Regeneration of 4-thio-2′-deoxyuridine residues in DNA
We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated 4-thio-2′-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides. We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated-4-thio-2′-deoxyuridine residues by tr...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry letters 1999-04, Vol.9 (7), p.931-932 |
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| container_title | Bioorganic & medicinal chemistry letters |
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| creator | Coleman, Robert S. Pires, Richard M. |
| description | We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated 4-thio-2′-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides.
We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated-4-thio-2′-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides. |
| doi_str_mv | 10.1016/S0960-894X(99)00120-1 |
| format | Article |
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We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated-4-thio-2′-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides.</description><subject>Base Sequence</subject><subject>Carbohydrates. Nucleosides and nucleotides</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>DNA - chemistry</subject><subject>Exact sciences and technology</subject><subject>Nucleosides, nucleotides and oligonucleotides</subject><subject>Organic chemistry</subject><subject>Preparations and properties</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Thiouridine - analogs & derivatives</subject><subject>Thiouridine - chemistry</subject><issn>0960-894X</issn><issn>1464-3405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtOAyEUgGFiNFovj6CZhTG6QA8Dw8DKNPWaGE3UhTtC4Yxi2hmFqdGdz-Qj-SSObaPuXLH5Dgd-QjYZ7DNg8uAGtASqtLjb1XoPgOVA2QLpMSEF5QKKRdL7IStkNaXHDgkQYpmsMMg5SMZ7RF3jPdYYbRuaOmuqTND2ITQ0_3z_oB6b17dJDD7UmEVMwU8wZaHOji7762SpsqOEG_NzjdyeHN8OzujF1en5oH9BHeeqpQykLTWIEgB46SssSlFJxWBYWKWQoZds6D13ShQlFkUlrNBW-ILj0Mmcr5Gd2bVPsXnutrdmHJLD0cjW2EySkbrk3Y_LDhYz6GKTUsTKPMUwtvHNMDDfxcy0mPnOYbQ202KGdXNb8wWT4Rj9n6lZog5sz4FNzo6qaGsX0q8rdS6U6tjhjGEX4yVgNMkFrB36ENG1xjfhn5d8AeC-hv0</recordid><startdate>19990405</startdate><enddate>19990405</enddate><creator>Coleman, Robert S.</creator><creator>Pires, Richard M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990405</creationdate><title>Regeneration of 4-thio-2′-deoxyuridine residues in DNA</title><author>Coleman, Robert S. ; Pires, Richard M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-106a7904700037dfe574f6810b5a88e1ed61bdd3c8457e55f4a49a4d53ebc623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Base Sequence</topic><topic>Carbohydrates. Nucleosides and nucleotides</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>DNA - chemistry</topic><topic>Exact sciences and technology</topic><topic>Nucleosides, nucleotides and oligonucleotides</topic><topic>Organic chemistry</topic><topic>Preparations and properties</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Thiouridine - analogs & derivatives</topic><topic>Thiouridine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coleman, Robert S.</creatorcontrib><creatorcontrib>Pires, Richard M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coleman, Robert S.</au><au>Pires, Richard M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regeneration of 4-thio-2′-deoxyuridine residues in DNA</atitle><jtitle>Bioorganic & medicinal chemistry letters</jtitle><addtitle>Bioorg Med Chem Lett</addtitle><date>1999-04-05</date><risdate>1999</risdate><volume>9</volume><issue>7</issue><spage>931</spage><epage>932</epage><pages>931-932</pages><issn>0960-894X</issn><eissn>1464-3405</eissn><abstract>We report a facile, quantitative regeneration of the thiocarbonyl group from S-alkylated 4-thio-2′-deoxyuridine residues by treatment with NaSH within oligodeoxynucleotides.
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| fulltext | fulltext |
| identifier | ISSN: 0960-894X |
| ispartof | Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (7), p.931-932 |
| issn | 0960-894X 1464-3405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69734647 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Base Sequence Carbohydrates. Nucleosides and nucleotides Chemistry Chromatography, High Pressure Liquid DNA - chemistry Exact sciences and technology Nucleosides, nucleotides and oligonucleotides Organic chemistry Preparations and properties Spectrophotometry, Ultraviolet Thiouridine - analogs & derivatives Thiouridine - chemistry |
| title | Regeneration of 4-thio-2′-deoxyuridine residues in DNA |
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