Apoptosis of thymic lymphoma clones by thymic epithelial cells: a putative model for ‘death by neglect’

We have previously described an in vitro system in which thymic epithelial cells induce apoptosis in CD4 +8 + thymocytes or thymic lymphoma cells, in the absence of an exogenous antigen. A thymic epithelial cell line (TEC) recapitulated the response, by inducing apoptosis in CD4 +8 + thymocytes of t...

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Veröffentlicht in:	Immunology letters 1999-04, Vol.67 (2), p.95-104
Hauptverfasser:	Zilberman, Yael, Yefenof, Eitan, Katzav, Shulamit, Dorogin, Anna, Rosenheimer-Goudsmid, Noga, Guy, Rina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Apoptosis Calcium - metabolism Cations, Divalent CD3 Complex - immunology Cell Cycle Proteins Cell Line, Transformed Coculture Techniques - methods Death by neglect Epithelial Cells - physiology Humans Lymphoma, T-Cell Mice Mice, Inbred BALB C Mice, Inbred C57BL Models, Biological Phosphorylation Protein Kinase C - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-vav T-cell receptor Thymic epithelial cell Thymic lymphoma Thymus Gland
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