HIV rebounds from latently infected cells, rather than from continuing low-level replication

Rapid rebound of plasma viremia in patients after interruption of long-term combination antiretroviral therapy (cART) suggests persistence of low-level replicating cells or rapid reactivation of latently infected cells. To further characterize rebounding virus, we performed extensive longitudinal cl...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2008-10, Vol.105 (43), p.16725-16730
Hauptverfasser:	Joos, Beda, Fischer, Marek, Kuster, Herbert, Pillai, Satish K, Wong, Joseph K, Böni, Jürg, Hirschel, Bernard, Weber, Rainer, Trkola, Alexandra, Günthard, Huldrych F
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiretroviral drugs Antiretrovirals Biological Sciences Carts Cells Cells, Cultured Drug therapy Evolution Evolutionary genetics Genetic Variation HIV HIV - genetics HIV - physiology HIV 1 HIV Infections - drug therapy HIV Infections - virology Human immunodeficiency virus Humans Infections Molecular Sequence Data Phylogeny Pretreatment Receptors, CXCR4 Receptors, HIV Viremia Virus Activation Virus Latency - drug effects Virus Replication - drug effects Viruses
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