Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb
We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosi...
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| Veröffentlicht in: | Journal of neuropathology and experimental neurology 2008-11, Vol.67 (11), p.1072-1083 |
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| creator | Sengoku, Renpei Saito, Yuko Ikemura, Masako Hatsuta, Hiroyuki Sakiyama, Yoshio Kanemaru, Kazutomi Arai, Tomio Sawabe, Motoji Tanaka, Noriko Mochizuki, Hideki Inoue, Kiyoharu Murayama, Shigeo |
| description | We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, and amyloid β antibodies. LBAS was found in 102 patients (31.9%) in the central nervous system, including the spinal cord; the OB was involved in 85 (26.6%). Among these 85 patients, 2 had LBAS only in the anterior olfactory nucleus, 14 in the peripheral OB only, and 69 in both areas. In 5 patients, Lewy bodies were found only in the OB by hematoxylin and eosin stain; 3 of these patients had Alzheimer disease, and all had LBAS. Very few tyrosine hydroxylase-immunoreactive periglomerular cells exhibited LBAS. All 35 LBAS patients with pigmentation loss in the substantia nigra had LBAS in the OB. LBAS in the amygdala was more strongly correlated with LBAS in the anterior olfactory nucleus than with that in the OB periphery. LBAS did not correlate with systemic tauopathy or amyloid β amyloidosis. These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease. |
| doi_str_mv | 10.1097/NEN.0b013e31818b4126 |
| format | Article |
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Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, and amyloid β antibodies. LBAS was found in 102 patients (31.9%) in the central nervous system, including the spinal cord; the OB was involved in 85 (26.6%). Among these 85 patients, 2 had LBAS only in the anterior olfactory nucleus, 14 in the peripheral OB only, and 69 in both areas. In 5 patients, Lewy bodies were found only in the OB by hematoxylin and eosin stain; 3 of these patients had Alzheimer disease, and all had LBAS. Very few tyrosine hydroxylase-immunoreactive periglomerular cells exhibited LBAS. All 35 LBAS patients with pigmentation loss in the substantia nigra had LBAS in the OB. LBAS in the amygdala was more strongly correlated with LBAS in the anterior olfactory nucleus than with that in the OB periphery. LBAS did not correlate with systemic tauopathy or amyloid β amyloidosis. These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1097/NEN.0b013e31818b4126</identifier><identifier>PMID: 18957894</identifier><identifier>CODEN: JNENAD</identifier><language>eng</language><publisher>Hagerstown, MD: American Association of Neuropathologists, Inc</publisher><subject>Aged ; Aged, 80 and over ; Aging - pathology ; alpha-Synuclein - metabolism ; Amyloid beta-Peptides - metabolism ; Biological and medical sciences ; Brain - metabolism ; Brain - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Humans ; Incidence ; Lewy Bodies - metabolism ; Lewy Bodies - pathology ; Male ; Medical sciences ; Mental Status Schedule ; Neurology ; Olfactory Bulb - metabolism ; Olfactory Bulb - pathology ; Serine - metabolism ; Spinal Cord - metabolism ; Spinal Cord - pathology ; Statistics as Topic ; tau Proteins - metabolism ; Tyrosine 3-Monooxygenase - metabolism ; Ubiquitin - metabolism</subject><ispartof>Journal of neuropathology and experimental neurology, 2008-11, Vol.67 (11), p.1072-1083</ispartof><rights>2008 American Association of Neuropathologists, Inc</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4816-60837f8efcd38d4a7dda7d165901a95ef62d9758f25447e46cd47800c78ee7db3</citedby><cites>FETCH-LOGICAL-c4816-60837f8efcd38d4a7dda7d165901a95ef62d9758f25447e46cd47800c78ee7db3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20904603$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18957894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sengoku, Renpei</creatorcontrib><creatorcontrib>Saito, Yuko</creatorcontrib><creatorcontrib>Ikemura, Masako</creatorcontrib><creatorcontrib>Hatsuta, Hiroyuki</creatorcontrib><creatorcontrib>Sakiyama, Yoshio</creatorcontrib><creatorcontrib>Kanemaru, Kazutomi</creatorcontrib><creatorcontrib>Arai, Tomio</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Tanaka, Noriko</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Inoue, Kiyoharu</creatorcontrib><creatorcontrib>Murayama, Shigeo</creatorcontrib><title>Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb</title><title>Journal of neuropathology and experimental neurology</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, and amyloid β antibodies. LBAS was found in 102 patients (31.9%) in the central nervous system, including the spinal cord; the OB was involved in 85 (26.6%). Among these 85 patients, 2 had LBAS only in the anterior olfactory nucleus, 14 in the peripheral OB only, and 69 in both areas. In 5 patients, Lewy bodies were found only in the OB by hematoxylin and eosin stain; 3 of these patients had Alzheimer disease, and all had LBAS. Very few tyrosine hydroxylase-immunoreactive periglomerular cells exhibited LBAS. All 35 LBAS patients with pigmentation loss in the substantia nigra had LBAS in the OB. LBAS in the amygdala was more strongly correlated with LBAS in the anterior olfactory nucleus than with that in the OB periphery. LBAS did not correlate with systemic tauopathy or amyloid β amyloidosis. These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>alpha-Synuclein - metabolism</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lewy Bodies - metabolism</subject><subject>Lewy Bodies - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental Status Schedule</subject><subject>Neurology</subject><subject>Olfactory Bulb - metabolism</subject><subject>Olfactory Bulb - pathology</subject><subject>Serine - metabolism</subject><subject>Spinal Cord - metabolism</subject><subject>Spinal Cord - pathology</subject><subject>Statistics as Topic</subject><subject>tau Proteins - metabolism</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><subject>Ubiquitin - metabolism</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u1DAUhS0EokPhDRDyBnYp14njn2WpBlpp1Er8bNhEjn3dCXicwU405LF4EZ4JoxmBxILF1dl85-jqI-Q5gwsGWr6-Xd9eQA-swYYppnrOavGArFjb8kq0Uj0kK4C6rhoQ-ow8yfkLAGjQ_DE5Y0oXQvMV-XwT7eAwWqQmOrr-PmGc6OjpBg8LfTO6pXqPwUzo6M8f1YclzjbgEMe9mbYLHSK9vB_iPb2edybSu-CNncZUinPon5JH3oSMz055Tj69XX-8uq42d-9uri43leWKiUqAaqRX6K1rlONGOleOiVYDM7pFL2qnZat83XIukQvruFQAVipE6frmnLw67u7T-G3GPHW7IVsMwUQc59wJLRvFtSogP4I2jTkn9N0-DTuTlo5B99tpV5x2_zottRen_bnfoftbOkkswMsTYLI1wSdTnOY_XF2scwFN4dSRO4xhwpS_hvmAqduiCdP2_z_8Amj0khA</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Sengoku, Renpei</creator><creator>Saito, Yuko</creator><creator>Ikemura, Masako</creator><creator>Hatsuta, Hiroyuki</creator><creator>Sakiyama, Yoshio</creator><creator>Kanemaru, Kazutomi</creator><creator>Arai, Tomio</creator><creator>Sawabe, Motoji</creator><creator>Tanaka, Noriko</creator><creator>Mochizuki, Hideki</creator><creator>Inoue, Kiyoharu</creator><creator>Murayama, Shigeo</creator><general>American Association of Neuropathologists, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200811</creationdate><title>Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb</title><author>Sengoku, Renpei ; Saito, Yuko ; Ikemura, Masako ; Hatsuta, Hiroyuki ; Sakiyama, Yoshio ; Kanemaru, Kazutomi ; Arai, Tomio ; Sawabe, Motoji ; Tanaka, Noriko ; Mochizuki, Hideki ; Inoue, Kiyoharu ; Murayama, Shigeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4816-60837f8efcd38d4a7dda7d165901a95ef62d9758f25447e46cd47800c78ee7db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>alpha-Synuclein - metabolism</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lewy Bodies - metabolism</topic><topic>Lewy Bodies - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental Status Schedule</topic><topic>Neurology</topic><topic>Olfactory Bulb - metabolism</topic><topic>Olfactory Bulb - pathology</topic><topic>Serine - metabolism</topic><topic>Spinal Cord - metabolism</topic><topic>Spinal Cord - pathology</topic><topic>Statistics as Topic</topic><topic>tau Proteins - metabolism</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><topic>Ubiquitin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sengoku, Renpei</creatorcontrib><creatorcontrib>Saito, Yuko</creatorcontrib><creatorcontrib>Ikemura, Masako</creatorcontrib><creatorcontrib>Hatsuta, Hiroyuki</creatorcontrib><creatorcontrib>Sakiyama, Yoshio</creatorcontrib><creatorcontrib>Kanemaru, Kazutomi</creatorcontrib><creatorcontrib>Arai, Tomio</creatorcontrib><creatorcontrib>Sawabe, Motoji</creatorcontrib><creatorcontrib>Tanaka, Noriko</creatorcontrib><creatorcontrib>Mochizuki, Hideki</creatorcontrib><creatorcontrib>Inoue, Kiyoharu</creatorcontrib><creatorcontrib>Murayama, Shigeo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuropathology and experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sengoku, Renpei</au><au>Saito, Yuko</au><au>Ikemura, Masako</au><au>Hatsuta, Hiroyuki</au><au>Sakiyama, Yoshio</au><au>Kanemaru, Kazutomi</au><au>Arai, Tomio</au><au>Sawabe, Motoji</au><au>Tanaka, Noriko</au><au>Mochizuki, Hideki</au><au>Inoue, Kiyoharu</au><au>Murayama, Shigeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb</atitle><jtitle>Journal of neuropathology and experimental neurology</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>67</volume><issue>11</issue><spage>1072</spage><epage>1083</epage><pages>1072-1083</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><coden>JNENAD</coden><abstract>We investigated the incidence and extent of Lewy body (LB)-related α-synucleinopathy (LBAS) in the olfactory bulb (OB) in 320 consecutive autopsy patients from a general geriatric hospital (mean age, 81.5 ± 8.5 years). Paraffin sections were immunostained with anti-phosphorylated α-synuclein, tyrosine hydroxylase, phosphorylated tau, and amyloid β antibodies. LBAS was found in 102 patients (31.9%) in the central nervous system, including the spinal cord; the OB was involved in 85 (26.6%). Among these 85 patients, 2 had LBAS only in the anterior olfactory nucleus, 14 in the peripheral OB only, and 69 in both areas. In 5 patients, Lewy bodies were found only in the OB by hematoxylin and eosin stain; 3 of these patients had Alzheimer disease, and all had LBAS. Very few tyrosine hydroxylase-immunoreactive periglomerular cells exhibited LBAS. All 35 LBAS patients with pigmentation loss in the substantia nigra had LBAS in the OB. LBAS in the amygdala was more strongly correlated with LBAS in the anterior olfactory nucleus than with that in the OB periphery. LBAS did not correlate with systemic tauopathy or amyloid β amyloidosis. These results indicate a high incidence of LBAS in the aging human OB; they also suggest that LBAS extends from the periphery to the anterior olfactory nucleus and results in clinical manifestations of LB disease.</abstract><cop>Hagerstown, MD</cop><pub>American Association of Neuropathologists, Inc</pub><pmid>18957894</pmid><doi>10.1097/NEN.0b013e31818b4126</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| source | Journals@Ovid Ovid Autoload; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Aged, 80 and over Aging - pathology alpha-Synuclein - metabolism Amyloid beta-Peptides - metabolism Biological and medical sciences Brain - metabolism Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Incidence Lewy Bodies - metabolism Lewy Bodies - pathology Male Medical sciences Mental Status Schedule Neurology Olfactory Bulb - metabolism Olfactory Bulb - pathology Serine - metabolism Spinal Cord - metabolism Spinal Cord - pathology Statistics as Topic tau Proteins - metabolism Tyrosine 3-Monooxygenase - metabolism Ubiquitin - metabolism |
| title | Incidence and Extent of Lewy Body-Related α-Synucleinopathy in Aging Human Olfactory Bulb |
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