Regulatory Effect of Hydrogen Sulfide on Vascular Collagen Content in Spontaneously Hypertensive Rats

The present study aimed to examine the regulatory effect of hydrogen sulfide (H 2 S) on vascular collagen remodeling in hypertensive rats. After 5 weeks of H 2 S donor treatment, tail blood pressure, the endogenous H 2 S production rate, levels of hydroxyproline and collagen type I, collagen type I...

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Veröffentlicht in:	Hypertension research 2008-08, Vol.31 (8), p.1619-1630
Hauptverfasser:	Zhao, Xia, Zhang, Li-ke, Zhang, Chun-yu, Zeng, Xiang-jun, Yan, Hui, Jin, Hong-fang, Tang, Chao-shu, Du, Jun-bao
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Aorta, Thoracic - cytology Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Blood Pressure - drug effects Blood Pressure - physiology Cell Division - drug effects Cell Division - physiology Collagen Type I - metabolism Geriatrics/Gerontology Health Promotion and Disease Prevention Hydrogen Sulfide - metabolism Hydrogen Sulfide - pharmacology Hydroxyproline - pharmacokinetics Hydroxyproline - secretion Hypertension - metabolism Internal Medicine Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Medicine Medicine & Public Health Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Obstetrics/Perinatology/Midwifery original-article Proline - pharmacokinetics Public Health Rats Rats, Inbred SHR Rats, Inbred WKY Receptor, Angiotensin, Type 1 - metabolism Thymidine - pharmacokinetics Tritium Vasoconstrictor Agents - pharmacology
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