Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease

The genomic region encompassing the Major Histocompatibility Complex (MHC) contains polymorphic frozen blocks which have developed by local imperfect sequential duplication associated with insertion and deletion (indels), In the alpha block surrounding HLA-A, there are ten duplication units or beads...

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Veröffentlicht in:	Immunological reviews 1999-02, Vol.167 (1), p.275-304
Hauptverfasser:	Dawkins, Roger, Leelayuwat, Chanvit, Gaudieri, Silvana, Tay, Guan, Hui, Jennie, Cattley, Sonia, Martinez, Patricia, Kulski, Jerzy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Disease Susceptibility - immunology Disease Susceptibility - virology Gene Duplication Haplotypes - immunology Humans Major Histocompatibility Complex - genetics Major Histocompatibility Complex - immunology Molecular Sequence Data Retroviridae - genetics Retroviridae - immunology
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