Probing the Lower Size Limit for Protein-Like Fold Stability: Ten-Residue Microproteins With Specific, Rigid Structures in Water

Mutational optimization of two long-range interactions first observed in Ac-WINGKWT-NH2, (a) bifurcated H-bonding involving the threonine amide HN and side chain OH and the N-terminal acetyl carbonyl and (b) an H-bond between the entgegen-HN of the C-terminal amide and the indole ring of Trp6 that s...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-11, Vol.130 (44), p.14675-14683
Hauptverfasser:	Kier, Brandon L, Andersen, Niels H
Format:	Artikel
Sprache:	eng
Schlagworte:	Deuterium Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Kinetics Models, Molecular Nuclear Magnetic Resonance, Biomolecular - methods Oligopeptides - chemistry Protein Folding Structure-Activity Relationship Temperature Water - chemistry
Online-Zugang:	Volltext
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