Undetectable Serum Thyroglobulin in a Patient With Metastatic Follicular Thyroid Cancer
The case of a 54-year-old woman with metastatic follicular thyroid cancer and undetectable serum thyroglobulin is presented. Many years after the patient had a subtotal thyroidectomy for a large goiter that had no clear evidence of malignancy, metastatic bone disease developed. When the bone metasta...
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| Veröffentlicht in: | Clinical nuclear medicine 1999-05, Vol.24 (5), p.346-349 |
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| container_title | Clinical nuclear medicine |
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| creator | MERTENS, ILSE J. R DE KLERK, JOHN M. H ZELISSEN, PIERRE M. J THIJSSEN, JOS H. H SIE-GO, DAISY M. D. S HAN, SHIUW H VAN RIJK, PETER P |
| description | The case of a 54-year-old woman with metastatic follicular thyroid cancer and undetectable serum thyroglobulin is presented. Many years after the patient had a subtotal thyroidectomy for a large goiter that had no clear evidence of malignancy, metastatic bone disease developed. When the bone metastases were detected and during the follow-up period, serum thyroglobulin values remained undetectable, but radioiodine uptake in the metastases was abundant. This case indicates that the combination of I-131 scintigraphy and serum thyroglobulin values is superior to the measurement of serum thyroglobulin alone in detecting well-differentiated, metastatic thyroid cancer. |
| doi_str_mv | 10.1097/00003072-199905000-00011 |
| format | Article |
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R ; DE KLERK, JOHN M. H ; ZELISSEN, PIERRE M. J ; THIJSSEN, JOS H. H ; SIE-GO, DAISY M. D. S ; HAN, SHIUW H ; VAN RIJK, PETER P</creator><creatorcontrib>MERTENS, ILSE J. R ; DE KLERK, JOHN M. H ; ZELISSEN, PIERRE M. J ; THIJSSEN, JOS H. H ; SIE-GO, DAISY M. D. S ; HAN, SHIUW H ; VAN RIJK, PETER P</creatorcontrib><description>The case of a 54-year-old woman with metastatic follicular thyroid cancer and undetectable serum thyroglobulin is presented. Many years after the patient had a subtotal thyroidectomy for a large goiter that had no clear evidence of malignancy, metastatic bone disease developed. When the bone metastases were detected and during the follow-up period, serum thyroglobulin values remained undetectable, but radioiodine uptake in the metastases was abundant. This case indicates that the combination of I-131 scintigraphy and serum thyroglobulin values is superior to the measurement of serum thyroglobulin alone in detecting well-differentiated, metastatic thyroid cancer.</description><identifier>ISSN: 0363-9762</identifier><identifier>EISSN: 1536-0229</identifier><identifier>DOI: 10.1097/00003072-199905000-00011</identifier><identifier>PMID: 10232475</identifier><identifier>CODEN: CNMEDK</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott Williams & Wilkins, Inc</publisher><subject>Adenocarcinoma, Follicular - diagnosis ; Adenocarcinoma, Follicular - diagnostic imaging ; Adenocarcinoma, Follicular - secondary ; Biological and medical sciences ; Bone Neoplasms - diagnosis ; Bone Neoplasms - diagnostic imaging ; Bone Neoplasms - secondary ; Endocrine glands. Genital system. Mammary gland ; Female ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Middle Aged ; Radionuclide Imaging ; Radionuclide investigations ; Thyroglobulin - blood ; Thyroid Neoplasms - pathology</subject><ispartof>Clinical nuclear medicine, 1999-05, Vol.24 (5), p.346-349</ispartof><rights>1999 Lippincott Williams & Wilkins, Inc.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3851-df15efdd4d63b6f8776a9a73f92f8402912df8d22923f5fbe8c0bd8ad8a0ddc3</citedby><cites>FETCH-LOGICAL-c3851-df15efdd4d63b6f8776a9a73f92f8402912df8d22923f5fbe8c0bd8ad8a0ddc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1790674$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10232475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MERTENS, ILSE J. 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This case indicates that the combination of I-131 scintigraphy and serum thyroglobulin values is superior to the measurement of serum thyroglobulin alone in detecting well-differentiated, metastatic thyroid cancer.</description><subject>Adenocarcinoma, Follicular - diagnosis</subject><subject>Adenocarcinoma, Follicular - diagnostic imaging</subject><subject>Adenocarcinoma, Follicular - secondary</subject><subject>Biological and medical sciences</subject><subject>Bone Neoplasms - diagnosis</subject><subject>Bone Neoplasms - diagnostic imaging</subject><subject>Bone Neoplasms - secondary</subject><subject>Endocrine glands. Genital system. Mammary gland</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><subject>Thyroglobulin - blood</subject><subject>Thyroid Neoplasms - pathology</subject><issn>0363-9762</issn><issn>1536-0229</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtPHCEYhomp0fXwFxoumt6NcpiB4bLZVNtEo4lrvCQMfHSnZWcsMNn472Wd7eFG8hECeV4ODwhhSi4oUfKSlMaJZBVVSpGmzKrSKT1AC9pwURHG1Ae0IFzwSknBjtFJSj8LIaioj9AxJYyzWjYL9PQ4OMhgs-kC4AeI0wav1i9x_BHGbgr9gEsZfG9yD0PGT31e41vIJuWyYvHVGEJvp2DinOodXprBQjxDh96EBOf78RStrr6ult-qm7vr78svN5XlbUMr52kD3rnaCd4J30opjDKSe8V8WxOmKHO-deU5jPvGd9Ba0rnWlCLOWX6KPs_bPsfx9wQp602fLIRgBhinpIWSXIi2LmA7gzaOKUXw-jn2GxNfNCV651T_car_OtVvTkv04_6MqduA-y84SyzApz1gkjXBx2KgT_84qYiQuyvUM7YdQ4aYfoVpC1GvwYS81u99KX8Fba6PDg</recordid><startdate>199905</startdate><enddate>199905</enddate><creator>MERTENS, ILSE J. 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Mammary gland</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><topic>Thyroglobulin - blood</topic><topic>Thyroid Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MERTENS, ILSE J. R</creatorcontrib><creatorcontrib>DE KLERK, JOHN M. H</creatorcontrib><creatorcontrib>ZELISSEN, PIERRE M. J</creatorcontrib><creatorcontrib>THIJSSEN, JOS H. H</creatorcontrib><creatorcontrib>SIE-GO, DAISY M. D. 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S</au><au>HAN, SHIUW H</au><au>VAN RIJK, PETER P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Undetectable Serum Thyroglobulin in a Patient With Metastatic Follicular Thyroid Cancer</atitle><jtitle>Clinical nuclear medicine</jtitle><addtitle>Clin Nucl Med</addtitle><date>1999-05</date><risdate>1999</risdate><volume>24</volume><issue>5</issue><spage>346</spage><epage>349</epage><pages>346-349</pages><issn>0363-9762</issn><eissn>1536-0229</eissn><coden>CNMEDK</coden><abstract>The case of a 54-year-old woman with metastatic follicular thyroid cancer and undetectable serum thyroglobulin is presented. Many years after the patient had a subtotal thyroidectomy for a large goiter that had no clear evidence of malignancy, metastatic bone disease developed. When the bone metastases were detected and during the follow-up period, serum thyroglobulin values remained undetectable, but radioiodine uptake in the metastases was abundant. This case indicates that the combination of I-131 scintigraphy and serum thyroglobulin values is superior to the measurement of serum thyroglobulin alone in detecting well-differentiated, metastatic thyroid cancer.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>10232475</pmid><doi>10.1097/00003072-199905000-00011</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9762 |
| ispartof | Clinical nuclear medicine, 1999-05, Vol.24 (5), p.346-349 |
| issn | 0363-9762 1536-0229 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma, Follicular - diagnosis Adenocarcinoma, Follicular - diagnostic imaging Adenocarcinoma, Follicular - secondary Biological and medical sciences Bone Neoplasms - diagnosis Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Endocrine glands. Genital system. Mammary gland Female Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Middle Aged Radionuclide Imaging Radionuclide investigations Thyroglobulin - blood Thyroid Neoplasms - pathology |
| title | Undetectable Serum Thyroglobulin in a Patient With Metastatic Follicular Thyroid Cancer |
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