Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells

Bufalin, a component of the Chinese medicine chan'su, induces apoptosis in various lines of human tumor cells, such as leukemia HL60 and U937 cells, by altering the expression of apoptosis-related genes, for example, bcl-2 and c-myc. In this study, we characterized a gene that is involved in bu...

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Veröffentlicht in:	Oncogene 1999-04, Vol.18 (15), p.2413-2421
Hauptverfasser:	KAWAZOE, N, WATABE, M, MASUDA, Y, NAKAJO, S, NAKAYA, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antisense RNA Apoptosis Apoptosis - drug effects Apoptosis - physiology Bcl-2 protein Biological and medical sciences Bufanolides - pharmacology c-Myc protein Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cloning, Molecular Differential display DNA fragmentation Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Neoplastic - drug effects GTP-Binding Proteins - metabolism Guanine Nucleotide Exchange Factors Humans JNK Mitogen-Activated Protein Kinases Leukemia Leukemia - drug therapy Leukemia - genetics Leukemia - metabolism Mitogen-Activated Protein Kinases Molecular and cellular biology mRNA Myc protein Nucleotide sequence p21-activated kinase p21-Activated Kinases Protein-Serine-Threonine Kinases - metabolism Proteins - genetics Proteins - metabolism rac GTP-Binding Proteins Rac1 protein RNA, Antisense - metabolism RNA, Antisense - pharmacology Signal Transduction T-Lymphoma Invasion and Metastasis-inducing Protein 1 Tiam1 protein Transcription factors Tumor cells Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism
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