Immortalization of human melanocytes does not alter the de novo properties of nitric oxide to induce cell detachment from extracellular matrix components via cGMP

Nitric oxide (NO) is an important mediator in many (patho)physiological processes including inflammation and skin cancer. A key transducer in NO signaling is the soluble guanylyl cyclase (sGC) that catalyzes the formation of guanosine 3′,5′-cyclic monophosphate (cGMP). The basic mechanism of NO-cGMP...

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Veröffentlicht in:	In vitro cellular & developmental biology. Animal 2008-09, Vol.44 (8-9), p.385-395
Hauptverfasser:	Ivanova, Krassimira, Lambers, Britta, van den Wijngaard, Rene, Le Poole, I. Caroline, Grigorieva, Olga, Gerzer, Rupert, Das, Pranab K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Apoptosis ATP binding cassette transporters Biomedical and Life Sciences Cell Adhesion Cell Biology Cell Culture Cell lines cGMP Cyclic GMP - metabolism Detachment Developmental Biology Extracellular Matrix - metabolism Guanylate Cyclase - metabolism Human papillomavirus 16 Human papillomavirus 16 - metabolism Humans Immortalized melanocytes Life Sciences Melanin Melanocytes Melanocytes - cytology Melanocytes - metabolism Melanoma Nitric oxide Nitric Oxide - metabolism Nitric Oxide - pharmacology Oncogene Proteins, Viral - metabolism Oxidative stress Oxides Papillomavirus E7 Proteins Protein isoforms Receptors, Cytoplasmic and Nuclear - metabolism Reverse transcriptase polymerase chain reaction Signal Transduction Soluble Guanylyl Cyclase Stem Cells Transfection
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