Lymphadenectomy and Ovarian Preservation in Low-Grade Endometrial Stromal Sarcoma
To report the impact on overall survival of lymphadenectomy and ovarian preservation in patients with endometrial stromal sarcoma. Data were extracted from the Surveillance, Epidemiology, and End Results Program from 1988 to 2005. Kaplan-Meier and Cox proportional hazards analyses were used to ident...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 2008-11, Vol.112 (5), p.1102-1108 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Shah, Jay P. Bryant, Christopher S. Kumar, Sanjeev Ali-Fehmi, Rouba Malone, John M. Morris, Robert T. |
| description | To report the impact on overall survival of lymphadenectomy and ovarian preservation in patients with endometrial stromal sarcoma.
Data were extracted from the Surveillance, Epidemiology, and End Results Program from 1988 to 2005. Kaplan-Meier and Cox proportional hazards analyses were used to identify possible predictors for survival.
Nine hundred seventy women were reported with endometrial stromal sarcoma. The 384 women with low-grade endometrial stromal sarcoma had a younger age, earlier stage, and longer survival than the 320 women with high-grade lesions. Among the low-grade endometrial stromal sarcoma patients, the incidence of extrauterine disease was 25%, and lymph node metastasis was 7%. Univariable and multivariable analysis demonstrated lymph node metastasis and ovarian preservation were not significant prognostic factors for survival.
In low-grade endometrial stromal sarcoma, the risk of extrauterine spread and lymph node metastasis merit consideration for surgical staging. Neither lymph node metastasis nor ovarian preservation seems to affect the excellent overall survival of these patients.
II. |
| doi_str_mv | 10.1097/AOG.0b013e31818aa89a |
| format | Article |
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Data were extracted from the Surveillance, Epidemiology, and End Results Program from 1988 to 2005. Kaplan-Meier and Cox proportional hazards analyses were used to identify possible predictors for survival.
Nine hundred seventy women were reported with endometrial stromal sarcoma. The 384 women with low-grade endometrial stromal sarcoma had a younger age, earlier stage, and longer survival than the 320 women with high-grade lesions. Among the low-grade endometrial stromal sarcoma patients, the incidence of extrauterine disease was 25%, and lymph node metastasis was 7%. Univariable and multivariable analysis demonstrated lymph node metastasis and ovarian preservation were not significant prognostic factors for survival.
In low-grade endometrial stromal sarcoma, the risk of extrauterine spread and lymph node metastasis merit consideration for surgical staging. Neither lymph node metastasis nor ovarian preservation seems to affect the excellent overall survival of these patients.
II.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>DOI: 10.1097/AOG.0b013e31818aa89a</identifier><identifier>PMID: 18978112</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Endometrial Neoplasms - pathology ; Endometrial Neoplasms - surgery ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Kaplan-Meier Estimate ; Lymph Node Excision ; Lymphatic Metastasis ; Medical sciences ; Middle Aged ; Retrospective Studies ; Sarcoma, Endometrial Stromal - pathology ; Sarcoma, Endometrial Stromal - surgery ; SEER Program ; Sentinel Lymph Node Biopsy ; Young Adult</subject><ispartof>Obstetrics and gynecology (New York. 1953), 2008-11, Vol.112 (5), p.1102-1108</ispartof><rights>The American College of Obstetricians and Gynecologists</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4260-ce9a6c07c0ab1a2d007401841570ccfc371eeb696ad3b4f2922d02c0d39549da3</citedby><cites>FETCH-LOGICAL-c4260-ce9a6c07c0ab1a2d007401841570ccfc371eeb696ad3b4f2922d02c0d39549da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20825087$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18978112$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shah, Jay P.</creatorcontrib><creatorcontrib>Bryant, Christopher S.</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Ali-Fehmi, Rouba</creatorcontrib><creatorcontrib>Malone, John M.</creatorcontrib><creatorcontrib>Morris, Robert T.</creatorcontrib><title>Lymphadenectomy and Ovarian Preservation in Low-Grade Endometrial Stromal Sarcoma</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>To report the impact on overall survival of lymphadenectomy and ovarian preservation in patients with endometrial stromal sarcoma.
Data were extracted from the Surveillance, Epidemiology, and End Results Program from 1988 to 2005. Kaplan-Meier and Cox proportional hazards analyses were used to identify possible predictors for survival.
Nine hundred seventy women were reported with endometrial stromal sarcoma. The 384 women with low-grade endometrial stromal sarcoma had a younger age, earlier stage, and longer survival than the 320 women with high-grade lesions. Among the low-grade endometrial stromal sarcoma patients, the incidence of extrauterine disease was 25%, and lymph node metastasis was 7%. Univariable and multivariable analysis demonstrated lymph node metastasis and ovarian preservation were not significant prognostic factors for survival.
In low-grade endometrial stromal sarcoma, the risk of extrauterine spread and lymph node metastasis merit consideration for surgical staging. Neither lymph node metastasis nor ovarian preservation seems to affect the excellent overall survival of these patients.
II.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Endometrial Neoplasms - surgery</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><subject>Sarcoma, Endometrial Stromal - pathology</subject><subject>Sarcoma, Endometrial Stromal - surgery</subject><subject>SEER Program</subject><subject>Sentinel Lymph Node Biopsy</subject><subject>Young Adult</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU9r20AQxZeS0rhJv0EouiQ3JbN_rN09hpC4BYNTkkBvy2g1wkolrbsrx_jbZ0NMW3oY3gz85g28YeyMwyUHq6-uV4tLqIFLktxwg2gsfmAzbrQshZQ_j9gMQNhSG6WO2eeUngGAV1Z-YsfcWG04FzP2Y7kfNmtsaCQ_hWFf4NgUqxeMHY7FfaRE8QWnLoxFNxbLsCsXMcPF7diEgaZM9cXDFMPwphh9bk7Zxxb7RF8OesKe7m4fb76Vy9Xi-831svRKVFB6slh50B6w5igaAK2AG8XnGrxvvdScqK5shY2sVSusyIzw0Eg7V7ZBecIu3n03MfzeUprc0CVPfY8jhW1yldVKykpnUL2DPoaUIrVuE7sB495xcG9Ruhyl-z_KvPb14L-tB2r-Lh2yy8D5AcDksW8jjr5LfzgBRszB_HN_F_qJYvrVb3cU3Zqwn9YuPwWqDJYCINvmqcwlQL4CdP2NSA</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Shah, Jay P.</creator><creator>Bryant, Christopher S.</creator><creator>Kumar, Sanjeev</creator><creator>Ali-Fehmi, Rouba</creator><creator>Malone, John M.</creator><creator>Morris, Robert T.</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Lymphadenectomy and Ovarian Preservation in Low-Grade Endometrial Stromal Sarcoma</title><author>Shah, Jay P. ; Bryant, Christopher S. ; Kumar, Sanjeev ; Ali-Fehmi, Rouba ; Malone, John M. ; Morris, Robert T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4260-ce9a6c07c0ab1a2d007401841570ccfc371eeb696ad3b4f2922d02c0d39549da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Endometrial Neoplasms - surgery</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><topic>Sarcoma, Endometrial Stromal - pathology</topic><topic>Sarcoma, Endometrial Stromal - surgery</topic><topic>SEER Program</topic><topic>Sentinel Lymph Node Biopsy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Jay P.</creatorcontrib><creatorcontrib>Bryant, Christopher S.</creatorcontrib><creatorcontrib>Kumar, Sanjeev</creatorcontrib><creatorcontrib>Ali-Fehmi, Rouba</creatorcontrib><creatorcontrib>Malone, John M.</creatorcontrib><creatorcontrib>Morris, Robert T.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Jay P.</au><au>Bryant, Christopher S.</au><au>Kumar, Sanjeev</au><au>Ali-Fehmi, Rouba</au><au>Malone, John M.</au><au>Morris, Robert T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymphadenectomy and Ovarian Preservation in Low-Grade Endometrial Stromal Sarcoma</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>112</volume><issue>5</issue><spage>1102</spage><epage>1108</epage><pages>1102-1108</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>To report the impact on overall survival of lymphadenectomy and ovarian preservation in patients with endometrial stromal sarcoma.
Data were extracted from the Surveillance, Epidemiology, and End Results Program from 1988 to 2005. Kaplan-Meier and Cox proportional hazards analyses were used to identify possible predictors for survival.
Nine hundred seventy women were reported with endometrial stromal sarcoma. The 384 women with low-grade endometrial stromal sarcoma had a younger age, earlier stage, and longer survival than the 320 women with high-grade lesions. Among the low-grade endometrial stromal sarcoma patients, the incidence of extrauterine disease was 25%, and lymph node metastasis was 7%. Univariable and multivariable analysis demonstrated lymph node metastasis and ovarian preservation were not significant prognostic factors for survival.
In low-grade endometrial stromal sarcoma, the risk of extrauterine spread and lymph node metastasis merit consideration for surgical staging. Neither lymph node metastasis nor ovarian preservation seems to affect the excellent overall survival of these patients.
II.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>18978112</pmid><doi>10.1097/AOG.0b013e31818aa89a</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Endometrial Neoplasms - pathology Endometrial Neoplasms - surgery Female Gynecology. Andrology. Obstetrics Humans Kaplan-Meier Estimate Lymph Node Excision Lymphatic Metastasis Medical sciences Middle Aged Retrospective Studies Sarcoma, Endometrial Stromal - pathology Sarcoma, Endometrial Stromal - surgery SEER Program Sentinel Lymph Node Biopsy Young Adult |
| title | Lymphadenectomy and Ovarian Preservation in Low-Grade Endometrial Stromal Sarcoma |
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