BCR/ABL rearrangement and leukemia phenotype
Since the discovery that Philadelphia chromosome translocation is characterized, at the molecular level, by different types of BCR/ABL gene rearrangements, the issue of the relationship between the hybrid gene structure and the disease phenotype has puzzled clinical and molecular hematologists. Notw...
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| Veröffentlicht in: | Leukemia 1999-04, Vol.13 Suppl 1, p.S96-S96 |
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| container_title | Leukemia |
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| creator | Saglio, G Pane, F Martinelli, G Guerrasio, A |
| description | Since the discovery that Philadelphia chromosome translocation is characterized, at the molecular level, by different types of BCR/ABL gene rearrangements, the issue of the relationship between the hybrid gene structure and the disease phenotype has puzzled clinical and molecular hematologists. Notwithstanding the body of data accumulated in the last few years, this issue is at present largely unsettled. However, recent observations contributed to fill some gaps in the picture unravelling new links between molecular structure and clinical features. |
| doi_str_mv | 10.1038/sj.leu.2401321 |
| format | Article |
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Notwithstanding the body of data accumulated in the last few years, this issue is at present largely unsettled. 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| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Nature Journals Online |
| subjects | Animals BCR-ABL protein BCR-ABL1 gene Cell Differentiation Fusion Proteins, bcr-abl - classification Fusion Proteins, bcr-abl - genetics Genes, abl Humans Leukemia Leukemia - classification Leukemia - genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics Leukemia, Myeloid, Acute - genetics Leukemia, Myelomonocytic, Acute - genetics Mice Mice, Transgenic Neoplastic Stem Cells - chemistry Phenotype Phenotypes Philadelphia Chromosome Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Protein Isoforms - genetics |
| title | BCR/ABL rearrangement and leukemia phenotype |
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