Effects of phentolamine on tissue perfusion in pediatric cardiac surgery
Objective: To evaluate whether the deleterious effects of cardiopulmonary bypass (CPB) can be overcome by phentolamine-induced pharmacologic vasodilation in pediatric patients with congenital heart disease. Design: Prospective, randomized, clinical study. Setting: Single university hospital. Partici...
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| Veröffentlicht in: | Journal of cardiothoracic and vascular anesthesia 1999-04, Vol.13 (2), p.191-197 |
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| creator | Koner, Özge Tekin, Serap Köner, Ali Soybir, Nerime Seren, Sinan Karaoǧlu, Kamil |
| description | Objective:
To evaluate whether the deleterious effects of cardiopulmonary bypass (CPB) can be overcome by phentolamine-induced pharmacologic vasodilation in pediatric patients with congenital heart disease.
Design:
Prospective, randomized, clinical study.
Setting:
Single university hospital.
Participants:
Forty-three pediatric patients undergoing open cardiac surgery for repair of congenital heart disease.
Interventions:
Patients were randomly allocated into two groups. Patients in group 1 (n = 22) received 0.2 mg/kg of phentolamine during the cooling and rewarming periods of CPB. Group 2 patients (n = 21) did not receive phentolamine. Temperature measurements (rectal [R], nasopharyngeal [N], and toe [P]) and serum lactate values were obtained before, during, and after CPB; systemic oxygen consumption was evaluated during CPB.
Measurements and Main Results:
At the end of the CPB period and at the end of the operation, lactate values of group 1 (1.87 ± 0.37 and 1.8 ± 0.39 mmol/L, respectively) were significantly lower than values of group 2 (2.24 ± 0.28 and 2.33 ± 0.33 mmol/L;
p < 0.05 and
p < 0.05, respectively). At the beginning of the rewarming period N-R temperature gradients of group 1 (0.14°C ± 0.92°C) were lower than group 2 (−0.58°C ± 1.84°C) values (
p < 0.05). Central-peripheral temperature gradients of group 1 obtained at the end of the CPB period (N-R = 2.18°C ± 0.69°C; N-P = 7.84°C ± 1.54°C; R-P = 5.66°C ± 1.70°C) were significantly lower than the values of group 2 (N-R = 2.80°C ± 0.91°C, N-P = 9.97°C ± 2.02°C; R-P = 7.18°C ± 2.10°C;
p < 0.05;
p < 0.001;
p < 0.05). At the end of the operation values of group 1 (N-R = 0.48°C ± 0.31°C; N-P = 6.30°C ± 1.23°C; R-P = 5.82°C ± 1.16°C) were significantly lower than the values of group 2 (N-R = 0.94°C ± 0.56°C; N-P = 8.69°C ± 0.28°C; R-P = 7.75°C ± 2.15°C;
p < 0.05;
p < 0.001;
p < 0.001). The systemic oxygen consumption values of group 1 were higher than group 2 (6.26 ± 1.82
v 5.17 ± 1.05 mL/min/kg;
p < 0.05) after complete rewarming. Mean arterial pressure (MAP) values of group 1 (58.9 ± 6.4 mmHg) were lower than group 2 (63.4 ± 6.7 mmHg) at the period after CPB (
p = 0.03).
Conclusion:
The results suggest that the use of phentolamine during CPB is associated with limited systemic anaerobic metabolism and more uniform body perfusion. |
| doi_str_mv | 10.1016/S1053-0770(99)90086-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69735704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1053077099900861</els_id><sourcerecordid>69735704</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-c2c4ea1a77a2bf0e026d6b78243b0a6cb5afb7ecc27a4038fc02f53f8c485cb53</originalsourceid><addsrcrecordid>eNqFkE1L7TAQhoNc8fsnKF1cRBfVSdI0zUpE_ALBhboO6ZyJN9LTHpNW8N8bPeeiO1d5k3lmMjyM7XM44cDr0wcOSpagNRwZc2wAmrrka2yLKynKphLiT87_kU22ndILAOdK6Q22yUFIMEptsZtL7wnHVAy-WPyjfhw6Nw89FUNfjCGliYoFRT-lkB9Cny-z4MYYsEAXc8QiTfGZ4vsuW_euS7S3OnfY09Xl48VNeXd_fXtxfleiNDCWKLAix53WTrQeCEQ9q1vdiEq24GpslfOtJkShXQWy8QjCK-kbrBqVq3KHHS7nLuLwOlEa7TwkpK5zPQ1TsrXRUmmoMqiWIMYhpUjeLmKYu_huOdhPhfZLof30Y42xXwotz30Hqw-mdk6zH11LZxn4uwJcQtf56HoM6ZvTTWU4ZOxsiVG28RYo2oSBeswCYzZuZ0P4ZZMP0fyOJQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69735704</pqid></control><display><type>article</type><title>Effects of phentolamine on tissue perfusion in pediatric cardiac surgery</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Koner, Özge ; Tekin, Serap ; Köner, Ali ; Soybir, Nerime ; Seren, Sinan ; Karaoǧlu, Kamil</creator><creatorcontrib>Koner, Özge ; Tekin, Serap ; Köner, Ali ; Soybir, Nerime ; Seren, Sinan ; Karaoǧlu, Kamil</creatorcontrib><description><![CDATA[Objective:
To evaluate whether the deleterious effects of cardiopulmonary bypass (CPB) can be overcome by phentolamine-induced pharmacologic vasodilation in pediatric patients with congenital heart disease.
Design:
Prospective, randomized, clinical study.
Setting:
Single university hospital.
Participants:
Forty-three pediatric patients undergoing open cardiac surgery for repair of congenital heart disease.
Interventions:
Patients were randomly allocated into two groups. Patients in group 1 (n = 22) received 0.2 mg/kg of phentolamine during the cooling and rewarming periods of CPB. Group 2 patients (n = 21) did not receive phentolamine. Temperature measurements (rectal [R], nasopharyngeal [N], and toe [P]) and serum lactate values were obtained before, during, and after CPB; systemic oxygen consumption was evaluated during CPB.
Measurements and Main Results:
At the end of the CPB period and at the end of the operation, lactate values of group 1 (1.87 ± 0.37 and 1.8 ± 0.39 mmol/L, respectively) were significantly lower than values of group 2 (2.24 ± 0.28 and 2.33 ± 0.33 mmol/L;
p < 0.05 and
p < 0.05, respectively). At the beginning of the rewarming period N-R temperature gradients of group 1 (0.14°C ± 0.92°C) were lower than group 2 (−0.58°C ± 1.84°C) values (
p < 0.05). Central-peripheral temperature gradients of group 1 obtained at the end of the CPB period (N-R = 2.18°C ± 0.69°C; N-P = 7.84°C ± 1.54°C; R-P = 5.66°C ± 1.70°C) were significantly lower than the values of group 2 (N-R = 2.80°C ± 0.91°C, N-P = 9.97°C ± 2.02°C; R-P = 7.18°C ± 2.10°C;
p < 0.05;
p < 0.001;
p < 0.05). At the end of the operation values of group 1 (N-R = 0.48°C ± 0.31°C; N-P = 6.30°C ± 1.23°C; R-P = 5.82°C ± 1.16°C) were significantly lower than the values of group 2 (N-R = 0.94°C ± 0.56°C; N-P = 8.69°C ± 0.28°C; R-P = 7.75°C ± 2.15°C;
p < 0.05;
p < 0.001;
p < 0.001). The systemic oxygen consumption values of group 1 were higher than group 2 (6.26 ± 1.82
v 5.17 ± 1.05 mL/min/kg;
p < 0.05) after complete rewarming. Mean arterial pressure (MAP) values of group 1 (58.9 ± 6.4 mmHg) were lower than group 2 (63.4 ± 6.7 mmHg) at the period after CPB (
p = 0.03).
Conclusion:
The results suggest that the use of phentolamine during CPB is associated with limited systemic anaerobic metabolism and more uniform body perfusion.]]></description><identifier>ISSN: 1053-0770</identifier><identifier>EISSN: 1532-8422</identifier><identifier>DOI: 10.1016/S1053-0770(99)90086-1</identifier><identifier>PMID: 10230955</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Adrenergic alpha-Agonists - administration & dosage ; Adrenergic alpha-Agonists - therapeutic use ; Anaerobiosis - drug effects ; Anesthesia ; Anesthesia depending on type of surgery ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Circulation - drug effects ; Blood Pressure - drug effects ; Body Temperature - drug effects ; Cardiopulmonary Bypass - adverse effects ; Child ; Child, Preschool ; extracorporeal circulation ; Female ; Follow-Up Studies ; Heart Defects, Congenital - surgery ; Hemodynamics - drug effects ; Humans ; Hypothermia, Induced ; Infant ; Infant, Newborn ; Lactates - blood ; Male ; Medical sciences ; Oxygen Consumption - drug effects ; pediatric cardiac surgery ; phentolamine ; Phentolamine - administration & dosage ; Phentolamine - therapeutic use ; Prospective Studies ; Rewarming ; Skin Temperature - drug effects ; Thoracic and cardiovascular surgery. Cardiopulmonary bypass ; tissue perfusion ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - therapeutic use</subject><ispartof>Journal of cardiothoracic and vascular anesthesia, 1999-04, Vol.13 (2), p.191-197</ispartof><rights>1999</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-c2c4ea1a77a2bf0e026d6b78243b0a6cb5afb7ecc27a4038fc02f53f8c485cb53</citedby><cites>FETCH-LOGICAL-c390t-c2c4ea1a77a2bf0e026d6b78243b0a6cb5afb7ecc27a4038fc02f53f8c485cb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1053-0770(99)90086-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1784910$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10230955$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koner, Özge</creatorcontrib><creatorcontrib>Tekin, Serap</creatorcontrib><creatorcontrib>Köner, Ali</creatorcontrib><creatorcontrib>Soybir, Nerime</creatorcontrib><creatorcontrib>Seren, Sinan</creatorcontrib><creatorcontrib>Karaoǧlu, Kamil</creatorcontrib><title>Effects of phentolamine on tissue perfusion in pediatric cardiac surgery</title><title>Journal of cardiothoracic and vascular anesthesia</title><addtitle>J Cardiothorac Vasc Anesth</addtitle><description><![CDATA[Objective:
To evaluate whether the deleterious effects of cardiopulmonary bypass (CPB) can be overcome by phentolamine-induced pharmacologic vasodilation in pediatric patients with congenital heart disease.
Design:
Prospective, randomized, clinical study.
Setting:
Single university hospital.
Participants:
Forty-three pediatric patients undergoing open cardiac surgery for repair of congenital heart disease.
Interventions:
Patients were randomly allocated into two groups. Patients in group 1 (n = 22) received 0.2 mg/kg of phentolamine during the cooling and rewarming periods of CPB. Group 2 patients (n = 21) did not receive phentolamine. Temperature measurements (rectal [R], nasopharyngeal [N], and toe [P]) and serum lactate values were obtained before, during, and after CPB; systemic oxygen consumption was evaluated during CPB.
Measurements and Main Results:
At the end of the CPB period and at the end of the operation, lactate values of group 1 (1.87 ± 0.37 and 1.8 ± 0.39 mmol/L, respectively) were significantly lower than values of group 2 (2.24 ± 0.28 and 2.33 ± 0.33 mmol/L;
p < 0.05 and
p < 0.05, respectively). At the beginning of the rewarming period N-R temperature gradients of group 1 (0.14°C ± 0.92°C) were lower than group 2 (−0.58°C ± 1.84°C) values (
p < 0.05). Central-peripheral temperature gradients of group 1 obtained at the end of the CPB period (N-R = 2.18°C ± 0.69°C; N-P = 7.84°C ± 1.54°C; R-P = 5.66°C ± 1.70°C) were significantly lower than the values of group 2 (N-R = 2.80°C ± 0.91°C, N-P = 9.97°C ± 2.02°C; R-P = 7.18°C ± 2.10°C;
p < 0.05;
p < 0.001;
p < 0.05). At the end of the operation values of group 1 (N-R = 0.48°C ± 0.31°C; N-P = 6.30°C ± 1.23°C; R-P = 5.82°C ± 1.16°C) were significantly lower than the values of group 2 (N-R = 0.94°C ± 0.56°C; N-P = 8.69°C ± 0.28°C; R-P = 7.75°C ± 2.15°C;
p < 0.05;
p < 0.001;
p < 0.001). The systemic oxygen consumption values of group 1 were higher than group 2 (6.26 ± 1.82
v 5.17 ± 1.05 mL/min/kg;
p < 0.05) after complete rewarming. Mean arterial pressure (MAP) values of group 1 (58.9 ± 6.4 mmHg) were lower than group 2 (63.4 ± 6.7 mmHg) at the period after CPB (
p = 0.03).
Conclusion:
The results suggest that the use of phentolamine during CPB is associated with limited systemic anaerobic metabolism and more uniform body perfusion.]]></description><subject>Adrenergic alpha-Agonists - administration & dosage</subject><subject>Adrenergic alpha-Agonists - therapeutic use</subject><subject>Anaerobiosis - drug effects</subject><subject>Anesthesia</subject><subject>Anesthesia depending on type of surgery</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Circulation - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Body Temperature - drug effects</subject><subject>Cardiopulmonary Bypass - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>extracorporeal circulation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Defects, Congenital - surgery</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypothermia, Induced</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Lactates - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oxygen Consumption - drug effects</subject><subject>pediatric cardiac surgery</subject><subject>phentolamine</subject><subject>Phentolamine - administration & dosage</subject><subject>Phentolamine - therapeutic use</subject><subject>Prospective Studies</subject><subject>Rewarming</subject><subject>Skin Temperature - drug effects</subject><subject>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</subject><subject>tissue perfusion</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>1053-0770</issn><issn>1532-8422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1L7TAQhoNc8fsnKF1cRBfVSdI0zUpE_ALBhboO6ZyJN9LTHpNW8N8bPeeiO1d5k3lmMjyM7XM44cDr0wcOSpagNRwZc2wAmrrka2yLKynKphLiT87_kU22ndILAOdK6Q22yUFIMEptsZtL7wnHVAy-WPyjfhw6Nw89FUNfjCGliYoFRT-lkB9Cny-z4MYYsEAXc8QiTfGZ4vsuW_euS7S3OnfY09Xl48VNeXd_fXtxfleiNDCWKLAix53WTrQeCEQ9q1vdiEq24GpslfOtJkShXQWy8QjCK-kbrBqVq3KHHS7nLuLwOlEa7TwkpK5zPQ1TsrXRUmmoMqiWIMYhpUjeLmKYu_huOdhPhfZLof30Y42xXwotz30Hqw-mdk6zH11LZxn4uwJcQtf56HoM6ZvTTWU4ZOxsiVG28RYo2oSBeswCYzZuZ0P4ZZMP0fyOJQ</recordid><startdate>19990401</startdate><enddate>19990401</enddate><creator>Koner, Özge</creator><creator>Tekin, Serap</creator><creator>Köner, Ali</creator><creator>Soybir, Nerime</creator><creator>Seren, Sinan</creator><creator>Karaoǧlu, Kamil</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990401</creationdate><title>Effects of phentolamine on tissue perfusion in pediatric cardiac surgery</title><author>Koner, Özge ; Tekin, Serap ; Köner, Ali ; Soybir, Nerime ; Seren, Sinan ; Karaoǧlu, Kamil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-c2c4ea1a77a2bf0e026d6b78243b0a6cb5afb7ecc27a4038fc02f53f8c485cb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adrenergic alpha-Agonists - administration & dosage</topic><topic>Adrenergic alpha-Agonists - therapeutic use</topic><topic>Anaerobiosis - drug effects</topic><topic>Anesthesia</topic><topic>Anesthesia depending on type of surgery</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Circulation - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Body Temperature - drug effects</topic><topic>Cardiopulmonary Bypass - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>extracorporeal circulation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Defects, Congenital - surgery</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypothermia, Induced</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Lactates - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oxygen Consumption - drug effects</topic><topic>pediatric cardiac surgery</topic><topic>phentolamine</topic><topic>Phentolamine - administration & dosage</topic><topic>Phentolamine - therapeutic use</topic><topic>Prospective Studies</topic><topic>Rewarming</topic><topic>Skin Temperature - drug effects</topic><topic>Thoracic and cardiovascular surgery. Cardiopulmonary bypass</topic><topic>tissue perfusion</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koner, Özge</creatorcontrib><creatorcontrib>Tekin, Serap</creatorcontrib><creatorcontrib>Köner, Ali</creatorcontrib><creatorcontrib>Soybir, Nerime</creatorcontrib><creatorcontrib>Seren, Sinan</creatorcontrib><creatorcontrib>Karaoǧlu, Kamil</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koner, Özge</au><au>Tekin, Serap</au><au>Köner, Ali</au><au>Soybir, Nerime</au><au>Seren, Sinan</au><au>Karaoǧlu, Kamil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of phentolamine on tissue perfusion in pediatric cardiac surgery</atitle><jtitle>Journal of cardiothoracic and vascular anesthesia</jtitle><addtitle>J Cardiothorac Vasc Anesth</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>13</volume><issue>2</issue><spage>191</spage><epage>197</epage><pages>191-197</pages><issn>1053-0770</issn><eissn>1532-8422</eissn><abstract><![CDATA[Objective:
To evaluate whether the deleterious effects of cardiopulmonary bypass (CPB) can be overcome by phentolamine-induced pharmacologic vasodilation in pediatric patients with congenital heart disease.
Design:
Prospective, randomized, clinical study.
Setting:
Single university hospital.
Participants:
Forty-three pediatric patients undergoing open cardiac surgery for repair of congenital heart disease.
Interventions:
Patients were randomly allocated into two groups. Patients in group 1 (n = 22) received 0.2 mg/kg of phentolamine during the cooling and rewarming periods of CPB. Group 2 patients (n = 21) did not receive phentolamine. Temperature measurements (rectal [R], nasopharyngeal [N], and toe [P]) and serum lactate values were obtained before, during, and after CPB; systemic oxygen consumption was evaluated during CPB.
Measurements and Main Results:
At the end of the CPB period and at the end of the operation, lactate values of group 1 (1.87 ± 0.37 and 1.8 ± 0.39 mmol/L, respectively) were significantly lower than values of group 2 (2.24 ± 0.28 and 2.33 ± 0.33 mmol/L;
p < 0.05 and
p < 0.05, respectively). At the beginning of the rewarming period N-R temperature gradients of group 1 (0.14°C ± 0.92°C) were lower than group 2 (−0.58°C ± 1.84°C) values (
p < 0.05). Central-peripheral temperature gradients of group 1 obtained at the end of the CPB period (N-R = 2.18°C ± 0.69°C; N-P = 7.84°C ± 1.54°C; R-P = 5.66°C ± 1.70°C) were significantly lower than the values of group 2 (N-R = 2.80°C ± 0.91°C, N-P = 9.97°C ± 2.02°C; R-P = 7.18°C ± 2.10°C;
p < 0.05;
p < 0.001;
p < 0.05). At the end of the operation values of group 1 (N-R = 0.48°C ± 0.31°C; N-P = 6.30°C ± 1.23°C; R-P = 5.82°C ± 1.16°C) were significantly lower than the values of group 2 (N-R = 0.94°C ± 0.56°C; N-P = 8.69°C ± 0.28°C; R-P = 7.75°C ± 2.15°C;
p < 0.05;
p < 0.001;
p < 0.001). The systemic oxygen consumption values of group 1 were higher than group 2 (6.26 ± 1.82
v 5.17 ± 1.05 mL/min/kg;
p < 0.05) after complete rewarming. Mean arterial pressure (MAP) values of group 1 (58.9 ± 6.4 mmHg) were lower than group 2 (63.4 ± 6.7 mmHg) at the period after CPB (
p = 0.03).
Conclusion:
The results suggest that the use of phentolamine during CPB is associated with limited systemic anaerobic metabolism and more uniform body perfusion.]]></abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>10230955</pmid><doi>10.1016/S1053-0770(99)90086-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1053-0770 |
| ispartof | Journal of cardiothoracic and vascular anesthesia, 1999-04, Vol.13 (2), p.191-197 |
| issn | 1053-0770 1532-8422 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69735704 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adrenergic alpha-Agonists - administration & dosage Adrenergic alpha-Agonists - therapeutic use Anaerobiosis - drug effects Anesthesia Anesthesia depending on type of surgery Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Circulation - drug effects Blood Pressure - drug effects Body Temperature - drug effects Cardiopulmonary Bypass - adverse effects Child Child, Preschool extracorporeal circulation Female Follow-Up Studies Heart Defects, Congenital - surgery Hemodynamics - drug effects Humans Hypothermia, Induced Infant Infant, Newborn Lactates - blood Male Medical sciences Oxygen Consumption - drug effects pediatric cardiac surgery phentolamine Phentolamine - administration & dosage Phentolamine - therapeutic use Prospective Studies Rewarming Skin Temperature - drug effects Thoracic and cardiovascular surgery. Cardiopulmonary bypass tissue perfusion Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use |
| title | Effects of phentolamine on tissue perfusion in pediatric cardiac surgery |
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