Heart Rate Variability and Disease Characteristics in Patients with COPD
Heart rate variability (HRV) is reduced in patients with chronic obstructive pulmonary disease (COPD). However, the relationships among HRV and characteristics of COPD are unknown. The aim of this study was to characterize HRV in patients with COPD and to verify the correlation of HRV measured durin...
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| Veröffentlicht in: | Lung 2008-12, Vol.186 (6), p.393-401 |
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| creator | Camillo, Carlos A. Pitta, Fabio Possani, Heloíse V. Barbosa, Marcus V. R. A. Marques, Divina S. O. Cavalheri, Vinícius Probst, Vanessa S. Brunetto, Antonio F. |
| description | Heart rate variability (HRV) is reduced in patients with chronic obstructive pulmonary disease (COPD). However, the relationships among HRV and characteristics of COPD are unknown. The aim of this study was to characterize HRV in patients with COPD and to verify the correlation of HRV measured during rest with disease severity and pulmonary, muscular, and functional impairment. Thirty-one patients with COPD (16 male; 66 ± 8 years; BMI = 24 ± 6 kg/m
2
; FEV
1
= 46 ± 16% predicted) without severe cardiac dysfunction were included. HRV assessment was performed by the head-up tilt test (HUTT), and the main variables used for analysis were SDNN index, LF/HF ratio, and R-R intervals. Other tests included spirometry, bioelectrical impedance, cardiopulmonary exercise test, 6-minute walk test, respiratory and peripheral muscle force, health-related quality of life and functional status questionnaires, and objective quantification of physical activity level in daily life with the DynaPort
®
and SenseWear
®
armband activity monitors, besides calculation of the BODE index. There was a statistical difference in all variables of HRV between the HUTT positions (lying and standing). There was no correlation of HRV with BODE index or FEV
1
. Out of the BODE index, just the BMI was correlated with SDNN and R-R intervals (
r
= 0.44;
p
|
| doi_str_mv | 10.1007/s00408-008-9105-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69733802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1587272831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-bb5f2ad615f02c95767e0b1d51e06055b84cb44b4d27b9889683b1707a25a0343</originalsourceid><addsrcrecordid>eNp1kMFKAzEQhoMotlYfwIsED95WJ8lmkz1Kq1YotIh6Dclu1qZstzVJkb69KS0UBA9hDvnmn5kPoWsC9wRAPASAHGQG6ZUEeCZOUJ_kjGZEcDhFfWA5yWhieugihAUAEQXh56hHpCRcsryPxmOrfcRvOlr8qb3TxrUubrHuajxywepg8XCuva6i9S5EVwXsOjzT0dkuBvzj4hwPp7PRJTprdBvs1aEO0Mfz0_twnE2mL6_Dx0lWsaKMmTG8obpOazRAq5KLQlgwpObEQgGcG5lXJs9NXlNhSinLQjJDBAhNuU73sAG62-eu_ep7Y0NUSxcq27a6s6tNUEUpGJNAE3j7B1ysNr5LuynKSFEALWWCyB6q_CoEbxu19m6p_VYRUDvHau9YJcdq51iJ1HNzCN6Ypa2PHQepCaB7IKSv7sv64-T_U38BIC2ERw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>231660298</pqid></control><display><type>article</type><title>Heart Rate Variability and Disease Characteristics in Patients with COPD</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Camillo, Carlos A. ; Pitta, Fabio ; Possani, Heloíse V. ; Barbosa, Marcus V. R. A. ; Marques, Divina S. O. ; Cavalheri, Vinícius ; Probst, Vanessa S. ; Brunetto, Antonio F.</creator><creatorcontrib>Camillo, Carlos A. ; Pitta, Fabio ; Possani, Heloíse V. ; Barbosa, Marcus V. R. A. ; Marques, Divina S. O. ; Cavalheri, Vinícius ; Probst, Vanessa S. ; Brunetto, Antonio F.</creatorcontrib><description>Heart rate variability (HRV) is reduced in patients with chronic obstructive pulmonary disease (COPD). However, the relationships among HRV and characteristics of COPD are unknown. The aim of this study was to characterize HRV in patients with COPD and to verify the correlation of HRV measured during rest with disease severity and pulmonary, muscular, and functional impairment. Thirty-one patients with COPD (16 male; 66 ± 8 years; BMI = 24 ± 6 kg/m
2
; FEV
1
= 46 ± 16% predicted) without severe cardiac dysfunction were included. HRV assessment was performed by the head-up tilt test (HUTT), and the main variables used for analysis were SDNN index, LF/HF ratio, and R-R intervals. Other tests included spirometry, bioelectrical impedance, cardiopulmonary exercise test, 6-minute walk test, respiratory and peripheral muscle force, health-related quality of life and functional status questionnaires, and objective quantification of physical activity level in daily life with the DynaPort
®
and SenseWear
®
armband activity monitors, besides calculation of the BODE index. There was a statistical difference in all variables of HRV between the HUTT positions (lying and standing). There was no correlation of HRV with BODE index or FEV
1
. Out of the BODE index, just the BMI was correlated with SDNN and R-R intervals (
r
= 0.44;
p
< 0.05 and
r
= 0.37;
p
< 0.05, respectively). There was correlation between HRV reduction and a lower level of physical activity in daily life, besides worse health-related quality of life, functional status, and respiratory and peripheral muscle force. Cardiac autonomic function of patients with COPD is not related to disease severity but mainly to the level of physical activity in daily life.</description><identifier>ISSN: 0341-2040</identifier><identifier>EISSN: 1432-1750</identifier><identifier>DOI: 10.1007/s00408-008-9105-7</identifier><identifier>PMID: 18815834</identifier><identifier>CODEN: LUNGD9</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Activities of Daily Living ; Aged ; Autonomic Nervous System - physiopathology ; Chronic obstructive pulmonary disease ; Correlation analysis ; Dyspnea - physiopathology ; Exercise ; Exercise Tolerance - physiology ; Female ; Forced Expiratory Volume ; Heart rate ; Heart Rate - physiology ; Humans ; Logistic Models ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Motor Activity ; Pneumology/Respiratory System ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Quality of Life ; Respiratory Function Tests ; Severity of Illness Index ; Statistics, Nonparametric ; Surveys and Questionnaires ; Tilt-Table Test ; Vital Capacity</subject><ispartof>Lung, 2008-12, Vol.186 (6), p.393-401</ispartof><rights>Springer Science+Business Media, LLC 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-bb5f2ad615f02c95767e0b1d51e06055b84cb44b4d27b9889683b1707a25a0343</citedby><cites>FETCH-LOGICAL-c369t-bb5f2ad615f02c95767e0b1d51e06055b84cb44b4d27b9889683b1707a25a0343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00408-008-9105-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00408-008-9105-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18815834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camillo, Carlos A.</creatorcontrib><creatorcontrib>Pitta, Fabio</creatorcontrib><creatorcontrib>Possani, Heloíse V.</creatorcontrib><creatorcontrib>Barbosa, Marcus V. R. A.</creatorcontrib><creatorcontrib>Marques, Divina S. O.</creatorcontrib><creatorcontrib>Cavalheri, Vinícius</creatorcontrib><creatorcontrib>Probst, Vanessa S.</creatorcontrib><creatorcontrib>Brunetto, Antonio F.</creatorcontrib><title>Heart Rate Variability and Disease Characteristics in Patients with COPD</title><title>Lung</title><addtitle>Lung</addtitle><addtitle>Lung</addtitle><description>Heart rate variability (HRV) is reduced in patients with chronic obstructive pulmonary disease (COPD). However, the relationships among HRV and characteristics of COPD are unknown. The aim of this study was to characterize HRV in patients with COPD and to verify the correlation of HRV measured during rest with disease severity and pulmonary, muscular, and functional impairment. Thirty-one patients with COPD (16 male; 66 ± 8 years; BMI = 24 ± 6 kg/m
2
; FEV
1
= 46 ± 16% predicted) without severe cardiac dysfunction were included. HRV assessment was performed by the head-up tilt test (HUTT), and the main variables used for analysis were SDNN index, LF/HF ratio, and R-R intervals. Other tests included spirometry, bioelectrical impedance, cardiopulmonary exercise test, 6-minute walk test, respiratory and peripheral muscle force, health-related quality of life and functional status questionnaires, and objective quantification of physical activity level in daily life with the DynaPort
®
and SenseWear
®
armband activity monitors, besides calculation of the BODE index. There was a statistical difference in all variables of HRV between the HUTT positions (lying and standing). There was no correlation of HRV with BODE index or FEV
1
. Out of the BODE index, just the BMI was correlated with SDNN and R-R intervals (
r
= 0.44;
p
< 0.05 and
r
= 0.37;
p
< 0.05, respectively). There was correlation between HRV reduction and a lower level of physical activity in daily life, besides worse health-related quality of life, functional status, and respiratory and peripheral muscle force. Cardiac autonomic function of patients with COPD is not related to disease severity but mainly to the level of physical activity in daily life.</description><subject>Activities of Daily Living</subject><subject>Aged</subject><subject>Autonomic Nervous System - physiopathology</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Correlation analysis</subject><subject>Dyspnea - physiopathology</subject><subject>Exercise</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Pneumology/Respiratory System</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Quality of Life</subject><subject>Respiratory Function Tests</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Tilt-Table Test</subject><subject>Vital Capacity</subject><issn>0341-2040</issn><issn>1432-1750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMFKAzEQhoMotlYfwIsED95WJ8lmkz1Kq1YotIh6Dclu1qZstzVJkb69KS0UBA9hDvnmn5kPoWsC9wRAPASAHGQG6ZUEeCZOUJ_kjGZEcDhFfWA5yWhieugihAUAEQXh56hHpCRcsryPxmOrfcRvOlr8qb3TxrUubrHuajxywepg8XCuva6i9S5EVwXsOjzT0dkuBvzj4hwPp7PRJTprdBvs1aEO0Mfz0_twnE2mL6_Dx0lWsaKMmTG8obpOazRAq5KLQlgwpObEQgGcG5lXJs9NXlNhSinLQjJDBAhNuU73sAG62-eu_ep7Y0NUSxcq27a6s6tNUEUpGJNAE3j7B1ysNr5LuynKSFEALWWCyB6q_CoEbxu19m6p_VYRUDvHau9YJcdq51iJ1HNzCN6Ypa2PHQepCaB7IKSv7sv64-T_U38BIC2ERw</recordid><startdate>20081201</startdate><enddate>20081201</enddate><creator>Camillo, Carlos A.</creator><creator>Pitta, Fabio</creator><creator>Possani, Heloíse V.</creator><creator>Barbosa, Marcus V. R. A.</creator><creator>Marques, Divina S. O.</creator><creator>Cavalheri, Vinícius</creator><creator>Probst, Vanessa S.</creator><creator>Brunetto, Antonio F.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20081201</creationdate><title>Heart Rate Variability and Disease Characteristics in Patients with COPD</title><author>Camillo, Carlos A. ; Pitta, Fabio ; Possani, Heloíse V. ; Barbosa, Marcus V. R. A. ; Marques, Divina S. O. ; Cavalheri, Vinícius ; Probst, Vanessa S. ; Brunetto, Antonio F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-bb5f2ad615f02c95767e0b1d51e06055b84cb44b4d27b9889683b1707a25a0343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Activities of Daily Living</topic><topic>Aged</topic><topic>Autonomic Nervous System - physiopathology</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Correlation analysis</topic><topic>Dyspnea - physiopathology</topic><topic>Exercise</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Pneumology/Respiratory System</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Quality of Life</topic><topic>Respiratory Function Tests</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Tilt-Table Test</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camillo, Carlos A.</creatorcontrib><creatorcontrib>Pitta, Fabio</creatorcontrib><creatorcontrib>Possani, Heloíse V.</creatorcontrib><creatorcontrib>Barbosa, Marcus V. R. A.</creatorcontrib><creatorcontrib>Marques, Divina S. O.</creatorcontrib><creatorcontrib>Cavalheri, Vinícius</creatorcontrib><creatorcontrib>Probst, Vanessa S.</creatorcontrib><creatorcontrib>Brunetto, Antonio F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Lung</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camillo, Carlos A.</au><au>Pitta, Fabio</au><au>Possani, Heloíse V.</au><au>Barbosa, Marcus V. R. A.</au><au>Marques, Divina S. O.</au><au>Cavalheri, Vinícius</au><au>Probst, Vanessa S.</au><au>Brunetto, Antonio F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heart Rate Variability and Disease Characteristics in Patients with COPD</atitle><jtitle>Lung</jtitle><stitle>Lung</stitle><addtitle>Lung</addtitle><date>2008-12-01</date><risdate>2008</risdate><volume>186</volume><issue>6</issue><spage>393</spage><epage>401</epage><pages>393-401</pages><issn>0341-2040</issn><eissn>1432-1750</eissn><coden>LUNGD9</coden><abstract>Heart rate variability (HRV) is reduced in patients with chronic obstructive pulmonary disease (COPD). However, the relationships among HRV and characteristics of COPD are unknown. The aim of this study was to characterize HRV in patients with COPD and to verify the correlation of HRV measured during rest with disease severity and pulmonary, muscular, and functional impairment. Thirty-one patients with COPD (16 male; 66 ± 8 years; BMI = 24 ± 6 kg/m
2
; FEV
1
= 46 ± 16% predicted) without severe cardiac dysfunction were included. HRV assessment was performed by the head-up tilt test (HUTT), and the main variables used for analysis were SDNN index, LF/HF ratio, and R-R intervals. Other tests included spirometry, bioelectrical impedance, cardiopulmonary exercise test, 6-minute walk test, respiratory and peripheral muscle force, health-related quality of life and functional status questionnaires, and objective quantification of physical activity level in daily life with the DynaPort
®
and SenseWear
®
armband activity monitors, besides calculation of the BODE index. There was a statistical difference in all variables of HRV between the HUTT positions (lying and standing). There was no correlation of HRV with BODE index or FEV
1
. Out of the BODE index, just the BMI was correlated with SDNN and R-R intervals (
r
= 0.44;
p
< 0.05 and
r
= 0.37;
p
< 0.05, respectively). There was correlation between HRV reduction and a lower level of physical activity in daily life, besides worse health-related quality of life, functional status, and respiratory and peripheral muscle force. Cardiac autonomic function of patients with COPD is not related to disease severity but mainly to the level of physical activity in daily life.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>18815834</pmid><doi>10.1007/s00408-008-9105-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0341-2040 |
| ispartof | Lung, 2008-12, Vol.186 (6), p.393-401 |
| issn | 0341-2040 1432-1750 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69733802 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Activities of Daily Living Aged Autonomic Nervous System - physiopathology Chronic obstructive pulmonary disease Correlation analysis Dyspnea - physiopathology Exercise Exercise Tolerance - physiology Female Forced Expiratory Volume Heart rate Heart Rate - physiology Humans Logistic Models Male Medicine Medicine & Public Health Middle Aged Motor Activity Pneumology/Respiratory System Pulmonary Disease, Chronic Obstructive - physiopathology Quality of Life Respiratory Function Tests Severity of Illness Index Statistics, Nonparametric Surveys and Questionnaires Tilt-Table Test Vital Capacity |
| title | Heart Rate Variability and Disease Characteristics in Patients with COPD |
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