Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition
Platycodin D (PD) isolated from Platycodi Radix has been reported to have anti-inflammatory and anti-tumor activities. In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentra...
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| creator | Chung, Ji Won Noh, Eun Jung Zhao, Hai Lin Sim, Joon-Soo Ha, Young Wan Shin, Eun Myoung Lee, Eun Bang Cheong, Choon Sik Kim, Yeong Shik |
| description | Platycodin D (PD) isolated from Platycodi Radix has been reported to have anti-inflammatory and anti-tumor activities. In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentration-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, however, PrsD did not inhibit NO production in LPS-induced macrophages. Furthermore, PrsDMe inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without appreciable cytotoxic effects. In the transfectant RAW 264.7 cells, PrsDMe was observed to reduce the level of nuclear factor-κB (NF-κB) activity. PrsDMe also inhibited the degradation of an inhibitory protein called inhibitor κB (IκB). Therefore, it was suggested that PrsDMe inhibited the expression of LPS-induced iNOS and COX-2 genes by suppressing NF-κB activation at the transcriptional level. Also, PrsDMe showed carrageenan-induced acute anti-inflammatory activity and the adjuvant-induced anti-arthritic activity in mice. In conclusion, we suggest that these compounds exert an anti-inflammatory effect through the regulation of the NF-κB pathway. The different activities of PD, PrsD and PrsDMe are based on the structure of the sugar substituent or methyl group at the C28-carboxyl position. |
| doi_str_mv | 10.1248/bpb.31.2114 |
| format | Article |
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In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentration-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, however, PrsD did not inhibit NO production in LPS-induced macrophages. Furthermore, PrsDMe inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without appreciable cytotoxic effects. In the transfectant RAW 264.7 cells, PrsDMe was observed to reduce the level of nuclear factor-κB (NF-κB) activity. PrsDMe also inhibited the degradation of an inhibitory protein called inhibitor κB (IκB). Therefore, it was suggested that PrsDMe inhibited the expression of LPS-induced iNOS and COX-2 genes by suppressing NF-κB activation at the transcriptional level. Also, PrsDMe showed carrageenan-induced acute anti-inflammatory activity and the adjuvant-induced anti-arthritic activity in mice. In conclusion, we suggest that these compounds exert an anti-inflammatory effect through the regulation of the NF-κB pathway. The different activities of PD, PrsD and PrsDMe are based on the structure of the sugar substituent or methyl group at the C28-carboxyl position.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.2114</identifier><identifier>PMID: 18981583</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>animal model ; Animals ; anti-inflammation ; Anti-Inflammatory Agents, Non-Steroidal - chemistry ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis, Experimental - drug therapy ; Arthritis, Experimental - metabolism ; Blotting, Western ; Cyclooxygenase 2 - biosynthesis ; Dinoprostone - biosynthesis ; Edema - drug therapy ; Edema - metabolism ; Electrophoretic Mobility Shift Assay ; Genes, Reporter ; Lipopolysaccharides - pharmacology ; Male ; Mice ; Mice, Inbred ICR ; Molecular Structure ; NF-kappa B - antagonists & inhibitors ; NF-kappa B - genetics ; Nitric Oxide - biosynthesis ; Nitric Oxide Synthase Type II - biosynthesis ; nuclear factor-κB ; platycodin D ; Platycodon - chemistry ; prosapogenin methyl ester ; Reverse Transcriptase Polymerase Chain Reaction ; Saponins - chemistry ; Saponins - pharmacology ; Saponins - therapeutic use ; Transfection ; Triterpenes - chemistry ; Triterpenes - pharmacology ; Triterpenes - therapeutic use</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/11/01, Vol.31(11), pp.2114-2120</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c690t-fa375d465e46db7ba2dd01adcb43672d3b43c38610f7a150d7beca7e1ae0eef33</citedby><cites>FETCH-LOGICAL-c690t-fa375d465e46db7ba2dd01adcb43672d3b43c38610f7a150d7beca7e1ae0eef33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18981583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Ji Won</creatorcontrib><creatorcontrib>Noh, Eun Jung</creatorcontrib><creatorcontrib>Zhao, Hai Lin</creatorcontrib><creatorcontrib>Sim, Joon-Soo</creatorcontrib><creatorcontrib>Ha, Young Wan</creatorcontrib><creatorcontrib>Shin, Eun Myoung</creatorcontrib><creatorcontrib>Lee, Eun Bang</creatorcontrib><creatorcontrib>Cheong, Choon Sik</creatorcontrib><creatorcontrib>Kim, Yeong Shik</creatorcontrib><creatorcontrib>aNatural Products Research Institute College of Pharmacy Seoul National University</creatorcontrib><creatorcontrib>cCollege of Pharmacy Duksung Women's University</creatorcontrib><creatorcontrib>bNational Institute of Agricultural Biotechnology</creatorcontrib><title>Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Platycodin D (PD) isolated from Platycodi Radix has been reported to have anti-inflammatory and anti-tumor activities. In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentration-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, however, PrsD did not inhibit NO production in LPS-induced macrophages. Furthermore, PrsDMe inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without appreciable cytotoxic effects. In the transfectant RAW 264.7 cells, PrsDMe was observed to reduce the level of nuclear factor-κB (NF-κB) activity. PrsDMe also inhibited the degradation of an inhibitory protein called inhibitor κB (IκB). Therefore, it was suggested that PrsDMe inhibited the expression of LPS-induced iNOS and COX-2 genes by suppressing NF-κB activation at the transcriptional level. Also, PrsDMe showed carrageenan-induced acute anti-inflammatory activity and the adjuvant-induced anti-arthritic activity in mice. In conclusion, we suggest that these compounds exert an anti-inflammatory effect through the regulation of the NF-κB pathway. The different activities of PD, PrsD and PrsDMe are based on the structure of the sugar substituent or methyl group at the C28-carboxyl position.</description><subject>animal model</subject><subject>Animals</subject><subject>anti-inflammation</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - chemistry</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Arthritis, Experimental - drug therapy</subject><subject>Arthritis, Experimental - metabolism</subject><subject>Blotting, Western</subject><subject>Cyclooxygenase 2 - biosynthesis</subject><subject>Dinoprostone - biosynthesis</subject><subject>Edema - drug therapy</subject><subject>Edema - metabolism</subject><subject>Electrophoretic Mobility Shift Assay</subject><subject>Genes, Reporter</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Molecular Structure</subject><subject>NF-kappa B - antagonists & inhibitors</subject><subject>NF-kappa B - genetics</subject><subject>Nitric Oxide - biosynthesis</subject><subject>Nitric Oxide Synthase Type II - biosynthesis</subject><subject>nuclear factor-κB</subject><subject>platycodin D</subject><subject>Platycodon - chemistry</subject><subject>prosapogenin methyl ester</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Saponins - chemistry</subject><subject>Saponins - pharmacology</subject><subject>Saponins - therapeutic use</subject><subject>Transfection</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - pharmacology</subject><subject>Triterpenes - therapeutic use</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkc1v1DAQxS0EotvCiTuKhMQFZfFX4uS4LV2oVKAHOFsTx-l6SezUdory39fdbKnExSP5_ebNaB5C7wheE8qrz83YrBlZU0L4C7QijIu8oKR4iVa4JlVekqI6Qach7DHGAlP2Gp2Qqq7SN1uhuLHR5MZ2PQwDROfnbKOiuTdxzlyX3XgXYHS32hqbfddxN_fZZYjaH8Qe4qxcm6Qv2b2B7Mekeg0-24JKTvkfGEc4z24g7v7CnF3ZnWlMNM6-Qa866IN-e6xn6Pf28tfFt_z659eri811rsoax7wDJoqWl4XmZduIBmjbYgKtajgrBW1ZqopVJcGdAFLgVjRagdAENNa6Y-wMfVx8R-_uJh2iHExQuu_BajcFWdaC07qqEvjhP3DvJm_TbpJwXrOyoEIk6tNCqXSV4HUnR28G8LMkWD5GIVMUkhH5GEWi3x89p2bQ7TN7vH0CtguQVKOgd7Y3Vj9PVkE0xvVOUowriTEjhEhM-cE-PRSLuijrIhmdL0b7EOFW_5sEPpoUyNNWqXt5D_1PotqBl9qyB63Is0Y</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Chung, Ji Won</creator><creator>Noh, Eun Jung</creator><creator>Zhao, Hai Lin</creator><creator>Sim, Joon-Soo</creator><creator>Ha, Young Wan</creator><creator>Shin, Eun Myoung</creator><creator>Lee, Eun Bang</creator><creator>Cheong, Choon Sik</creator><creator>Kim, Yeong Shik</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition</title><author>Chung, Ji Won ; Noh, Eun Jung ; Zhao, Hai Lin ; Sim, Joon-Soo ; Ha, Young Wan ; Shin, Eun Myoung ; Lee, Eun Bang ; Cheong, Choon Sik ; Kim, Yeong Shik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c690t-fa375d465e46db7ba2dd01adcb43672d3b43c38610f7a150d7beca7e1ae0eef33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal model</topic><topic>Animals</topic><topic>anti-inflammation</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - chemistry</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Arthritis, Experimental - drug therapy</topic><topic>Arthritis, Experimental - metabolism</topic><topic>Blotting, Western</topic><topic>Cyclooxygenase 2 - biosynthesis</topic><topic>Dinoprostone - biosynthesis</topic><topic>Edema - drug therapy</topic><topic>Edema - metabolism</topic><topic>Electrophoretic Mobility Shift Assay</topic><topic>Genes, Reporter</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Molecular Structure</topic><topic>NF-kappa B - antagonists & inhibitors</topic><topic>NF-kappa B - genetics</topic><topic>Nitric Oxide - biosynthesis</topic><topic>Nitric Oxide Synthase Type II - biosynthesis</topic><topic>nuclear factor-κB</topic><topic>platycodin D</topic><topic>Platycodon - chemistry</topic><topic>prosapogenin methyl ester</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Saponins - chemistry</topic><topic>Saponins - pharmacology</topic><topic>Saponins - therapeutic use</topic><topic>Transfection</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - pharmacology</topic><topic>Triterpenes - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Ji Won</creatorcontrib><creatorcontrib>Noh, Eun Jung</creatorcontrib><creatorcontrib>Zhao, Hai Lin</creatorcontrib><creatorcontrib>Sim, Joon-Soo</creatorcontrib><creatorcontrib>Ha, Young Wan</creatorcontrib><creatorcontrib>Shin, Eun Myoung</creatorcontrib><creatorcontrib>Lee, Eun Bang</creatorcontrib><creatorcontrib>Cheong, Choon Sik</creatorcontrib><creatorcontrib>Kim, Yeong Shik</creatorcontrib><creatorcontrib>aNatural Products Research Institute College of Pharmacy Seoul National University</creatorcontrib><creatorcontrib>cCollege of Pharmacy Duksung Women's University</creatorcontrib><creatorcontrib>bNational Institute of Agricultural Biotechnology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Ji Won</au><au>Noh, Eun Jung</au><au>Zhao, Hai Lin</au><au>Sim, Joon-Soo</au><au>Ha, Young Wan</au><au>Shin, Eun Myoung</au><au>Lee, Eun Bang</au><au>Cheong, Choon Sik</au><au>Kim, Yeong Shik</au><aucorp>aNatural Products Research Institute College of Pharmacy Seoul National University</aucorp><aucorp>cCollege of Pharmacy Duksung Women's University</aucorp><aucorp>bNational Institute of Agricultural Biotechnology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>31</volume><issue>11</issue><spage>2114</spage><epage>2120</epage><pages>2114-2120</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Platycodin D (PD) isolated from Platycodi Radix has been reported to have anti-inflammatory and anti-tumor activities. In this study, we have investigated anti-inflammatory activities of prosapogenin D (PrsD) and prosapogenin D methyl ester (PrsDMe) of PD. The results indicated that PrsDMe concentration-dependently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production, however, PrsD did not inhibit NO production in LPS-induced macrophages. Furthermore, PrsDMe inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) without appreciable cytotoxic effects. In the transfectant RAW 264.7 cells, PrsDMe was observed to reduce the level of nuclear factor-κB (NF-κB) activity. PrsDMe also inhibited the degradation of an inhibitory protein called inhibitor κB (IκB). Therefore, it was suggested that PrsDMe inhibited the expression of LPS-induced iNOS and COX-2 genes by suppressing NF-κB activation at the transcriptional level. Also, PrsDMe showed carrageenan-induced acute anti-inflammatory activity and the adjuvant-induced anti-arthritic activity in mice. In conclusion, we suggest that these compounds exert an anti-inflammatory effect through the regulation of the NF-κB pathway. The different activities of PD, PrsD and PrsDMe are based on the structure of the sugar substituent or methyl group at the C28-carboxyl position.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18981583</pmid><doi>10.1248/bpb.31.2114</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | animal model Animals anti-inflammation Anti-Inflammatory Agents, Non-Steroidal - chemistry Anti-Inflammatory Agents, Non-Steroidal - pharmacology Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Blotting, Western Cyclooxygenase 2 - biosynthesis Dinoprostone - biosynthesis Edema - drug therapy Edema - metabolism Electrophoretic Mobility Shift Assay Genes, Reporter Lipopolysaccharides - pharmacology Male Mice Mice, Inbred ICR Molecular Structure NF-kappa B - antagonists & inhibitors NF-kappa B - genetics Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - biosynthesis nuclear factor-κB platycodin D Platycodon - chemistry prosapogenin methyl ester Reverse Transcriptase Polymerase Chain Reaction Saponins - chemistry Saponins - pharmacology Saponins - therapeutic use Transfection Triterpenes - chemistry Triterpenes - pharmacology Triterpenes - therapeutic use |
| title | Anti-inflammatory Activity of Prosapogenin Methyl Ester of Platycodin D via Nuclear Factor-kappaB Pathway Inhibition |
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