Analgesic triterpenes from Sebastiania schottiana roots
The present study was conducted in order to isolate and identify the phytochemical constituents responsible for analgesic effects shown by a methanolic extract obtained from Sebastiania schottiana roots. Conventional chromatographic procedures led to the isolation of moretenone, glutinol, β-sitoster...
Gespeichert in:
| Veröffentlicht in: | Phytomedicine (Stuttgart) 1999-03, Vol.6 (1), p.41-44 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 44 |
|---|---|
| container_issue | 1 |
| container_start_page | 41 |
| container_title | Phytomedicine (Stuttgart) |
| container_volume | 6 |
| creator | Gaertner, M. Müller, L. Roos, J.F. Cani, G. Santos, A.R.S. Niero, R. Calixto, J.B. Yunes, R.A. Delle Monache, F. Cechinel-Filho, V. |
| description | The present study was conducted in order to isolate and identify the phytochemical constituents responsible for analgesic effects shown by a methanolic extract obtained from
Sebastiania schottiana roots. Conventional chromatographic procedures led to the isolation of moretenone, glutinol, β-sitosterol and stigmasterol. The structural elucidation of these compounds was done on the basis of spectral data (IR,
1H- and
13C-NMR) and comparison with authentic samples. Either glutinol or moretenone exhibited marked analgesic action against acetic acid induced abdominal constrictions in mice by intraperitoneal route, indicating 16 to 26-fold higher efficacy than aspirin and paracetamol. When analyzed in a formalin test, both compounds and standard drugs inhibited only the second phase (inflammatory pain). Our results suggest that the roots of
S. schottiana contain analgesic compounds which justify, at least partially, the popular use of this plant for the treatment of urinary problems. |
| doi_str_mv | 10.1016/S0944-7113(99)80033-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69739921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0944711399800336</els_id><sourcerecordid>69739921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-20c99ad0c52a22daa849deada0183674161c6054334daaf8c3cf3961f415953f3</originalsourceid><addsrcrecordid>eNqFkM1LwzAUwIMobk7_BKUn0UM1r0nT5iRj-AUDD1PwFrL0VSNtM5NM8L-3W4d48_QevN_7-hFyCvQKKIjrBZWcpwUAu5DysqSUsVTskTEIKFMq89d9Mv5FRuQohA9KgcuCHpIR0CwrBdAxKaadbt4wWJNEbyP6FXYYktq7NlngUododWd1Esy7i5tcJ965GI7JQa2bgCe7OCEvd7fPs4d0_nT_OJvOU8MExDSjRkpdUZNnOssqrUsuK9SVplAyUfD-WiNozhnjfbEuDTM1kwJqDrnMWc0m5HyYu_Luc40hqtYGg02jO3TroIQsmJQZ9GA-gMa7EDzWauVtq_23Aqo2xtTWmNroUFKqrTEl-r6z3YL1ssXqT9egqAduBgD7N78sehWMxc5gZT2aqCpn_1nxA4hbepM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69739921</pqid></control><display><type>article</type><title>Analgesic triterpenes from Sebastiania schottiana roots</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gaertner, M. ; Müller, L. ; Roos, J.F. ; Cani, G. ; Santos, A.R.S. ; Niero, R. ; Calixto, J.B. ; Yunes, R.A. ; Delle Monache, F. ; Cechinel-Filho, V.</creator><creatorcontrib>Gaertner, M. ; Müller, L. ; Roos, J.F. ; Cani, G. ; Santos, A.R.S. ; Niero, R. ; Calixto, J.B. ; Yunes, R.A. ; Delle Monache, F. ; Cechinel-Filho, V.</creatorcontrib><description>The present study was conducted in order to isolate and identify the phytochemical constituents responsible for analgesic effects shown by a methanolic extract obtained from
Sebastiania schottiana roots. Conventional chromatographic procedures led to the isolation of moretenone, glutinol, β-sitosterol and stigmasterol. The structural elucidation of these compounds was done on the basis of spectral data (IR,
1H- and
13C-NMR) and comparison with authentic samples. Either glutinol or moretenone exhibited marked analgesic action against acetic acid induced abdominal constrictions in mice by intraperitoneal route, indicating 16 to 26-fold higher efficacy than aspirin and paracetamol. When analyzed in a formalin test, both compounds and standard drugs inhibited only the second phase (inflammatory pain). Our results suggest that the roots of
S. schottiana contain analgesic compounds which justify, at least partially, the popular use of this plant for the treatment of urinary problems.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/S0944-7113(99)80033-6</identifier><identifier>PMID: 10228610</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Acetates ; analgesia ; Analgesics, Non-Narcotic - chemistry ; Analgesics, Non-Narcotic - isolation & purification ; Analgesics, Non-Narcotic - pharmacology ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Brazil ; Euphorbiaceae - chemistry ; Formaldehyde ; formalin test ; Indomethacin - pharmacology ; Male ; medicinal plant ; Mice ; Pain Measurement - drug effects ; Plant Roots - chemistry ; Sebastiania schottiana ; triterpenes ; Triterpenes - chemistry ; Triterpenes - isolation & purification ; Triterpenes - pharmacology ; Writhing test</subject><ispartof>Phytomedicine (Stuttgart), 1999-03, Vol.6 (1), p.41-44</ispartof><rights>1999 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-20c99ad0c52a22daa849deada0183674161c6054334daaf8c3cf3961f415953f3</citedby><cites>FETCH-LOGICAL-c361t-20c99ad0c52a22daa849deada0183674161c6054334daaf8c3cf3961f415953f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711399800336$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10228610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaertner, M.</creatorcontrib><creatorcontrib>Müller, L.</creatorcontrib><creatorcontrib>Roos, J.F.</creatorcontrib><creatorcontrib>Cani, G.</creatorcontrib><creatorcontrib>Santos, A.R.S.</creatorcontrib><creatorcontrib>Niero, R.</creatorcontrib><creatorcontrib>Calixto, J.B.</creatorcontrib><creatorcontrib>Yunes, R.A.</creatorcontrib><creatorcontrib>Delle Monache, F.</creatorcontrib><creatorcontrib>Cechinel-Filho, V.</creatorcontrib><title>Analgesic triterpenes from Sebastiania schottiana roots</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>The present study was conducted in order to isolate and identify the phytochemical constituents responsible for analgesic effects shown by a methanolic extract obtained from
Sebastiania schottiana roots. Conventional chromatographic procedures led to the isolation of moretenone, glutinol, β-sitosterol and stigmasterol. The structural elucidation of these compounds was done on the basis of spectral data (IR,
1H- and
13C-NMR) and comparison with authentic samples. Either glutinol or moretenone exhibited marked analgesic action against acetic acid induced abdominal constrictions in mice by intraperitoneal route, indicating 16 to 26-fold higher efficacy than aspirin and paracetamol. When analyzed in a formalin test, both compounds and standard drugs inhibited only the second phase (inflammatory pain). Our results suggest that the roots of
S. schottiana contain analgesic compounds which justify, at least partially, the popular use of this plant for the treatment of urinary problems.</description><subject>Acetates</subject><subject>analgesia</subject><subject>Analgesics, Non-Narcotic - chemistry</subject><subject>Analgesics, Non-Narcotic - isolation & purification</subject><subject>Analgesics, Non-Narcotic - pharmacology</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</subject><subject>Brazil</subject><subject>Euphorbiaceae - chemistry</subject><subject>Formaldehyde</subject><subject>formalin test</subject><subject>Indomethacin - pharmacology</subject><subject>Male</subject><subject>medicinal plant</subject><subject>Mice</subject><subject>Pain Measurement - drug effects</subject><subject>Plant Roots - chemistry</subject><subject>Sebastiania schottiana</subject><subject>triterpenes</subject><subject>Triterpenes - chemistry</subject><subject>Triterpenes - isolation & purification</subject><subject>Triterpenes - pharmacology</subject><subject>Writhing test</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1LwzAUwIMobk7_BKUn0UM1r0nT5iRj-AUDD1PwFrL0VSNtM5NM8L-3W4d48_QevN_7-hFyCvQKKIjrBZWcpwUAu5DysqSUsVTskTEIKFMq89d9Mv5FRuQohA9KgcuCHpIR0CwrBdAxKaadbt4wWJNEbyP6FXYYktq7NlngUododWd1Esy7i5tcJ965GI7JQa2bgCe7OCEvd7fPs4d0_nT_OJvOU8MExDSjRkpdUZNnOssqrUsuK9SVplAyUfD-WiNozhnjfbEuDTM1kwJqDrnMWc0m5HyYu_Luc40hqtYGg02jO3TroIQsmJQZ9GA-gMa7EDzWauVtq_23Aqo2xtTWmNroUFKqrTEl-r6z3YL1ssXqT9egqAduBgD7N78sehWMxc5gZT2aqCpn_1nxA4hbepM</recordid><startdate>19990301</startdate><enddate>19990301</enddate><creator>Gaertner, M.</creator><creator>Müller, L.</creator><creator>Roos, J.F.</creator><creator>Cani, G.</creator><creator>Santos, A.R.S.</creator><creator>Niero, R.</creator><creator>Calixto, J.B.</creator><creator>Yunes, R.A.</creator><creator>Delle Monache, F.</creator><creator>Cechinel-Filho, V.</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990301</creationdate><title>Analgesic triterpenes from Sebastiania schottiana roots</title><author>Gaertner, M. ; Müller, L. ; Roos, J.F. ; Cani, G. ; Santos, A.R.S. ; Niero, R. ; Calixto, J.B. ; Yunes, R.A. ; Delle Monache, F. ; Cechinel-Filho, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-20c99ad0c52a22daa849deada0183674161c6054334daaf8c3cf3961f415953f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acetates</topic><topic>analgesia</topic><topic>Analgesics, Non-Narcotic - chemistry</topic><topic>Analgesics, Non-Narcotic - isolation & purification</topic><topic>Analgesics, Non-Narcotic - pharmacology</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacology</topic><topic>Brazil</topic><topic>Euphorbiaceae - chemistry</topic><topic>Formaldehyde</topic><topic>formalin test</topic><topic>Indomethacin - pharmacology</topic><topic>Male</topic><topic>medicinal plant</topic><topic>Mice</topic><topic>Pain Measurement - drug effects</topic><topic>Plant Roots - chemistry</topic><topic>Sebastiania schottiana</topic><topic>triterpenes</topic><topic>Triterpenes - chemistry</topic><topic>Triterpenes - isolation & purification</topic><topic>Triterpenes - pharmacology</topic><topic>Writhing test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaertner, M.</creatorcontrib><creatorcontrib>Müller, L.</creatorcontrib><creatorcontrib>Roos, J.F.</creatorcontrib><creatorcontrib>Cani, G.</creatorcontrib><creatorcontrib>Santos, A.R.S.</creatorcontrib><creatorcontrib>Niero, R.</creatorcontrib><creatorcontrib>Calixto, J.B.</creatorcontrib><creatorcontrib>Yunes, R.A.</creatorcontrib><creatorcontrib>Delle Monache, F.</creatorcontrib><creatorcontrib>Cechinel-Filho, V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaertner, M.</au><au>Müller, L.</au><au>Roos, J.F.</au><au>Cani, G.</au><au>Santos, A.R.S.</au><au>Niero, R.</au><au>Calixto, J.B.</au><au>Yunes, R.A.</au><au>Delle Monache, F.</au><au>Cechinel-Filho, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analgesic triterpenes from Sebastiania schottiana roots</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>6</volume><issue>1</issue><spage>41</spage><epage>44</epage><pages>41-44</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>The present study was conducted in order to isolate and identify the phytochemical constituents responsible for analgesic effects shown by a methanolic extract obtained from
Sebastiania schottiana roots. Conventional chromatographic procedures led to the isolation of moretenone, glutinol, β-sitosterol and stigmasterol. The structural elucidation of these compounds was done on the basis of spectral data (IR,
1H- and
13C-NMR) and comparison with authentic samples. Either glutinol or moretenone exhibited marked analgesic action against acetic acid induced abdominal constrictions in mice by intraperitoneal route, indicating 16 to 26-fold higher efficacy than aspirin and paracetamol. When analyzed in a formalin test, both compounds and standard drugs inhibited only the second phase (inflammatory pain). Our results suggest that the roots of
S. schottiana contain analgesic compounds which justify, at least partially, the popular use of this plant for the treatment of urinary problems.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>10228610</pmid><doi>10.1016/S0944-7113(99)80033-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 1999-03, Vol.6 (1), p.41-44 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69739921 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetates analgesia Analgesics, Non-Narcotic - chemistry Analgesics, Non-Narcotic - isolation & purification Analgesics, Non-Narcotic - pharmacology Animals Anti-Inflammatory Agents, Non-Steroidal - pharmacology Brazil Euphorbiaceae - chemistry Formaldehyde formalin test Indomethacin - pharmacology Male medicinal plant Mice Pain Measurement - drug effects Plant Roots - chemistry Sebastiania schottiana triterpenes Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology Writhing test |
| title | Analgesic triterpenes from Sebastiania schottiana roots |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A46%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analgesic%20triterpenes%20from%20Sebastiania%20schottiana%20roots&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Gaertner,%20M.&rft.date=1999-03-01&rft.volume=6&rft.issue=1&rft.spage=41&rft.epage=44&rft.pages=41-44&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1016/S0944-7113(99)80033-6&rft_dat=%3Cproquest_cross%3E69739921%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69739921&rft_id=info:pmid/10228610&rft_els_id=S0944711399800336&rfr_iscdi=true |