Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

Summary Background Children with Down's syndrome have a greatly increased risk of acute megakaryoblastic and acute lymphoblastic leukaemias. Acute megakaryoblastic leukaemia in Down's syndrome is characterised by a somatic mutation in GATA1 . Constitutive activation of the JAK/STAT (Janus...

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Veröffentlicht in:	The Lancet (British edition) 2008-10, Vol.372 (9648), p.1484-1492
Hauptverfasser:	Bercovich, Dani, PhD, Ganmore, Ithamar, BMedSc, Scott, Linda M, PhD, Wainreb, Gilad, MSc, Birger, Yehudit, PhD, Elimelech, Arava, MSc, Shochat, Chen, MSc, Cazzaniga, Giovanni, PhD, Biondi, Andrea, MD, Basso, Giuseppe, Prof, Cario, Gunnar, MD, Schrappe, Martin, Prof, Stanulla, Martin, Prof, Strehl, Sabine, PhD, Haas, Oskar A, Prof, Mann, Georg, MD, Binder, Vera, MD, Borkhardt, Arndt, Prof, Kempski, Helena, PhD, Trka, Jan, Prof, Bielorei, Bella, MD, Avigad, Smadar, PhD, Stark, Batia, Prof, Smith, Owen, Prof, Dastugue, Nicole, PhD, Bourquin, Jean-Pierre, MD, Tal, Nir Ben, Prof, Green, Anthony R, Prof, Izraeli, Shai, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone marrow Cells Cells, Cultured Child Child, Preschool Clinical trials Down syndrome Down Syndrome - complications Down Syndrome - genetics Female GATA1 Transcription Factor - genetics Genes Genetics Genotype Humans Internal Medicine Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - genetics Leukemia Male Mice Mice, Inbred C57BL Mutation Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Proteins Studies
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