Cell biology of CML cells
At the cellular level, expansion of haemopoiesis in chronic myeloid leukaemia (CML) must involve some imbalance in cell production along the myeloid maturation pathway. The relevant kinetic parameters are cell loss by apoptosis and differentiation and cell gain by proliferation (self-renewal). In sp...
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| Veröffentlicht in: | Leukemia 1999-04, Vol.13, p.65-71 |
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| container_title | Leukemia |
| container_volume | 13 |
| creator | GORDON, M. Y DAZZI, F MARLEY, S. B LEWIS, J. L NGUYEN, D GRAND, F. H DAVIDSON, R. J GOLDMAN, J. M |
| description | At the cellular level, expansion of haemopoiesis in chronic myeloid leukaemia (CML) must involve some imbalance in cell production along the myeloid maturation pathway. The relevant kinetic parameters are cell loss by apoptosis and differentiation and cell gain by proliferation (self-renewal). In spite of the predominance of the BCR-ABL-positive leukaemic cells, some BCR-ABL-negative, presumably normal, progenitor cells remain for long periods in chronic phase CML. Thus, understanding the kinetics of CML and normal progenitor cells may lead to therapeutic strategies capable of reducing malignant cell growth and reactivating normal haemopoiesis. |
| doi_str_mv | 10.1038/sj.leu.2401281 |
| format | Article |
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Thus, understanding the kinetics of CML and normal progenitor cells may lead to therapeutic strategies capable of reducing malignant cell growth and reactivating normal haemopoiesis.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2401281</identifier><identifier>PMID: 10232368</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Antineoplastic Agents - pharmacology ; Apoptosis ; BCR-ABL protein ; Biological and medical sciences ; Blast Crisis - pathology ; Cell Differentiation ; Cell Division ; Cell proliferation ; Cell self-renewal ; Cells (biology) ; Chronic myeloid leukemia ; Disease Progression ; Drug Design ; Fusion protein ; Fusion Proteins, bcr-abl - physiology ; Hematologic and hematopoietic diseases ; Hematopoiesis ; Hematopoietic Stem Cells - cytology ; Hemopoiesis ; Humans ; Leukemia ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Medical sciences ; Neoplastic Stem Cells - cytology ; Progenitor cells ; Stem cells ; Tumor Cells, Cultured</subject><ispartof>Leukemia, 1999-04, Vol.13, p.65-71</ispartof><rights>1999 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1999.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c340t-cbd87abc0ca0419131fd8b2c4430fa55def8bad06cbc30f9e0724720cc155bea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,23910,23911,25119,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1802531$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10232368$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GORDON, M. Y</creatorcontrib><creatorcontrib>DAZZI, F</creatorcontrib><creatorcontrib>MARLEY, S. B</creatorcontrib><creatorcontrib>LEWIS, J. L</creatorcontrib><creatorcontrib>NGUYEN, D</creatorcontrib><creatorcontrib>GRAND, F. H</creatorcontrib><creatorcontrib>DAVIDSON, R. J</creatorcontrib><creatorcontrib>GOLDMAN, J. M</creatorcontrib><title>Cell biology of CML cells</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>At the cellular level, expansion of haemopoiesis in chronic myeloid leukaemia (CML) must involve some imbalance in cell production along the myeloid maturation pathway. The relevant kinetic parameters are cell loss by apoptosis and differentiation and cell gain by proliferation (self-renewal). In spite of the predominance of the BCR-ABL-positive leukaemic cells, some BCR-ABL-negative, presumably normal, progenitor cells remain for long periods in chronic phase CML. 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Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Neoplastic Stem Cells - cytology</subject><subject>Progenitor cells</subject><subject>Stem cells</subject><subject>Tumor Cells, Cultured</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Lw0AUxBdRbK1eBS8SULylvrffOUrwCyJe9Bx2NxtJSJqabQ79791iRfDi6cG8H8PMEHKOsERg-ja0y85PS8oBqcYDMkeuZCqEwEMyB61VKjPKZ-QkhBZg95THZIZAGWVSz8lF7rsusc3QDR_bZKiT_KVIXNTCKTmqTRf82f4uyPvD_Vv-lBavj8_5XZE6xmGTOltpZawDZ4BjhgzrSlvqOGdQGyEqX2trKpDOuqhkHhTlioJzKIT1hi3Izbfvehw-Jx82Zd-EXQKz8sMUSpkpFnvgvyAqKlHFVRbk6g_YDtO4iiVKKrmIhgqzSF3uqcn2virXY9ObcVv-bBOB6z1ggjNdPZqVa8Ivp4EKhuwLV51v3g</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>GORDON, M. Y</creator><creator>DAZZI, F</creator><creator>MARLEY, S. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; Nature Journals Online |
| subjects | Antineoplastic Agents - pharmacology Apoptosis BCR-ABL protein Biological and medical sciences Blast Crisis - pathology Cell Differentiation Cell Division Cell proliferation Cell self-renewal Cells (biology) Chronic myeloid leukemia Disease Progression Drug Design Fusion protein Fusion Proteins, bcr-abl - physiology Hematologic and hematopoietic diseases Hematopoiesis Hematopoietic Stem Cells - cytology Hemopoiesis Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Neoplastic Stem Cells - cytology Progenitor cells Stem cells Tumor Cells, Cultured |
| title | Cell biology of CML cells |
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