IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

The covalent attachment of ubiquitin to target proteins influences various cellular processes, including DNA repair, NF-kappaB signalling and cell survival. The most common mode of regulation by ubiquitin-conjugation involves specialized ubiquitin-binding proteins that bind to ubiquitylated proteins...

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Veröffentlicht in:	Nature cell biology 2008-11, Vol.10 (11), p.1309-1317
Hauptverfasser:	Gyrd-Hansen, Mads, Darding, Maurice, Miasari, Maria, Santoro, Massimo M, Zender, Lars, Xue, Wen, Tenev, Tencho, da Fonseca, Paula C A, Zvelebil, Marketa, Bujnicki, Janusz M, Lowe, Scott, Silke, John, Meier, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Carcinoma - genetics Carcinoma - pathology Cell Line Cell Survival - genetics Genes, Reporter Glutathione Transferase - metabolism Humans Inhibitor of Apoptosis Proteins - chemistry Inhibitor of Apoptosis Proteins - genetics Inhibitor of Apoptosis Proteins - metabolism Kidney - cytology Liver Neoplasms - genetics Liver Neoplasms - pathology Luciferases - metabolism Neoplasms - genetics Neoplasms - pathology NF-kappa B - antagonists & inhibitors NF-kappa B - genetics NF-kappa B - metabolism Plasmids Protein Binding Protein Structure, Tertiary - genetics Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Transfection Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Ubiquitin - genetics Ubiquitin - metabolism
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