Pharmacological and molecular characterization of ATP-sensitive K + channels in the TE671 human medulloblastoma cell line

ATP-sensitive K + (K ATP) channels in the human medulloblastoma TE671 cell line were characterized by membrane potential assays utilizing a potentiometric fluorescent probe, bis-(1,3-dibutylbarbituric acid)trimethine oxonol (DiBAC 4(3)), and by mRNA analysis. Membrane potential assays showed concent...

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Veröffentlicht in:	European journal of pharmacology 1999-04, Vol.370 (2), p.179-185
Hauptverfasser:	Miller, Thomas R, Taber, Rachel Davis, Molinari, Eduardo J, Whiteaker, Kristi L, Monteggia, Lisa M, Scott, Victoria E.S, Brioni, Jorge D, Sullivan, James P, Gopalakrishnan, Murali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Barbiturates Biological and medical sciences Cells, Cultured Central nervous system Cromakalim - pharmacology Electrophysiology Fluorescent Dyes Fluorometry Fundamental and applied biological sciences. Psychology Glipizide - pharmacology Glyburide Glyburide - pharmacology Humans Insulinoma - chemistry Isoxazoles K + channel, ATP-sensitive K + channel, inward rectifying Medulloblastoma - chemistry Membrane Potentials - drug effects Muscle, Smooth - chemistry Parasympatholytics - pharmacology Potassium Channels - chemistry Potassium Channels - classification Potassium Channels - drug effects Potassium Channels - pharmacology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Sulfonylurea receptor TE671 medulloblastoma cell Tumor Cells, Cultured Vertebrates: nervous system and sense organs
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