Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

T cell activation is mediated by microclusters (MCs) containing T cell receptors (TCRs), kinases, and adaptors. Although TCR MCs translocate to form a central supramolecular activation cluster (cSMAC) of the immunological synapse at the interface of a T cell and an antigen-presenting cell, the role...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2008-10, Vol.29 (4), p.589-601
Hauptverfasser:	Yokosuka, Tadashi, Kobayashi, Wakana, Sakata-Sogawa, Kumiko, Takamatsu, Masako, Hashimoto-Tane, Akiko, Dustin, Michael L., Tokunaga, Makio, Saito, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD28 Antigens - metabolism Cells, Cultured Dendritic Cells - immunology Mice Mice, Knockout Mice, Transgenic MOLIMMUNO Protein Kinase C - metabolism Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism
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