Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction
Event-related potentials (ERPs) were recorded from 15 schizophrenic patients and 17 normal controls in an auditory oddball paradigm in order to investigate the effects of stimulus probability and interstimulus interval (ISI) on deficits in mismatch negativity (MMN) generation in schizophrenia. MMN a...
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| Veröffentlicht in: | Schizophrenia research 1999-05, Vol.37 (1), p.65-79 |
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| creator | Shelley, Anne-Marie Silipo, Gail Javitt, Daniel C. |
| description | Event-related potentials (ERPs) were recorded from 15 schizophrenic patients and 17 normal controls in an auditory oddball paradigm in order to investigate the effects of stimulus probability and interstimulus interval (ISI) on deficits in mismatch negativity (MMN) generation in schizophrenia. MMN amplitude was reduced for schizophrenics overall, with the degree of deficit increasing as deviant probability decreased. In contrast, schizophrenic subjects were no more affected by alterations in ISI than controls. The experimental design also permitted evaluation of N1 generation as a function of ISI in schizophrenia. Schizophrenic subjects showed decreased N1 amplitude across conditions, with the degree of deficit increasing with increasing ISI. For both MMN and N1, therefore, the degree of deficit increased with increasing component amplitude in normals, implying that the deficit in ERP generation in schizophrenia may reflect a decrease in maximal current flow through underlying neuronal ensembles. The observed pattern of dysfunction is consistent both with observations of impaired precision of processing in schizophrenia, and with predictions of the PCP/NMDA model. |
| doi_str_mv | 10.1016/S0920-9964(98)00138-8 |
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MMN amplitude was reduced for schizophrenics overall, with the degree of deficit increasing as deviant probability decreased. In contrast, schizophrenic subjects were no more affected by alterations in ISI than controls. The experimental design also permitted evaluation of N1 generation as a function of ISI in schizophrenia. Schizophrenic subjects showed decreased N1 amplitude across conditions, with the degree of deficit increasing with increasing ISI. For both MMN and N1, therefore, the degree of deficit increased with increasing component amplitude in normals, implying that the deficit in ERP generation in schizophrenia may reflect a decrease in maximal current flow through underlying neuronal ensembles. 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Psychiatry ; Psychoses ; Reaction Time - physiology ; Schizophrenia ; Schizophrenia - physiopathology ; Working memory</subject><ispartof>Schizophrenia research, 1999-05, Vol.37 (1), p.65-79</ispartof><rights>1999 Elsevier Science B.V.</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-4bb2f4332a8a815d38d75b97b0ae990250cb9c05bac657c5131451fd7455681d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0920-9964(98)00138-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1771455$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10227109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shelley, Anne-Marie</creatorcontrib><creatorcontrib>Silipo, Gail</creatorcontrib><creatorcontrib>Javitt, Daniel C.</creatorcontrib><title>Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Event-related potentials (ERPs) were recorded from 15 schizophrenic patients and 17 normal controls in an auditory oddball paradigm in order to investigate the effects of stimulus probability and interstimulus interval (ISI) on deficits in mismatch negativity (MMN) generation in schizophrenia. MMN amplitude was reduced for schizophrenics overall, with the degree of deficit increasing as deviant probability decreased. In contrast, schizophrenic subjects were no more affected by alterations in ISI than controls. The experimental design also permitted evaluation of N1 generation as a function of ISI in schizophrenia. Schizophrenic subjects showed decreased N1 amplitude across conditions, with the degree of deficit increasing with increasing ISI. For both MMN and N1, therefore, the degree of deficit increased with increasing component amplitude in normals, implying that the deficit in ERP generation in schizophrenia may reflect a decrease in maximal current flow through underlying neuronal ensembles. The observed pattern of dysfunction is consistent both with observations of impaired precision of processing in schizophrenia, and with predictions of the PCP/NMDA model.</description><subject>Acoustic Stimulation</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Auditory</subject><subject>Biological and medical sciences</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Electroencephalography</subject><subject>Encoding</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Mismatch negativity (MMN)</subject><subject>Perception</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reaction Time - physiology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - physiopathology</subject><subject>Working memory</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkduK1TAUhoMoznb0EZRciOhFNWmbpvFGZBwPMKB4uA5pumoztEnNSge2z-LDmt29Ue-8Cqx868D_EfKQs-ec8ebFF6ZKVijV1E9V-4wxXrVFe4vsuJBVUQqmbpPdH-SM3EO8ZpkSTN4lZ5yVpeRM7civN2523uEIPY2AS_DobsADIg0Dvfz8CanzFO3ofoZljOCdpbh212AT0hSoHY3_Dhtk1t6lEPcUk5vXySQXPF1MNDMkiPiSunmZnN3qSIcQaRohRAfbKhtiyp8T7fc4rN4eqPvkzmAmhAen95x8e3v59eJ9cfXx3YeL11eFrRRLRd115VBXVWla03LRV20vRadkxwwoxXIYtlOWic7YRkgreMVrwYde1kI0Le-rc_LkOHeJ4ccKmPTs0MI0GQ9hRd0oWbZKNBkUR9DGgBhh0Et0s4l7zZk-aNGbFn3IXKtWb1p0m_senRas3Qz9P11HDxl4fAIM5hCGaLx1-JeTMp8sMvbqiEFO48ZB1GgdeAu9i9mI7oP7zyW_AURgrbM</recordid><startdate>19990504</startdate><enddate>19990504</enddate><creator>Shelley, Anne-Marie</creator><creator>Silipo, Gail</creator><creator>Javitt, Daniel C.</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990504</creationdate><title>Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction</title><author>Shelley, Anne-Marie ; Silipo, Gail ; Javitt, Daniel C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-4bb2f4332a8a815d38d75b97b0ae990250cb9c05bac657c5131451fd7455681d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Acoustic Stimulation</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Auditory</topic><topic>Biological and medical sciences</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Electroencephalography</topic><topic>Encoding</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Mismatch negativity (MMN)</topic><topic>Perception</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reaction Time - physiology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - physiopathology</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shelley, Anne-Marie</creatorcontrib><creatorcontrib>Silipo, Gail</creatorcontrib><creatorcontrib>Javitt, Daniel C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shelley, Anne-Marie</au><au>Silipo, Gail</au><au>Javitt, Daniel C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>1999-05-04</date><risdate>1999</risdate><volume>37</volume><issue>1</issue><spage>65</spage><epage>79</epage><pages>65-79</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Event-related potentials (ERPs) were recorded from 15 schizophrenic patients and 17 normal controls in an auditory oddball paradigm in order to investigate the effects of stimulus probability and interstimulus interval (ISI) on deficits in mismatch negativity (MMN) generation in schizophrenia. MMN amplitude was reduced for schizophrenics overall, with the degree of deficit increasing as deviant probability decreased. In contrast, schizophrenic subjects were no more affected by alterations in ISI than controls. The experimental design also permitted evaluation of N1 generation as a function of ISI in schizophrenia. Schizophrenic subjects showed decreased N1 amplitude across conditions, with the degree of deficit increasing with increasing ISI. For both MMN and N1, therefore, the degree of deficit increased with increasing component amplitude in normals, implying that the deficit in ERP generation in schizophrenia may reflect a decrease in maximal current flow through underlying neuronal ensembles. The observed pattern of dysfunction is consistent both with observations of impaired precision of processing in schizophrenia, and with predictions of the PCP/NMDA model.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>10227109</pmid><doi>10.1016/S0920-9964(98)00138-8</doi><tpages>15</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Acoustic Stimulation Adult Adult and adolescent clinical studies Auditory Biological and medical sciences Brain - physiopathology Brain Mapping Electroencephalography Encoding Evoked Potentials - physiology Female Humans Male Medical sciences Memory - physiology Mismatch negativity (MMN) Perception Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reaction Time - physiology Schizophrenia Schizophrenia - physiopathology Working memory |
| title | Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction |
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