Saccades and multisaccadic gaze shifts are gated by different pontine omnipause neurons in head-fixed cats

Pontine omnipause neurons (OPNs) have so far been considered as forming a homogeneous group of neurons whose tonic firing stops during the duration of saccades, when the head is immobilized. In cats, they pause for the total duration of gaze shifts, when the head is free to move. In the present stud...

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Veröffentlicht in:Experimental brain research 1999-04, Vol.125 (3), p.287-301
Hauptverfasser: PETIT, J, KLAM, F, GRANTYN, A, BERTHOZ, A
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KLAM, F
GRANTYN, A
BERTHOZ, A
description Pontine omnipause neurons (OPNs) have so far been considered as forming a homogeneous group of neurons whose tonic firing stops during the duration of saccades, when the head is immobilized. In cats, they pause for the total duration of gaze shifts, when the head is free to move. In the present study, carried out on alert cats with fixed heads, we present observations made during self-initiated saccades and during tracking of a moving target which show that the OPN population is not homogeneous. Of the 76 OPNs we identified, 39 were found to have characteristics similar to those of previously described neurons, "saccade" (S-) OPNs: (1) the durations of their pauses were significantly correlated with the durations of saccades; (2) the discharge ceased shortly before saccade onset and resumed before saccade end; (3) visual responses to target motion were excitatory; and (4) during tracking, S-OPNs interrupted the discharge for the duration of saccades and resumed firing during perisaccadic "drifts". However, the characteristics of 37 neurons ("complex" (C-) OPNs) were different: (1) the pause duration was not correlated with the duration of self-initiated saccades; (2) time lead of pause onsets relative to saccades was, on average, longer than in the group of S-OPNs, and firing resumed after the saccade end; (3) visual target motion suppressed tonic discharges; and (4) during tracking, firing was interrupted for the total duration of gaze shifts, including not only saccades but also perisaccadic "drifts". We conclude that cat OPNs can be subdivided into two main groups. The first comprises neurons whose firing patterns are compatible with gating individual saccades ("saccade" OPNs). The second group consists of "complex" OPNs whose firing characteristics are appropriate to gate total gaze displacements rather than individual saccades. The function of these neurons may be to disinhibit pontobulbar circuits participating in the generation of saccade sequences and associated perisaccadic drifts.
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Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Head - physiology</topic><topic>Linear Models</topic><topic>Motion Perception - physiology</topic><topic>Neurons - physiology</topic><topic>Photic Stimulation</topic><topic>Pons - cytology</topic><topic>Pons - physiology</topic><topic>Posture - physiology</topic><topic>Saccades - physiology</topic><topic>Space life sciences</topic><topic>Stereotaxic Techniques</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PETIT, J</creatorcontrib><creatorcontrib>KLAM, F</creatorcontrib><creatorcontrib>GRANTYN, A</creatorcontrib><creatorcontrib>BERTHOZ, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PETIT, J</au><au>KLAM, F</au><au>GRANTYN, A</au><au>BERTHOZ, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Saccades and multisaccadic gaze shifts are gated by different pontine omnipause neurons in head-fixed cats</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>1999-04-01</date><risdate>1999</risdate><volume>125</volume><issue>3</issue><spage>287</spage><epage>301</epage><pages>287-301</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Pontine omnipause neurons (OPNs) have so far been considered as forming a homogeneous group of neurons whose tonic firing stops during the duration of saccades, when the head is immobilized. 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subjects Action Potentials - physiology
Animals
Biological and medical sciences
Cats
Evoked Potentials, Visual - physiology
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Head - physiology
Linear Models
Motion Perception - physiology
Neurons - physiology
Photic Stimulation
Pons - cytology
Pons - physiology
Posture - physiology
Saccades - physiology
Space life sciences
Stereotaxic Techniques
Vertebrates: nervous system and sense organs
title Saccades and multisaccadic gaze shifts are gated by different pontine omnipause neurons in head-fixed cats
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