The BiVACOR Rotary Biventricular Assist Device: Concept and In Vitro Investigation
The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end‐stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double‐sided magnetically and hydrodynamically suspended centrifugal impeller. The...
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| Veröffentlicht in: | Artificial organs 2008-10, Vol.32 (10), p.816-819 |
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| creator | Timms, Daniel Fraser, John Hayne, Mark Dunning, John McNeil, Keith Pearcy, Mark |
| description | The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end‐stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double‐sided magnetically and hydrodynamically suspended centrifugal impeller.
The performance of the device was assessed in a pulsatile mock circulation loop replicating end‐stage biventricular heart failure, and was shown to restore flow from pathological (2 L/min) to normal levels (5 L/min). A novel technique to balance the left/right outflow of the BiVAD was also investigated, for which a maximum relative left to right outflow differential of 1.8 L/min was achieved at normal physiologic afterloads.
The in vitro results encourage device progression to in vivo animal studies. Successful development of this BiVAD will provide a suitably miniature device for patients who require biventricular assistance. |
| doi_str_mv | 10.1111/j.1525-1594.2008.00633.x |
| format | Article |
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The performance of the device was assessed in a pulsatile mock circulation loop replicating end‐stage biventricular heart failure, and was shown to restore flow from pathological (2 L/min) to normal levels (5 L/min). A novel technique to balance the left/right outflow of the BiVAD was also investigated, for which a maximum relative left to right outflow differential of 1.8 L/min was achieved at normal physiologic afterloads.
The in vitro results encourage device progression to in vivo animal studies. Successful development of this BiVAD will provide a suitably miniature device for patients who require biventricular assistance.</description><identifier>ISSN: 0160-564X</identifier><identifier>EISSN: 1525-1594</identifier><identifier>DOI: 10.1111/j.1525-1594.2008.00633.x</identifier><identifier>PMID: 18959670</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Biventricular assist device ; Blood Flow Velocity - physiology ; Equipment Design - instrumentation ; Heart failure ; Heart Failure - therapy ; Heart-Assist Devices ; Hemorheology ; Humans ; Pulsatile Flow ; Rotary blood pump</subject><ispartof>Artificial organs, 2008-10, Vol.32 (10), p.816-819</ispartof><rights>2008, Copyright the Authors. Journal compilation © 2008, International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5513-911a186b6b056fba6b283a5554ccc9d34fb61ba779bf6d20ff842ad1bfcb1e503</citedby><cites>FETCH-LOGICAL-c5513-911a186b6b056fba6b283a5554ccc9d34fb61ba779bf6d20ff842ad1bfcb1e503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1525-1594.2008.00633.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1525-1594.2008.00633.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18959670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Timms, Daniel</creatorcontrib><creatorcontrib>Fraser, John</creatorcontrib><creatorcontrib>Hayne, Mark</creatorcontrib><creatorcontrib>Dunning, John</creatorcontrib><creatorcontrib>McNeil, Keith</creatorcontrib><creatorcontrib>Pearcy, Mark</creatorcontrib><title>The BiVACOR Rotary Biventricular Assist Device: Concept and In Vitro Investigation</title><title>Artificial organs</title><addtitle>Artif Organs</addtitle><description>The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end‐stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double‐sided magnetically and hydrodynamically suspended centrifugal impeller.
The performance of the device was assessed in a pulsatile mock circulation loop replicating end‐stage biventricular heart failure, and was shown to restore flow from pathological (2 L/min) to normal levels (5 L/min). A novel technique to balance the left/right outflow of the BiVAD was also investigated, for which a maximum relative left to right outflow differential of 1.8 L/min was achieved at normal physiologic afterloads.
The in vitro results encourage device progression to in vivo animal studies. Successful development of this BiVAD will provide a suitably miniature device for patients who require biventricular assistance.</description><subject>Biventricular assist device</subject><subject>Blood Flow Velocity - physiology</subject><subject>Equipment Design - instrumentation</subject><subject>Heart failure</subject><subject>Heart Failure - therapy</subject><subject>Heart-Assist Devices</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>Pulsatile Flow</subject><subject>Rotary blood pump</subject><issn>0160-564X</issn><issn>1525-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1O4zAURi3ECEpnXgF5xS4ZO_5JgtiUwhRERaWIYdhZtuOAS5oUOy3l7XFoBcvBG98rn-9e6RgAiFGMw_k9jzFLWIRZTuMEoSxGiBMSb_bA4PNhHwwQ5ihinD4cgiPv5wihlCJ-AA5xlrOcp2gAirsnA8_t_Wg8K2DRdtK9hXZtms5ZvaqlgyPvre_ghVlbbU7huG20WXZQNiW8buC97VwbirXxnX2UnW2bn-BHJWtvfu3uIfj75_JufBVNZ5Pr8WgaacYwiXKMJc644goxXinJVZIRyRijWuu8JLRSHCuZprmqeJmgqspoIkusKq2wYYgMwcl27tK1L6uwXyys16auZWPalRc8T0mQQf4L4pxiQrMezLagdq33zlRi6ewiKBEYiV68mIver-j9il68-BAvNiF6vNuxUgtTfgV3pgNwtgVebW3evj1YjGZFKEI82sbDX5jNZ1y6Z8FTkjLx73Yikit6TunNjSjIO9vHn68</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Timms, Daniel</creator><creator>Fraser, John</creator><creator>Hayne, Mark</creator><creator>Dunning, John</creator><creator>McNeil, Keith</creator><creator>Pearcy, Mark</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>The BiVACOR Rotary Biventricular Assist Device: Concept and In Vitro Investigation</title><author>Timms, Daniel ; Fraser, John ; Hayne, Mark ; Dunning, John ; McNeil, Keith ; Pearcy, Mark</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5513-911a186b6b056fba6b283a5554ccc9d34fb61ba779bf6d20ff842ad1bfcb1e503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biventricular assist device</topic><topic>Blood Flow Velocity - physiology</topic><topic>Equipment Design - instrumentation</topic><topic>Heart failure</topic><topic>Heart Failure - therapy</topic><topic>Heart-Assist Devices</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>Pulsatile Flow</topic><topic>Rotary blood pump</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Timms, Daniel</creatorcontrib><creatorcontrib>Fraser, John</creatorcontrib><creatorcontrib>Hayne, Mark</creatorcontrib><creatorcontrib>Dunning, John</creatorcontrib><creatorcontrib>McNeil, Keith</creatorcontrib><creatorcontrib>Pearcy, Mark</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Timms, Daniel</au><au>Fraser, John</au><au>Hayne, Mark</au><au>Dunning, John</au><au>McNeil, Keith</au><au>Pearcy, Mark</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The BiVACOR Rotary Biventricular Assist Device: Concept and In Vitro Investigation</atitle><jtitle>Artificial organs</jtitle><addtitle>Artif Organs</addtitle><date>2008-10</date><risdate>2008</risdate><volume>32</volume><issue>10</issue><spage>816</spage><epage>819</epage><pages>816-819</pages><issn>0160-564X</issn><eissn>1525-1594</eissn><abstract>The BiVACOR is a novel rotary Biventricular Assist Device (BiVAD) undergoing development to treat global end‐stage heart failure. The design includes left and right vanes positioned on a shared rotating hub to form a double‐sided magnetically and hydrodynamically suspended centrifugal impeller.
The performance of the device was assessed in a pulsatile mock circulation loop replicating end‐stage biventricular heart failure, and was shown to restore flow from pathological (2 L/min) to normal levels (5 L/min). A novel technique to balance the left/right outflow of the BiVAD was also investigated, for which a maximum relative left to right outflow differential of 1.8 L/min was achieved at normal physiologic afterloads.
The in vitro results encourage device progression to in vivo animal studies. Successful development of this BiVAD will provide a suitably miniature device for patients who require biventricular assistance.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>18959670</pmid><doi>10.1111/j.1525-1594.2008.00633.x</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Artificial organs, 2008-10, Vol.32 (10), p.816-819 |
| issn | 0160-564X 1525-1594 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Biventricular assist device Blood Flow Velocity - physiology Equipment Design - instrumentation Heart failure Heart Failure - therapy Heart-Assist Devices Hemorheology Humans Pulsatile Flow Rotary blood pump |
| title | The BiVACOR Rotary Biventricular Assist Device: Concept and In Vitro Investigation |
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