983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291099-1387%28199903%295%3A3%3C155%3A%3AAID-PSC195%3E3.0.CO%3B2-E$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291099-1387%28199903%295%3A3%3C155%3A%3AAID-PSC195%3E3.0.CO%3B2-E$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10323559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Escherich, Achim</creatorcontrib><creatorcontrib>Escrieut, Chantal</creatorcontrib><creatorcontrib>Fourmy, Daniel</creatorcontrib><creatorcontrib>Moroder, Luis</creatorcontrib><title>Benzotriazonine as a new core structure for the design of CCK-receptor antagonists</title><title>Journal of peptide science</title><addtitle>J. Peptide Sci</addtitle><description>The search for heterocyclic scaffolds for the design of non‐peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4‐N‐benzyl‐2,3,4,5,6,7‐hexahydro‐1H‐1,4,7‐benzotriazonin‐2,6‐dione with a 9‐membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK‐A receptor with a 54‐fold selectivity over the CCK‐B/gastrin receptor. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>benzotriazonine</subject><subject>CCK</subject><subject>CCK-receptor antagonists</subject><subject>CHO Cells - metabolism</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cricetinae</subject><subject>Crystallization</subject><subject>Drug Design</subject><subject>gastrin</subject><subject>peptide hormone</subject><subject>Receptor, Cholecystokinin A</subject><subject>Receptor, Cholecystokinin B</subject><subject>Receptors, Cholecystokinin - antagonists & inhibitors</subject><subject>Receptors, Cholecystokinin - metabolism</subject><subject>Structure-Activity Relationship</subject><subject>Triazines - chemical synthesis</subject><subject>Triazines - chemistry</subject><subject>Triazines - metabolism</subject><issn>1075-2617</issn><issn>1099-1387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkdtu1DAQQCMEohf4BZQn1D5k8SW24-UilbAtC6VbUdA-jhx3XAK7ydZOVNqvx1FWFRIInjyaGZ8ZzUmS15RMKCHsxcHFvJwfUqJ1RnmhDqjWmvBDMeWvqBDT6dH8XXZ-UVIt3vAJmZSLlyybPUh27388HGIlMiap2kn2QvhOSKwJ-TjZoYQzLoTeTT6_xeau7Xxt7tqmbjA1ITVpgzepbT2mofO97foYudan3TdMLzHUV03aurQsP2YeLW66WDJNZ64iIXThSfLImVXAp9t3P_l6PPtSvs9OFyfz8ug0sznP416VK5BwYfOCGVEYGXdzyklDlSYyZzlDhyK3lXay0LbgBC2RlbSoLFa64PvJ85G78e11j6GDdR0srlamwbYPILXKudb0v42MUqEoG4jbTa1vQ_DoYOPrtfG3QAkMVgAGKzDcGIYbw2gFBHCIVgCiFRitxAyBcgEMZpH7bLtAX63x8jfqqCE2LMeGm3qFt39M_ffQv87cZiI5G8nRDP68Jxv_A6TiSsDy7AQ-FGe8OF9-gmP-C6vXtto</recordid><startdate>199903</startdate><enddate>199903</enddate><creator>Escherich, Achim</creator><creator>Escrieut, Chantal</creator><creator>Fourmy, Daniel</creator><creator>Moroder, Luis</creator><general>John Wiley & Sons, Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199903</creationdate><title>Benzotriazonine as a new core structure for the design of CCK-receptor antagonists</title><author>Escherich, Achim ; Escrieut, Chantal ; Fourmy, Daniel ; Moroder, Luis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4345-2bf8e035c482a58a6995f7f6a179064242efe54cb9f689c830ec06b6ce7ceb983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>benzotriazonine</topic><topic>CCK</topic><topic>CCK-receptor antagonists</topic><topic>CHO Cells - metabolism</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cricetinae</topic><topic>Crystallization</topic><topic>Drug Design</topic><topic>gastrin</topic><topic>peptide hormone</topic><topic>Receptor, Cholecystokinin A</topic><topic>Receptor, Cholecystokinin B</topic><topic>Receptors, Cholecystokinin - antagonists & inhibitors</topic><topic>Receptors, Cholecystokinin - metabolism</topic><topic>Structure-Activity Relationship</topic><topic>Triazines - chemical synthesis</topic><topic>Triazines - chemistry</topic><topic>Triazines - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Escherich, Achim</creatorcontrib><creatorcontrib>Escrieut, Chantal</creatorcontrib><creatorcontrib>Fourmy, Daniel</creatorcontrib><creatorcontrib>Moroder, Luis</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of peptide science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Escherich, Achim</au><au>Escrieut, Chantal</au><au>Fourmy, Daniel</au><au>Moroder, Luis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzotriazonine as a new core structure for the design of CCK-receptor antagonists</atitle><jtitle>Journal of peptide science</jtitle><addtitle>J. Peptide Sci</addtitle><date>1999-03</date><risdate>1999</risdate><volume>5</volume><issue>3</issue><spage>155</spage><epage>158</epage><pages>155-158</pages><issn>1075-2617</issn><eissn>1099-1387</eissn><abstract>The search for heterocyclic scaffolds for the design of non‐peptidic and highly selective agonists or antagonists of peptide hormone receptors led to 4‐N‐benzyl‐2,3,4,5,6,7‐hexahydro‐1H‐1,4,7‐benzotriazonin‐2,6‐dione with a 9‐membered core structure as a new low mass lead compound that exhibits submicromolar antagonistic activity at the CCK‐A receptor with a 54‐fold selectivity over the CCK‐B/gastrin receptor. Copyright © 1999 European Peptide Society and John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>10323559</pmid><doi>10.1002/(SICI)1099-1387(199903)5:3<155::AID-PSC195>3.0.CO;2-E</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1075-2617 |
| ispartof | Journal of peptide science, 1999-03, Vol.5 (3), p.155-158 |
| issn | 1075-2617 1099-1387 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69743991 |
| source | MEDLINE; Wiley Journals |
| subjects | Animals benzotriazonine CCK CCK-receptor antagonists CHO Cells - metabolism Chromatography, High Pressure Liquid Cricetinae Crystallization Drug Design gastrin peptide hormone Receptor, Cholecystokinin A Receptor, Cholecystokinin B Receptors, Cholecystokinin - antagonists & inhibitors Receptors, Cholecystokinin - metabolism Structure-Activity Relationship Triazines - chemical synthesis Triazines - chemistry Triazines - metabolism |
| title | Benzotriazonine as a new core structure for the design of CCK-receptor antagonists |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T12%3A18%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Benzotriazonine%20as%20a%20new%20core%20structure%20for%20the%20design%20of%20CCK-receptor%20antagonists&rft.jtitle=Journal%20of%20peptide%20science&rft.au=Escherich,%20Achim&rft.date=1999-03&rft.volume=5&rft.issue=3&rft.spage=155&rft.epage=158&rft.pages=155-158&rft.issn=1075-2617&rft.eissn=1099-1387&rft_id=info:doi/10.1002/(SICI)1099-1387(199903)5:3%3C155::AID-PSC195%3E3.0.CO;2-E&rft_dat=%3Cproquest_cross%3E21157128%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21157128&rft_id=info:pmid/10323559&rfr_iscdi=true |