Cutting Edge: Generation of IL-18 Receptor-Deficient Mice: Evidence for IL-1 Receptor-Related Protein as an Essential IL-18 Binding Receptor

IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1 cell response. Recently IL-1R-related protein (IL-1Rrp) has been cloned as the receptor for IL-18. However, the functional role of IL-1Rrp is still controversial due to its low affinity to IL-18 as well as...

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Veröffentlicht in:	The Journal of immunology (1950) 1999-05, Vol.162 (9), p.5041-5044
Hauptverfasser:	Hoshino, Katsuaki, Tsutsui, Hiroko, Kawai, Taro, Takeda, Kiyoshi, Nakanishi, Kenji, Takeda, Yoshifumi, Akira, Shizuo
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cytotoxicity, Immunologic - genetics DNA - immunology Enzyme Activation - genetics Enzyme Activation - immunology Gene Targeting Interleukin-18 - metabolism Interleukin-18 - physiology Interleukin-18 Receptor alpha Subunit JNK Mitogen-Activated Protein Kinases Killer Cells, Natural - immunology Killer Cells, Natural - pathology Mice Mice, Knockout - genetics Mice, Knockout - immunology Mitogen-Activated Protein Kinases NF-kappa B - metabolism Protein Binding - genetics Protein Binding - immunology Proteins - genetics Proteins - metabolism Receptors, Interleukin - deficiency Receptors, Interleukin - genetics Receptors, Interleukin-18 Sequence Deletion Spleen - immunology Spleen - pathology Th1 Cells - pathology
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