Orchestrating brain-cell renewal: the role of immune cells in adult neurogenesis in health and disease
Immune cells and immune molecules have recently been shown to support neurogenesis from neural stem and progenitor cells in the adult brain. This non-classical immune activity takes place constantly under normal physiological conditions and is extended under acute pathological conditions to include...
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| Veröffentlicht in: | Trends in molecular medicine 2008-11, Vol.14 (11), p.471-478 |
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| container_title | Trends in molecular medicine |
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| creator | Ziv, Yaniv Schwartz, Michal |
| description | Immune cells and immune molecules have recently been shown to support neurogenesis from neural stem and progenitor cells in the adult brain. This non-classical immune activity takes place constantly under normal physiological conditions and is extended under acute pathological conditions to include the attraction of progenitor cells and induction of neurogenesis in regions of the adult central nervous system (CNS) in which formation of new neurons does not normally occur. We suggest that the immune system should be viewed as a novel player in the adult neural stem cell niche and a coordinator of cell renewal processes after injury. We discuss these notions in light of the well-known facts that both immune-cell activity and cell renewal are inherently limited in the adult CNS and that immune and stem cells provide the body’s mechanisms of repair. |
| doi_str_mv | 10.1016/j.molmed.2008.09.004 |
| format | Article |
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| ispartof | Trends in molecular medicine, 2008-11, Vol.14 (11), p.471-478 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Brain - cytology Brain - immunology Brain - physiopathology Brain Diseases - immunology Brain Diseases - physiopathology Brain Diseases - therapy Cell Differentiation Humans Immunity Neurogenesis Pathology Signal Transduction |
| title | Orchestrating brain-cell renewal: the role of immune cells in adult neurogenesis in health and disease |
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