Water transport in the immature rabbit collecting duct
Immature animals have limited ability to concentrate the urine. This is in part the result of end-organ resistance to arginine vasopressin (AVP). To characterize this response, we measured water absorption in microperfused cortical collecting ducts (iCCD) and outer medullary CD (iOMCD) derived from...
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| Veröffentlicht in: | Pediatric nephrology (Berlin, West) West), 1999-02, Vol.13 (2), p.103-107 |
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| creator | BONILLA-FELIX, M MATTI VEHASKARI, V HAMM, L. L |
| description | Immature animals have limited ability to concentrate the urine. This is in part the result of end-organ resistance to arginine vasopressin (AVP). To characterize this response, we measured water absorption in microperfused cortical collecting ducts (iCCD) and outer medullary CD (iOMCD) derived from 2- to 12-day-old rabbits. The roles of adenosine 3',5'-cyclic monophosphate (cAMP) and prostaglandins were investigated. Baseline osmotic water permeability (L(p), 10(-7) cm/atm per s) in the iCCD (20.3+/-2.4) and iOMCD (19.7+/-5.6) was not different from mature CCD (mCCD) (14.6+/-3.1). After AVP, L(p) in the iCCD (46.7+/-10.0) was significantly lower than in the mCCD (114.3+/-21.8). Neither stimulation with cAMP (85.6+/-51.3) nor inhibition of endogenous prostaglandin production with indomethacin (57.6+/-29.8) abolished the blunted response to AVP in the iCCD. We conclude that AVP-stimulated water transport in the iCCD is impaired. The disruption in AVP response is, at least in part, localized distal to cAMP, and is not mediated by prostaglandins. |
| doi_str_mv | 10.1007/s004670050572 |
| format | Article |
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L</creator><creatorcontrib>BONILLA-FELIX, M ; MATTI VEHASKARI, V ; HAMM, L. L</creatorcontrib><description>Immature animals have limited ability to concentrate the urine. This is in part the result of end-organ resistance to arginine vasopressin (AVP). To characterize this response, we measured water absorption in microperfused cortical collecting ducts (iCCD) and outer medullary CD (iOMCD) derived from 2- to 12-day-old rabbits. The roles of adenosine 3',5'-cyclic monophosphate (cAMP) and prostaglandins were investigated. Baseline osmotic water permeability (L(p), 10(-7) cm/atm per s) in the iCCD (20.3+/-2.4) and iOMCD (19.7+/-5.6) was not different from mature CCD (mCCD) (14.6+/-3.1). After AVP, L(p) in the iCCD (46.7+/-10.0) was significantly lower than in the mCCD (114.3+/-21.8). Neither stimulation with cAMP (85.6+/-51.3) nor inhibition of endogenous prostaglandin production with indomethacin (57.6+/-29.8) abolished the blunted response to AVP in the iCCD. We conclude that AVP-stimulated water transport in the iCCD is impaired. The disruption in AVP response is, at least in part, localized distal to cAMP, and is not mediated by prostaglandins.</description><identifier>ISSN: 0931-041X</identifier><identifier>EISSN: 1432-198X</identifier><identifier>DOI: 10.1007/s004670050572</identifier><identifier>PMID: 10228993</identifier><identifier>CODEN: PENED3</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Algorithms ; Animals ; Animals, Newborn ; Arginine Vasopressin - pharmacology ; Biological and medical sciences ; Biological Transport, Active ; Body Water - metabolism ; Cyclic AMP - pharmacology ; Cyclooxygenase Inhibitors - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Indomethacin - pharmacology ; Kidney Concentrating Ability ; Kidney Tubules, Collecting - metabolism ; Perfusion ; Prostaglandins - biosynthesis ; Rabbits ; Renal Agents - pharmacology ; Vertebrates: urinary system</subject><ispartof>Pediatric nephrology (Berlin, West), 1999-02, Vol.13 (2), p.103-107</ispartof><rights>1999 INIST-CNRS</rights><rights>IPNA - International Pediatric Nephrology Association New York, USA 1999</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-a6814d07005759be6a6729eeccbf9ef6cd951fd109201be4d4c06c4badcec453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1763368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10228993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BONILLA-FELIX, M</creatorcontrib><creatorcontrib>MATTI VEHASKARI, V</creatorcontrib><creatorcontrib>HAMM, L. L</creatorcontrib><title>Water transport in the immature rabbit collecting duct</title><title>Pediatric nephrology (Berlin, West)</title><addtitle>Pediatr Nephrol</addtitle><description>Immature animals have limited ability to concentrate the urine. This is in part the result of end-organ resistance to arginine vasopressin (AVP). To characterize this response, we measured water absorption in microperfused cortical collecting ducts (iCCD) and outer medullary CD (iOMCD) derived from 2- to 12-day-old rabbits. The roles of adenosine 3',5'-cyclic monophosphate (cAMP) and prostaglandins were investigated. Baseline osmotic water permeability (L(p), 10(-7) cm/atm per s) in the iCCD (20.3+/-2.4) and iOMCD (19.7+/-5.6) was not different from mature CCD (mCCD) (14.6+/-3.1). After AVP, L(p) in the iCCD (46.7+/-10.0) was significantly lower than in the mCCD (114.3+/-21.8). Neither stimulation with cAMP (85.6+/-51.3) nor inhibition of endogenous prostaglandin production with indomethacin (57.6+/-29.8) abolished the blunted response to AVP in the iCCD. We conclude that AVP-stimulated water transport in the iCCD is impaired. The disruption in AVP response is, at least in part, localized distal to cAMP, and is not mediated by prostaglandins.</description><subject>Algorithms</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biological Transport, Active</subject><subject>Body Water - metabolism</subject><subject>Cyclic AMP - pharmacology</subject><subject>Cyclooxygenase Inhibitors - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Indomethacin - pharmacology</subject><subject>Kidney Concentrating Ability</subject><subject>Kidney Tubules, Collecting - metabolism</subject><subject>Perfusion</subject><subject>Prostaglandins - biosynthesis</subject><subject>Rabbits</subject><subject>Renal Agents - pharmacology</subject><subject>Vertebrates: urinary system</subject><issn>0931-041X</issn><issn>1432-198X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpd0EtLw0AUhuFBFFurS7cSRNxFz9wzSyneoOCmYHdhMjnRlFzqzGThv29KC15WZ_Nw-HgJuaRwRwH0fQAQSgNIkJodkSkVnKXUZKtjMgXDaQqCribkLIQ1AGQyU6dkQoGxzBg-JerdRvRJ9LYLm97HpO6S-IlJ3bY2Dh4Tb4uijonrmwZdrLuPpBxcPCcnlW0CXhzujCyfHpfzl3Tx9vw6f1ikjgsZU6syKkrYzdPSFKis0swgOldUBivlSiNpVVIwDGiBohQOlBOFLR06IfmM3O7fbnz_NWCIeVsHh01jO-yHkCujORUgRnj9D677wXfjtJwxxnUmQY8o3SPn-xA8VvnG16313zmFfBcz_xNz9FeHp0PRYvlL7-uN4OYAbHC2qcaIrg4_TivOVca3xdd6-g</recordid><startdate>19990201</startdate><enddate>19990201</enddate><creator>BONILLA-FELIX, M</creator><creator>MATTI VEHASKARI, V</creator><creator>HAMM, L. 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| subjects | Algorithms Animals Animals, Newborn Arginine Vasopressin - pharmacology Biological and medical sciences Biological Transport, Active Body Water - metabolism Cyclic AMP - pharmacology Cyclooxygenase Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Indomethacin - pharmacology Kidney Concentrating Ability Kidney Tubules, Collecting - metabolism Perfusion Prostaglandins - biosynthesis Rabbits Renal Agents - pharmacology Vertebrates: urinary system |
| title | Water transport in the immature rabbit collecting duct |
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